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UBE2D1


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Symbol:UBE2D1
Name(s):ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17373700 Observational study of gene-disease association. (HuGE Navigator)
15139022 comparison of the regional distribution of SFT/UbcH5A and DMT1 mRNA in the adult brain
12480712 UbcH5A is up-regulated in the liver of iron-overloaded patients with hereditary hemochromatosis, but in vitro studies failed to show regulation in response to iron loading or chelation. Earlier in vivo mRNA expression data for SFT might be UbcH5A.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHomo sapiens chromosome 11, reference assembly.-The cIAP-2 promoter interacts with Ubc5.-Pubmed
HPRDSeven in absentia homolog 1ubiquitin-conjugating enzyme E2D 1--Pubmed
HPRDSeven in absentia homolog 1ubiquitin-conjugating enzyme E2D 1--Pubmed
HPRDUbiquitin conjugating enzyme E2D1ubiquitin protein ligase E3A isoform 2--Pubmed
HPRDUbiquitin conjugating enzyme E2D1STIP1 homology and U-Box containing protein 1--Pubmed
HPRDUbiquitin conjugating enzyme E2D1deltex 3-like--Pubmed
HPRDubiquitin-conjugating enzyme E2D 1Ubiquitin protein ligase E3A--Pubmed
HPRDubiquitin-conjugating enzyme E2D 1STIP1 homologous and U box containing protein 1--Pubmed
BINDubiquitin-conjugating enzyme E2D 1ring finger protein 11RNF11 interacts with UbcH5a.-Pubmed
HPRDubiquitin-conjugating enzyme E2D 1U-box domain containing 5 isoform a--Pubmed

Recent Publications on UBE2D1:

Pubmed Logo
Effect of Arabidopsis COP10 ubiquitin E2 enhancement activity across E2 families and functional conservation among its canonical homologues.
Arabidopsis thaliana COP10 (constitutive photomorphogenic 10) is a UEV [Ub...
17th March, 2009
Department of Molecular, Cellular and Developmental Biology, Yale Biochem J. 2009 Mar 15;418(3):683-90.
DOI Direct Link
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
Fused Toes (FTS) is a member of a small group of inactive variant E2...
11th March, 2009
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. Mol Biol Cell. 2008 Dec;19(12):5059-71. Epub 2008 Sep 17.
DOI Direct Link
The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.
Patients with the systemic autoimmune diseases Sjogrens's syndrome and...
16th January, 2009
Rheumatology Unit, Department of Medicine, CMM L8:04, Karolinska Exp Cell Res. 2008 Dec 10;314(20):3605-13. Epub 2008 Sep 25.
DOI Direct Link
Structure of a Shigella effector reveals a new class of ubiquitin ligases.
Bacterial pathogens have evolved effector proteins with ubiquitin E3...
1st January, 2009
National Institute of Biological Sciences, 7# Science Park Road, Nat Struct Mol Biol. 2008 Dec;15(12):1302-8. Epub 2008 Nov 9.
DOI Direct Link
Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p.
The Saccharomyces cerevisiae (Sc) PTS1 import receptor Pex5p is modified...
11th September, 2008
Department of Medical Biochemistry, Academic Medical Center, Meibergdreef Biochem Biophys Res Commun. 2008 Oct 3;374(4):620-4. Epub 2008 Jul 21.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598080 Diagnostic assay for source of inflammation
7524642 Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
7378248 In vivo production of cyclic peptides for inhibiting protein-protein interaction
7252952 In vivo production of cyclic peptides for inhibiting protein--protein interaction
7132234 Methods and compositions for the identification of anti-poxvirus agents

View more patents.

UBE2D1 results (if any) from reagent suppliers

Google CSE Logo
UBE2D1 Antibody (C-term)
#AP2112b) in, left-to-right, wild-type T3 cells (mouse mouse fibroblast cell line), wild-type T3 cells plus recombinant mouse UBE2D1(120 ng), and Hela cells
...
http://www.abgent.com/products/catalog_no/AP2112b_UBE2D1_Ant...

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UBE Antibody / UBE Antibodies
UBE2D1 (C-22) 抗体, sc-130283, rabbit IgG, N/A, WB, IP, F, IHC(P), ELISA, human .... UBE2D1 shRNA Plasmid (m): sc-41680-SH. UBE2D1 shRNA (m) ...
http://www.scbt.com/ja/table-ube.html...

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Protein Modification - Ubiquitination Antibody
AP2112b, UBE2D1 Antibody (C-term), WB, IHC, E, H, M. AT4431aNEW, UBE2D1 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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UBE2D1 (C-22) Antibody sc-130283
UBE2D1 (C-22) Anticorpo sc-130283 UBE2D1 (C-22) Antibody sc-130283.
http://www.scbt.com/it/datasheet-130283-ube2d1-c-22-antibody...

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All Ubiquitin E2 Enzymes | Abcam
UBE2D1 protein (Human). Conjugation, SDS-PAGE. ab81579 · UBE2D1 protein (Human). Conjugation, SDS-PAGE ... UBE2D1 protein (Tagged). Conjugation, SDS-PAGE ...
http://www.abcam.com/index.html?c=1039...

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UBE2D1 (C-22) Antibody sc-130283
UBE2D1 shRNA (h) Lentiviral Particles, sc-41679-V, 200 µl ... UBE2D1 (C-22): sc- 130283. Western blot analysis of UBE2D1 expression in Jurkat whole cell ...
http://www.scbt.com/ko/datasheet-130283-ube2d1-c-22-antibody...

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Ctnnb1 antibody, Beta-catenin Antibody, Rabbit Polyclonal Antibody
Ptm: Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1A, APC and TBL1X (Probable). Its ubiquitination leads to its ...
http://www.genwaybio.com/product_info.php?products_id=20068...

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