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UBE2D3


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Symbol:UBE2D3
Name(s):ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:E2(17)KB3, MGC43926, MGC5416, UBC4/5, UBCH5C
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17420285 Knocking down UBE2D3 by RNA interference leads to blockage oof retinoic acid induced chclin D1 degradation and cell cycle arrest.
15280377 UbcH5B/C are E2s for Mdm2, which contribute to the maintenance of low levels of p53 and Mdm2 in unstressed cells; inhibition of p53 ubiquitination and degradation by targeting UbcH5B/C is not sufficient to up-regulate p53 transcriptional activity.
12215439 Transducin beta-gamma is a substrate of UbcH5c (UBE2D3), UbcH7 (UBE2L3) and the ubiquitin-proteasome pathway only following the dissociation of transducin alpha from beta-gamma. Transducin beta-gamma is protected from ubiquitylation by phosducin.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBRCA1 associated RING domain 1ubiquitin-conjugating enzyme E2D 3 isoform 1--Pubmed
HPRDBRCA1 associated RING domain 1ubiquitin-conjugating enzyme E2D 3 isoform 1--Pubmed
HPRDbreast cancer 1, early onset isoform 1ubiquitin-conjugating enzyme E2D 3 isoform 1--Pubmed
HPRDbreast cancer 1, early onset isoform 1ubiquitin-conjugating enzyme E2D 3 isoform 1--Pubmed
HPRDneural precursor cell expressed, developmentally down-regulated 4 isoform 2ubiquitin-conjugating enzyme E2D 3 isoform 1--Pubmed
HPRDneural precursor cell expressed, developmentally down-regulated 4 isoform 2ubiquitin-conjugating enzyme E2D 3 isoform 1--Pubmed
HPRDUbiquitin conjugating enzyme E2D 3ubiquitin protein ligase E3A isoform 2--Pubmed
BIND-ring finger protein 11RNF11 interacts with UbcH5c.-Pubmed
HPRDUbiquitin conjugating enzyme E2D 3deltex 3-like--Pubmed
HPRDubiquitin-conjugating enzyme E2D 3 isoform 1Ubiquitin protein ligase E3A--Pubmed

Recent Publications on UBE2D3:

Pubmed Logo
Origin and evolution of ubiquitin-conjugating enzymes from Guillardia theta nucleomorph to hominoid.
The origin of eukaryotic ubiquitin-conjugating enzymes (E2s) can be traced...
9th October, 2009
State Key Laboratory of Reproductive Biology, Institute of Zoology, Gene. 2009 Nov 15;447(2):72-85. Epub 2009 Aug 5.
DOI Direct Link
Direct activation of protein kinases by unanchored polyubiquitin chains.
TRAF6 is a ubiquitin ligase that is essential for the activation of...
2nd October, 2009
Department of Molecular Biology, University of Texas, Southwestern Medical Nature. 2009 Sep 3;461(7260):114-9. Epub 2009 Aug 12.
DOI Direct Link
PCNA is ubiquitinated by RNF8.
The ubiquitination of PCNA is an essential event in the operation of the...
12th February, 2009
Department of Biochemistry and Molecular Biology, New York Medical Cell Cycle. 2008 Nov 1;7(21):3399-404.
A ubiquitin-conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus.
The Jun N-terminal kinase kinase kinase MLK2 is required for the formation...
9th August, 2008
Department of Medical Biology, Cancer Research Centre, Laval University, Differentiation. 2008 Apr;76(4):431-41. Epub 2007 Nov 15.
DOI Direct Link
Physical and functional interactions between ZIP kinase and UbcH5.
Zipper-interacting protein kinase (ZIPK) is a widely expressed...
25th July, 2008
Department of Immunology, Graduate School of Pharmaceutical Sciences, Biochem Biophys Res Commun. 2008 Aug 8;372(4):708-12. Epub 2008 Jun 2.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6919184 Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
6979551 Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
7108972 Proteins, polynucleotides encoding them and methods of using the same
7132234 Methods and compositions for the identification of anti-poxvirus agents

View more patents.

UBE2D3 results (if any) from reagent suppliers

Google CSE Logo
UBE2D (C-15) Antibody sc-15000
Western blot analysis of UBE2D3 expression in non-transfected: sc-117752 (A) and mouse UBE2D3 transfected: sc-124412 (B) 293T whole cell lysates. Download ...
http://www.scbt.com/datasheet-15000-UBE2D-c-15-antibody.html...

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All Ubiquitin E2 Enzymes | Abcam
UBE2D3 protein (Human). Conjugation, SDS-PAGE. ab81571 · UBE2D3 protein (Tagged) . Conjugation, SDS-PAGE. ab59314 · UBE2D3 protein (Tagged). SDS-PAGE ...
http://www.abcam.com/index.html?c=1039...

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UBE Antibody / UBE Antibodies
UBE2D3 (Y-25) 抗体, sc-100618, mouse IgG1, FL (h), WB, IP, ELISA, human .... UBE2D3 shRNA Plasmid (h): sc-41681-SH. UBE2D3 shRNA (h) ...
http://www.scbt.com/ja/table-ube.html...

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Protein Modification - Ubiquitination Antibody
AT4432aNEW, UBE2D2 monoclonal antibody (M02), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H . AT4433aNEW, UBE2D3 monoclonal antibody (M01), ELISA,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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UBE2D3 siRNA (h) sc-41681
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: UBE2D3 (h)-PR: sc-41681-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-41681-UBE2D3-sirna-h.html...

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Cell Biology: primary antibodies, proteins, peptides, kits | Abcam
... UBE2D1 proteins and peptides (5) · UBE2D2 antibodies (2) · UBE2D2 proteins and peptides (3) · UBE2D3 antibodies (2) · UBE2D3 proteins and peptides (3) ...
http://www.abcam.com/index.html?cl=246&pageconfig=productmap...

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UBE2D3 (m): 293T Lysate sc-124412
UBE2D3 (Y-25): sc-100618. Western blot analysis of UBE2D3 expression in non- transfected: sc-117752 (A) and mouse UBE2D3 transfected: sc-124412 (B) 293T ...
http://www.scbt.com/ko/datasheet-124412-ube2d3-m-293t-lysate...

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