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VAV1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17716865 |
The data provide the first evidence of a role of glycerophosphoinositols as modulators of T-cell signaling and establish a mechanistic basis for the effects of this phosphoinositide derivative on F-actin dynamics. |
| 17590270 |
This review addresses the physiological function of wild-type Vav1, its mode of activation as an oncogene, and its emerging role as a transforming protein in human cancer. |
| 17550897 |
the calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes |
| 12917349 |
Vav1 trapping was independent of actin polymerization, suggesting that inhibition of cellular cytotoxicity occurs through an early dephosphorylation of Vav1 by SHP-1, which blocks actin-dependent activation signals. |
| 17237383 |
phosphorylation of the adaptor molecule SLP-76 is essential for recruitment of the exchange factor Vav leading to Ca(2+) flux and IL-2 production |
| 15618472 |
pivotal role for Vav in the transmission of the migratory signal through the chemokine receptor CXCR4 |
| 15699036 |
there is a phosphorylation-dependent association between beta(3) integrin and Vav1 which is essential for cell progression to a Rho-dominant phenotype during cell adhesion |
| 12386169 |
the interaction of Vav1 and Ly-GDI creates a fine tuning mechanism for the regulation of intracellular signaling pathways leading to NFAT stimulation |
| 14757747 |
although both Vav proteins are biochemically coupled to the T cell antigen receptor, they regulate distinct molecular pathways leading to defined gene transcriptional events. |
| 15652748 |
Data show that VAV1 is ectopically expressed in primary pancreatic adenocarcinomas due to demethylation of the gene promoter; identified as a growth-stimulatory protein in this disease | →View more information from publications. |
Recent Publications on VAV1: |  |
hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.
Sustained extracellular signal-regulated kinase (ERK)-signaling plays a... | 3rd November, 2009
| Department of Medicine, Immunotherapy Center, Medical College of Georgia,
| Int Immunol. 2009 Oct 30.
DOI Direct Link |
Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T Cell: Antigen presenting cell interactions.
The Gene Related to Anergy in Lymphocytes, GRAIL, is an E3 ubiquitin... | 17th October, 2009
| University of Wisconsin - Madison, United States.
| J Biol Chem. 2009 Oct 15.
DOI Direct Link |
Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT.
Adaptor protein c-Abl SH3 domain-binding protein-2 (3BP2, also referred to... | 17th October, 2009
| University of Fukui, Japan.
| J Biol Chem. 2009 Oct 15.
DOI Direct Link |
The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis.
Lung cancer is the leading cause of cancer death worldwide. The spectrum... | 10th October, 2009
| Hubert H Humphrey Centre for Experimental Medicine and Cancer Research,
| J Pathol. 2009 Sep;219(1):25-34.
DOI Direct Link |
Lipid rafts and caveolin-1 coordinate IL-1beta-dependent activation of NF-kappaB by controlling endocytosis of Nox2 and IL-1R1 from the plasma membrane.
Recent evidence suggests that signaling by the proinflammatory cytokine... | 6th October, 2009
| University of Iowa, United States.
| J Biol Chem. 2009 Oct 1.
DOI Direct Link |
→View more research publications. |
VAV1 results (if any) from reagent suppliers | 
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