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UBE2V2
| Symbol: | UBE2V2 | | Name(s): | ubiquitin-conjugating enzyme E2 variant 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18284681 |
These results point to a high level of redundancy in the DNA damage tolerance pathway and suggest the existence of another hMMS2 variant (hMMSv) or complex that can compensate for its loss. |
| 17964296 |
Mms2 physical association with ubiquitin is correlated with its ability to promote Lys63-linked ubiquitin chain assembly |
| 16129784 |
Data demonstrate that divergent activities of Ubc13 rely on its pairing with either of two Uevs, Uev1A or Mms2. |
| 15749714 |
The results in this study allowed identification of important residues of the Ubc13-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 but not other Ubc proteins. |
| 14562038 |
Ubc13-Mms2 and Lys63-polyubiquitin chains are associated with signaling cellular stress |
| 15725630 |
UBE2v2 signalling through PCNA ubiquitination is not required for immunoglobulin diversification in DT40 cells. |
| 15952783 |
Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2. |
Recent Publications on UBE2V2: |  |
Biological significance of structural differences between two highly conserved Ubc variants.
Ubiquitin conjugating enzyme variants (Uev) Uev1 and Mms2 share >90%... | 23rd January, 2009
| Department of Microbiology and Immunology, University of Saskatchewan, 107
| Biochem Biophys Res Commun. 2009 Jan 16;378(3):563-8. Epub 2008 Dec 3.
DOI Direct Link |
DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex.
Many proteins involved in DNA replication and repair undergo... | 23rd May, 2008
| Radiation Biology Center, and Institute for Virus Research, Kyoto
| J Biol Chem. 2008 Apr 4;283(14):9071-9. Epub 2008 Feb 1.
DOI Direct Link |
Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.
Human helicase-like transcription factor (HLTF) is frequently inactivated... | 9th April, 2008
| Institute of Genetics, Biological Research Center, Hungarian Academy of
| Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3768-73. Epub 2008 Mar 3.
DOI Direct Link |
hMMS2 serves a redundant role in human PCNA polyubiquitination.
BACKGROUND: In yeast, DNA damage leads to the mono and polyubiquitination... | 21st March, 2008
| Centre for Cancer Therapeutics, Ottawa Health Research Institute, Ottawa,
| BMC Mol Biol. 2008 Feb 19;9:24.
DOI Direct Link |
A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine.
3-Methyl adenine (3meA), a minor-groove DNA lesion, presents a strong... | 19th February, 2008
| Department of Biochemistry and Molecular Biology, University of Texas
| Mol Cell Biol. 2007 Oct;27(20):7198-205. Epub 2007 Aug 13.
DOI Direct Link |
→View more research publications. |
UBE2V2 results (if any) from reagent suppliers | 
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Polyclonal Antibody to UBE2V2 (Ubiquitin E2 variant 2)/Mms2
This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is ...
http://www.imgenex.com/tds/IMG-400.pdf...
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UBE2V2 +UBE2V1 proteins and peptides: Cell Biology > Cell Cycle ...
UBE2V2 +UBE2V1 proteins and peptides. ... Image Abreview Publication. ab81567 · UBE2V2 +UBE2V1 protein (His tag). Conjugation, SDS-PAGE ...
http://www.abcam.com/index.html?t=281110&pt=2&c=3284&ei=&mu=...
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UBE2N antibody, UBE2N (ubiquitin-conjugating enzyme E2N (UBC13 ...
Function: The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. ...
http://www.genwaybio.com/product_info.php?products_id=42472...
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Mms2 (C-18) Antibody sc-19541
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, UBE2V2, 7336, 8q11.21, NM_003350 ...
http://www.scbt.com/datasheet-19541-mms2-c-18-antibody.html...
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Antibody : Imgenex Knowledgebase center
IMG-400 [Polyclonal Antibody to UBE2V2 (Ubiquitin E2 variant 2)/Mms2] · IMG-401A [Monoclonal Antibody to Cleaved PARP {poly (ADP-ribose) polymerase}] ...
http://www.imgenex.com/knowledgebase_cat.php?id=1...
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PCNA antibody, NUCLEAR ANTIGEN Antibody, Mouse Monoclonal Antibody
This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase
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http://www.genwaybio.com/product_info.php?products_id=73547...
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Ube2N antibody (ab25885) | Abcam
The Ube2V2/Ube2N heterodimer catalyzes the synthesis of non-canonical poly ubiquitin chains that are linked through Lys63. This type of poly ubiquitination
...
http://www.abcam.com/Ube2N-antibody-ab25885.html...
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