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VAV2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17686471 |
Vav2 acts downstream of VEGF to activate Rac1. |
| 17234718 |
The EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most head and neck squamous cell carcinoma cells. |
| 15850391 |
Vav2-mediated nucleotide exchange of Rho GTPases follows the Theorell-Chance catalytic mechanism in which Vav2.Rho GTPase complex is the major species during the exchange process and Vav2.GDP-Mg2+.Rho GTPase ternary complex is present only transiently. |
| 11909943 |
Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. |
| 12810717 |
Vav2 and Tiam1 may act as downstream effectors of Src, thereby regulating Rac1-dependent pathways that participate in Src-induced cell transformation |
| 15345594 |
3BP2 may regulate b cell receptor-mediated gene activation through Vav proteins. |
| 11448999 |
Vav2 is a GDP/GTP exchange factor (GEF) for Rac in vivo. |
Recent Publications on VAV2: |  |
Distinct roles for Rho vs. Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.
Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis... | 15th October, 2009
| Univeristy of Nebraska Medical Center, United States;
| J Biol Chem. 2009 Oct 13.
DOI Direct Link |
Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats.
We previously demonstrated that the androgenic and anti-androgenic effects... | 29th September, 2009
| Laboratory of Veterinary Biochemistry and Molecular Biology, College of
| Reprod Biol Endocrinol. 2009 Sep 26;7:104.
DOI Direct Link |
Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells.
Increased intraglomerular pressure is an important hemodynamic determinant... | 17th September, 2009
| Division of Nephrology, McMaster University, Hamilton, Canada.
| Cell Signal. 2010 Jan;22(1):34-40. Epub 2009 Sep 13.
DOI Direct Link |
A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway.
RhoGEFs (guanine nucleotide exchange factors of the Rho GTPase family) are... | 11th September, 2009
| Centre de Recherche de Biochimie Macromoleculaire, Universites Montpellier
| Chem Biol. 2009 Jun 26;16(6):657-66.
DOI Direct Link |
Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo.
Vav guanine nucleotide exchange factors modulate changes in cytoskeletal... | 24th June, 2009
| Department of Medicine, Division of Rheumatology and Immunology,
| Mol Cancer Res. 2009 May;7(5):615-23. Epub 2009 May 12.
DOI Direct Link |
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