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VDAC1


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Symbol:VDAC1
Name(s):voltage-dependent anion channel 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC111064, PORIN, PORIN-31-HL
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17828567 Our analysis strongly suggests a 16-stranded, antiparallel beta-barrel with one large and seven short loops and turns. Initial crystallization trials of the protein yielded crystals diffracting to 8 Angstrom resolution.
12767928 Identification of the protein-protein contact site and interaction mode of VDAC1 with Bcl-2 family proteins.
16185087 evidences of VDAC-COX interaction in vitro proved to be functional as evidenced by the effect of the human and yeast isoforms of VDAC on the oxidation of cytochrome c by the pure holoenzyme and by the effect of the COX epitope on VDAC permeability
17254575 gelsolin G5 domain inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC
12736244 is a receptor for plasminogen kringle 5 on endothelial cells
16585511 VDAC1 regulates apoptosis independent of the apoptosis-inducing pathway.
12009301 interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74; results of this study represent additional evidence of membrane-associated trafficking of the voltage-dependent anion-selective channel 1
12118373 Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic protein Bim
17209561 Bcl-xL can bind to one or two VDAC1 molecules forming heterodimers and heterotrimers.
12698369 Presence of a plasma membrane VDAC was demonstrated. Colocalisation of VDAC with caveolin-1.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBCL2-associated X protein isoform betavoltage-dependent anion channel 1--Pubmed
HPRDBCL2-associated X protein isoform betavoltage-dependent anion channel 1--Pubmed
HPRDBCL2-like 1 isoform 1voltage-dependent anion channel 1--Pubmed
HPRDBCL2-like 1 isoform 1voltage-dependent anion channel 1--Pubmed
HPRDCreatine kinase mitochondrialvoltage-dependent anion channel 1--Pubmed
HPRDcreatine kinase, mitochondrial 1B precursorVDAC1--Pubmed
HPRDgelsolin isoform a precursorvoltage-dependent anion channel 1--Pubmed
HPRDgelsolin isoform a precursorvoltage-dependent anion channel 1--Pubmed
HPRDHexokinase 1voltage-dependent anion channel 1--Pubmed
HPRDhexokinase 1 isoform HKI-ta/tbVDAC1--Pubmed

Recent Publications on VDAC1:

Pubmed Logo
Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis.
BACKGROUND: The remodeled vessel wall in many vascular diseases such as...
30th October, 2009
Centre de Recherche de L'Hotel-Dieu de Quebec, 9 Rue McMahon, Quebec, Qc, Circulation. 2009 Sep 29;120(13):1231-40. Epub 2009 Sep 14.
DOI Direct Link
a new paradigm for mapk: structural interactions of herk1 with mitochondria in HeLa cells.
Extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) are members...
23rd October, 2009
Laboratory of Cellular Dynamics, Max Planck Institute for Biophysical PLoS One. 2009 Oct 22;4(10):e7541.
DOI Direct Link
Decreased expression of the voltage-dependent anion channel in differentiated PC-12 and SH-SY5Y cells following Low-level Pb exposure.
Lead (Pb) has been shown to disrupt cellular energy metabolism which may...
14th October, 2009
Center for Structural and Functional Neuroscience, Center for Toxicol Sci. 2009 Oct 12.
DOI Direct Link
VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.
Truncated BID (tBID), a proapoptotic BCL2 family protein, induces...
13th October, 2009
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson EMBO Rep. 2009 Oct 9.
DOI Direct Link
[Expression of the voltage-dependent anion channel gene in human ejaculated spermatozoa]
OBJECTIVE: To identify the genes involved in sperm motility. METHODS: We...
2nd October, 2009
Key Laboratory of Male Reproductive and Genetic Medicine, Peking Zhonghua Nan Ke Xue. 2009 Jun;15(6):493-8.

View more research publications.

BioNews Results for VDAC1

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VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria
International Journal of Impotence Research:  Oct 9 2009 5:14PM Matching: vdac1

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6962436 Digitizing temperature measurement system and method of operation
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6917189 Electric power supply unit having improved output voltage response

View more patents.

VDAC1 results (if any) from reagent suppliers

Google CSE Logo
VDAC1 antibody, VDAC1 (voltage-dependent anion channel 1) Antibody ...
Buy quality rabbit VDAC1 antibody (interacts with human), anti-VDAC1, VDAC1 ( voltage-dependent anion channel 1) antibody, rabbit polyclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=42624...

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VDAC/Porin antibody (ab28777) | Abcam
Rabbit polyclonal to VDAC/Porin. Voltage dependent anion selective channel protein 1 (VDAC/Porin) belongs to the eukaryotic mitochondrial porin family and
...
http://www.abcam.com/VDAC1-antibody-ab28777.html...

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VDAC1 (N-18) Antibody sc-8828
See how others have used VDAC1 (N-18): sc-8828 antibody and or VDAC1 (N-18) antibody ... Western blot analysis of VDAC1 expression in rat heart extract. ...
http://www.scbt.com/datasheet-8828-vdac1-n-18-antibody.html...

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VDAC1 / Porin antibody [20B12] - Mitochondrial Loading Control ...
Mouse monoclonal [20B12] to VDAC1 / Porin - Mitochondrial Loading Control. The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin) is an outer ...
http://www.abcam.com/VDAC1-Porin-antibody-20B12-Mitochondria...

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VDAC1 (C-20) Antibody sc-8829
VDAC1 shRNA (h) Lentiviral Particles, sc-42355-V, 200 µl ... See how others have used VDAC1 (C-20): sc-8829 antibody and or VDAC1 (C-20) antibody conjugates ...
http://www.scbt.com/datasheet-8829-vdac1-c-20-antibody.html...

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VDAC1/Porin - HRP antibody (HRP) (ab40747) | Abcam
Rabbit polyclonal to VDAC1/Porin - HRP (HRP). The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin) is an outer membrane mitochondrial protein
.
http://www.abcam.com/VDAC1-Porin-HRP-antibody-HRP-ab40747.ht...

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VDAC1 antibody, Rabbit anti Porin/VDAC Antibody, Rabbit Polyclonal ...
Buy quality rabbit VDAC1 antibody (interacts with n/a), anti-VDAC1, ... Rabbit anti Porin/VDAC; VDAC-1; hVDAC1; Outer mitochondrial membrane protein porin 1
...
https://www.genwaybio.com/product_info.php?products_id=24434...

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