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UBE2N
| Symbol: | UBE2N | | Name(s): | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | MGC131857, MGC8489, UBC13, UbcH-ben | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18077395 |
the human Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage |
| 17942533 |
Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-kappaB activation. |
| 17709375 |
modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism |
| 12569095 |
An NMR-based model of the ubiquitin-bound human complex and the structural basis of lysine 63 chain catalysis. |
| 17349954 |
These data reveal a critical and unexpected role for vertebrate Ubc13 in the initiation of homologous recombination at the level of double-strand break processing. |
| 16122702 |
ISGylation of Ubc13 disrupts its ability to form thioester bond with ubiquitin |
| 15749714 |
The results in this study allowed identification of important residues of the Ubc13-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 but not other Ubc proteins. |
| 14562038 |
Ubc13-Mms2 and Lys63-polyubiquitin chains are associated with signaling cellular stress |
| 12039045 |
This paper describes the function of the mouse protein, but suggests the function of the human protein, since both human and mouse proteins are 100% identical. |
Recent Publications on UBE2N: |  |
[Maintenance of genome stability though Ubc13-dependent ubiquitination]
Chromatin modifications are an important component of the of DNA damage... | 3rd November, 2009
| Department of Radiation Genetics, Graduate School of Medicine, Kyoto
| Seikagaku. 2009 Jul;81(7):601-5.
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Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
Chromatin modifications are an important component of the of DNA damage... | 16th October, 2009
| Department of Genetics, Center for Biomedical Genetics, Erasmus Medical
| J Cell Biol. 2009 Sep 21;186(6):835-47.
DOI Direct Link |
Origin and evolution of ubiquitin-conjugating enzymes from Guillardia theta nucleomorph to hominoid.
The origin of eukaryotic ubiquitin-conjugating enzymes (E2s) can be traced... | 9th October, 2009
| State Key Laboratory of Reproductive Biology, Institute of Zoology,
| Gene. 2009 Nov 15;447(2):72-85. Epub 2009 Aug 5.
DOI Direct Link |
Direct activation of protein kinases by unanchored polyubiquitin chains.
TRAF6 is a ubiquitin ligase that is essential for the activation of... | 2nd October, 2009
| Department of Molecular Biology, University of Texas, Southwestern Medical
| Nature. 2009 Sep 3;461(7260):114-9. Epub 2009 Aug 12.
DOI Direct Link |
The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains.
Ubiquitination plays a major role in many aspects of hematopoiesis.... | 22nd September, 2009
| Central Hematology Laboratory, Nijmegen Centre for Molecular Life
| Leukemia. 2009 Aug;23(8):1480-9. Epub 2009 Apr 2.
DOI Direct Link |
→View more research publications. |
UBE2N results (if any) from reagent suppliers | 
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Anti-UBE2N Polyclonal Antibody
Polyclonal Antibody against UBE2N for use in Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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Ube2N antibody (ab25885) | Abcam
Rabbit polyclonal to Ube2N. Ube2N is a member of the E2 ubiquitin conjugating enzyme family. The modification of proteins with ubiquitin is an important ...
http://www.abcam.com/Ube2N-antibody-ab25885.html...
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UBE2N antibody, UBE2N (ubiquitin-conjugating enzyme E2N (UBC13 ...
Buy quality rabbit UBE2N antibody (interacts with human), anti-UBE2N, UBE2N ( ubiquitin-conjugating enzyme E2N (UBC13 homolog. yeast)) antibody, ...
http://www.genwaybio.com/product_info.php?products_id=42472...
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UBE2N Antibody (N-term)
Western blot analysis of anti-UBE2N Antibody (N-term) (Cat.#AP2125a) in CEM cell line lysates (35ug/lane). UBE2N(arrow) was detected using the purified Pab. ...
http://www.abgent.com/products/catalog_no/AP2125a_UBE2N_Anti...
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Ube2N antibodies: Chromatin and Nuclear Signaling > Chromatin ...
Ube2N antibodies. ... Ube2N antibody [4E11]. WB, ELISA, ICC/IF. Customer Abreviews: 1 stars (out of 5). Mouse monoclonal ...
http://www.abcam.com/index.html?t=14161&pt=1&c=566&ei=&mu=ra...
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Purified Anti-Aurora A Aurora 2-Phosphorylated Thr288 Antibody ...
The Phe 31 variant has been shown to interact with the E2 ubiquitin-conjugating enzyme, UBE2N. The Poly6187 antibody has been shown to react with ...
http://www.biolegend.com/purified-anti-aurora-a-aurora-2-pho...
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UBE2N (4E11) Antibody sc-58452
mouse monoclonal IgG1, 200µg/ml; raised against full length UBE2N of human origin; recommended for detection of UBE2N of m, r and h origin by WB, ...
http://www.scbt.com/ko/datasheet-58452-ube2n-4e11-antibody.h...
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