Friday November 27 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

UBE2I


Suggest Content
Advertise Here
Gene DB Home
Symbol:UBE2I
Name(s):ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:C358B7.1, P18, UBC9
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17956732 RSUME increases noncovalent binding of SUMO-1 to Ubc9 and enhances Ubc9 thioester formation and SUMO polymerization.
17671234 Ubc9 is an important C/EBPalphap30 target through which C/EBPalphap30 enhances the sumoylation of C/EBPalphap42 to inhibit granulocytic differentiation.
17698038 RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation
17037517 the nucleocapsid protein of severe acute respiratory syndrome coronavirus is sumoylated by interaction with Ubc9
14517060 interacts with Mason-Pfizer monkey virus Gag in cells. This strengthens the hypothesis that Gag proteins transiently associate with the nuclear compartment during viral replication, and suggest that hUbc9 plays a role in this process
16998888 This is the first report demonstrating the interaction of hUbc9 with a structural protein of plus-strand RNA viruses, indicating a new drug target for SARS-CoV.
17105732 Ubc9 has a role as a transcriptional MR coactivator, beyond the known SUMO E2-conjugating enzyme
14765993 ubiquitin-conjugating enzyme E2I functions as a novel COUP-TFI corepressor, the function of which is distinct from its SUMO-1 conjugating enzyme activity.
16566921 Results suggest that Ubc9 might regulate bcl-2 expression through the ER signaling pathway, which ultimately contributes to the alterations of drug responsiveness and tumor growth.
15246872 Ubc9 has a role in inhibition of diadenosine triphosphate hydrolase activity of the putative tumor suppressor protein Fhit

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDApex nucleaseubiquitin-conjugating enzyme E2I--Pubmed
HPRDFas receptorubiquitin-conjugating enzyme E2I--Pubmed
HPRDtumor necrosis factor receptor superfamily, member 6 isoform 1 precursorUbiquitin conjugating enzyme E2I--Pubmed
HPRDandrogen receptor isoform 1ubiquitin-conjugating enzyme E2I--Pubmed
BINDHuman myeloid-specific C/EBP-epsilon transcription factor gene, and translated productsubiquitin-conjugating enzyme E2IC/EBP-epsilon interacts with UBE2I.-Pubmed
HPRDCHD3ubiquitin-conjugating enzyme E2I--Pubmed
BINDHomo sapiens CHD3 mRNA, and translated productsubiquitin-conjugating enzyme E2IUbc9 interacts with CHD3.-Pubmed
HPRDHomo sapiens zinc-finger helicase mRNA, complete cds.Ubiquitin conjugating enzyme E2I--Pubmed
HPRDchromodomain helicase DNA binding protein 3 isoform 3Ubiquitin conjugating enzyme E2I--Pubmed
HPRDactivating transcription factor 2Ubiquitin conjugating enzyme E2I--Pubmed

Recent Publications on UBE2I:

Pubmed Logo
Origin and evolution of ubiquitin-conjugating enzymes from Guillardia theta nucleomorph to hominoid.
The origin of eukaryotic ubiquitin-conjugating enzymes (E2s) can be traced...
9th October, 2009
State Key Laboratory of Reproductive Biology, Institute of Zoology, Gene. 2009 Nov 15;447(2):72-85. Epub 2009 Aug 5.
DOI Direct Link
Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study.
Ubiquitin-conjugating enzyme E2I (Ubc9) ligates small ubiquitin-related...
22nd September, 2009
Division of Brain Diseases, Center for Biomedical Sciences, National Neurosci Lett. 2009 Nov 20;465(3):272-5. Epub 2009 Sep 17.
DOI Direct Link
UBE2I (UBC9), a SUMO-conjugating enzyme, localizes to nuclear speckles and stimulates transcription in mouse oocytes.
Sumoylation is a posttranslational modification in which SUMO (small...
17th December, 2008
Department of Biology, University of Pennsylvania, Philadelphia, Biol Reprod. 2008 Nov;79(5):906-13. Epub 2008 Aug 13.
DOI Direct Link
Developmental control of sumoylation pathway proteins in mouse male germ cells.
Protein sumoylation regulates a variety of nuclear functions and has been...
9th September, 2008
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. Dev Biol. 2008 Sep 1;321(1):227-37. Epub 2008 Jun 21.
DOI Direct Link
Sensitization against anticancer drugs by transfection with UBE2I variant gene into ras-NIH3H3 mouse fibroblasts.
We previously performed SEREX (serological identification of antigens by...
6th December, 2007
Departments of Frontier Surgery, Graduate School of Medicine, Chiba Anticancer Res. 2007 Sep-Oct;27(5A):3227-33.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6936417 Gene expression in bladder tumors
6706867 DNA array sequence selection
5994076 Methods of assaying differential expression

UBE2I results (if any) from reagent suppliers

Google CSE Logo
UBE2I / UBC9 antibody (ab21193) | Abcam
Goat polyclonal to UBE2I / UBC9. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived ...
http://www.abcam.com/UBE2I-UBC9-antibody-ab21193.html...

Thumbshot
UBE2I antibody, UBE2I (ubiquitin-conjugating enzyme E2I (UBC9 ...
Buy quality rabbit UBE2I antibody (interacts with human mouse rat dog zebra fish ), anti-UBE2I, UBE2I (ubiquitin-conjugating enzyme E2I (UBC9 homolog. ...
http://www.genwaybio.com/product_info.php?products_id=44758...

Thumbshot
UBE2I / UBC9 antibody [EP2938Y] (ab75854) | Abcam
Rabbit monoclonal [EP2938Y] to UBE2I / UBC9. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or ...
http://www.abcam.com/UBE2I-UBC9-antibody-EP2938Y-ab75854.htm...

Thumbshot
Protein Modification - Sumoylation Antibody
AP1064b, UBC9 (UBE2I) Antibody (C-term), IHC, E, H. AP1064a, UBC9 (UBE2I) Antibody (N-term), WB, IHC, E, H. AM1261a, UBC9 Antibody, WB, E, H, M ...
http://www.abgent.com/products/category/protein_modification...

Thumbshot
UBE2I / UBC9 antibodies: Cell Biology > Proteolysis / Ubiquitin ...
UBE2I / UBC9 antibodies. ... UBE2I / UBC9 antibody. IHC-P, WB, ELISA, ICC/IF ... UBE2I / UBC9 antibody [EP2938Y]. Flow Cyt, ICC, IP, WB, IHC-P ...
http://www.abcam.com/index.html?t=14163&pt=1&c=1039&ei=&mu=r...

Thumbshot
SUMO1 antibody, Anti-SUMO (Yeast) Antibody, Rabbit N/A Antibody
Subunit: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. ... Anti-SUMO ( Yeast) interacts with UBE2I (ubiquitin-conjugating enzyme E2I (UBC9 homolog. ...
http://www.genwaybio.com/product_info.php?products_id=292212...

Thumbshot
UBE2I / UBC9 protein (ab3803) | Abcam
UBE2I / UBC9 protein. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for
...
http://www.abcam.com/UBE2I-UBC9-protein-ab3803.html...

Thumbshot

Search Bioportfolio and other Life Science Sites for UBE2I, or search for UBE2I on BioPortfolio's antibody search engine.
This page has been viewed 170 times
Recent Search Terms used to find this page:
ubc9 immune | ubc9 immune | ubiquitin conjugating enzyme E2I | Ubc9 drug target | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.