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UBE2L3


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Symbol:UBE2L3
Name(s):ubiquitin-conjugating enzyme E2L 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:E2-F1, L-UBC, UBCH7, UbcM4
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16703398 UBE2L3, the c-myc-regulated gene is involved in genotype-C-HBV-related HCC, suggesting that c-myc is related to the hepatocarcinogenic activity of genotype-C HBV.
12215439 Transducin beta-gamma is a substrate of UbcH5c (UBE2D3), UbcH7 (UBE2L3) and the ubiquitin-proteasome pathway only following the dissociation of transducin alpha from beta-gamma. Transducin beta-gamma is protected from ubiquitylation by phosducin.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBRCA1 associated ring domain 1ubiquitin-conjugating enzyme E2L 3 isoform 1--Pubmed
HPRDBRCA1 associated RING domain 1Ubiquitin conjugating enzyme E2L3--Pubmed
HPRDBRCA1ubiquitin-conjugating enzyme E2L 3 isoform 1--Pubmed
HPRDbreast cancer 1, early onset isoform 1Ubiquitin conjugating enzyme E2L3--Pubmed
HPRDCBLubiquitin-conjugating enzyme E2L 3 isoform 1--Pubmed
BINDCas-Br-M ecotropic retroviral transforming sequence-c-Cbl interacts with an unspecified isoform of UbcH7. This interaction was modeled on a demonstrated interaction between c-Cbl from an unspecified species and human UbcH7.-Pubmed
HPRDSMAD4ubiquitin-conjugating enzyme E2L 3 isoform 1--Pubmed
HPRDmothers against decapentaplegic homolog 4Ubiquitin conjugating enzyme E2L3--Pubmed
HPRDneural precursor cell expressed, developmentally down-regulated 4 isoform 2ubiquitin-conjugating enzyme E2L 3 isoform 1--Pubmed
HPRDneural precursor cell expressed, developmentally down-regulated 4 isoform 2ubiquitin-conjugating enzyme E2L 3 isoform 1--Pubmed

Recent Publications on UBE2L3:

Pubmed Logo
Origin and evolution of ubiquitin-conjugating enzymes from Guillardia theta nucleomorph to hominoid.
The origin of eukaryotic ubiquitin-conjugating enzymes (E2s) can be traced...
9th October, 2009
State Key Laboratory of Reproductive Biology, Institute of Zoology, Gene. 2009 Nov 15;447(2):72-85. Epub 2009 Aug 5.
DOI Direct Link
1H, 13C and 15N resonance assignments for the human E2 conjugating enzyme, UbcH7.
UbcH7 is a human E2 conjugating enzyme in the ubiquitin-dependent protein...
27th August, 2009
Department of Biochemistry, The University of Western Ontario, London, ON, Biomol NMR Assign. 2008 Jun;2(1):21-3. Epub 2007 Dec 28.
DOI Direct Link
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
In eukaryotic cells the stability and function of many proteins are...
25th June, 2009
Department of Medicine, Cambridge Institute for Medical Research, Genome Res. 2009 Oct;19(10):1905-11. Epub 2009 Jun 23.
DOI Direct Link
Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7.
Timely degradation of regulatory proteins by the ubiquitin proteolytic...
28th March, 2009
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts Mol Biol Cell. 2009 Jan;20(1):1-9. Epub 2008 Oct 22.
DOI Direct Link
E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity.
The E2 ubiquitin-conjugating enzymes UbcH7 and UbcH5B both show specific...
4th February, 2009
Department of NMR Spectroscopy, Bijvoet Center for Biomolecular Research, J Mol Biol. 2009 Jan 16;385(2):507-19. Epub 2008 Nov 1.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7601532 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
6919184 Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
6979551 Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7132234 Methods and compositions for the identification of anti-poxvirus agents

View more patents.

UBE2L3 results (if any) from reagent suppliers

Google CSE Logo
UBE2L3 Antibody #3848
Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to residues surrounding Lys145 of human
UBE2L3 ...
http://www.cellsignal.com/products/3848.html...

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Anti-UBE2L3 Polyclonal Antibody
Polyclonal Antibody against UBE2L3 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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UBE2L3 antibody, UBE2 L3 Antibody, Goat Polyclonal Antibody
Buy quality goat UBE2L3 antibody (interacts with target species: human based on sequence similarity is expected to react with: mouse nb), anti-UBE2L3, ...
http://www.genwaybio.com/product_info.php?products_id=75514...

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UBE2L3 Antibody (C-term)
Western blot analysis of anti-UBE2L3 Antibody (C-term) (Cat.#AP2117b) in K562 cell line lysates (35ug/lane). UBE2L3 (arrow) was detected using the purified
...
http://www.abgent.com/products/catalog_no/AP2117b_UBE2L3_Ant...

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WH0007332M1 Monoclonal Anti-UBE2L3 antibody produced in mouse ...
WH0007332M1 Monoclonal Anti-UBE2L3 antibody produced in mouse clone 3B7, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=WH00...

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UBE2L3 Antibody (N-term)
#AP2117a) is used in Western blot to detect UBE2L3 in HL-60 cell lysate. UBE2L3 Antibody (N-term). Formalin-fixed and paraffin-embedded human cancer tissue ...
http://www.abgent.com/products/catalog_no/AP2117a_UBE2L3_Ant...

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UBE2L3 siRNA (m) sc-61747
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: UBE2L3 (m)-PR: sc-61747-PR, 20 µl ...
http://www.scbt.com/ja/datasheet-61747-UBE2L3-sirna-m.html...

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