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VEGFA


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Symbol:VEGFA
Name(s):vascular endothelial growth factor A
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC70609, VEGF, VEGF-A, VPF
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17948123 Data demonstrate that Notch1 and VEGFR-3 interact genetically, that Notch directly induces VEGFR-3 in blood endothelial cells to regulate vascular development, and that Notch and VEGF signaling may function in tumor lymphangiogenesis.
18190463 Increased levels of VEGF(vascular endothelial growth factor ) were found in the whole group of untreated patients with B non-Hodgkins lymphoma in comparison with normal controls
18239970 correlation of VEGF mRNA levels between primary tumor and liver metastasis.VEGF mRNA levels in liver metastasis were higher than in primary tumor.Cancer cells in liver metastasis may become more aggressive during metastasis.
18203080 These results indicate that TGF-Beta1-509 and VEGF-460 polymorphisms were not highly associated with the pathology of pterygium.
18186798 Present results suggest that VEGF gene 936 C/T polymorphism does not seem to be associated with susceptibility to familial Mediterranean fever and its clinical manifestations.
17920582 Mechanisms underlying GLP-2 induced intestinal wound repair seem to involve the secretion of VEGF and, subsequently, TGF-beta1 from subepithelial fibroblasts.
18079435 VEGFA participates in mammary tumor growth through both angiogenesis and nonangiogenic functions
18326231 Stromal sublayer of AA patients is characterized by low expression of Ang-1 and VCAM-1 genes and high VEGF expression compared to mean level of healthy donors.
18203080 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18223238 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDconnective tissue growth factorvascular endothelial growth factor--Pubmed
HPRDconnective tissue growth factorvascular endothelial growth factor--Pubmed
HPRDFibroblast growth factor 5vascular endothelial growth factor--Pubmed
HPRDfibroblast growth factor 5 isoform 1 precursorVEGF A--Pubmed
HPRDfms-related tyrosine kinase 1vascular endothelial growth factor--Pubmed
HPRDfms-related tyrosine kinase 1vascular endothelial growth factor--Pubmed
BINDfms-related tyrosine kinase 1vascular endothelial growth factor isoform b precursorVEGF-A interacts with VEGFR-1. This interaction was modeled on a demonstrated interaction between human VEGF-A and VEGFR-1 from an unspecified species.-Pubmed
BINDfms-related tyrosine kinase 1vascular endothelial growth factor isoform b precursorVEGF165 interacts with Flt-1. This interaction was modeled on a demonstrated interaction between human VEGF165 and Flt-1 from an unspecified species.-Pubmed
HPRDGlypican 1vascular endothelial growth factor--Pubmed
HPRDglypican 1 precursorVEGF A--Pubmed

Recent Publications on VEGFA:

Pubmed Logo
TNFalpha induces HIF-1alpha expression through activation of IKKbeta.
The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is...
3rd November, 2009
Department of Molecular and Cellular Oncology, The University of Texas Biochem Biophys Res Commun. 2009 Nov 27;389(4):640-4. Epub 2009 Sep 17.
DOI Direct Link
Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy.
BACKGROUND: Imatinib could reverse marrow angiogenesis and decrease the...
31st October, 2009
Department of Hematology/Medical Oncology, Chronic Myelogenous Leukemia Ann Oncol. 2009 Oct 29.
DOI Direct Link
Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGFA) gene and antidepressant treatment response in major depressive disorder.
Vascular endothelial growth factor (VEGF) has been implicated in...
30th October, 2009
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Psychiatry Res. 2009 Sep 30;169(2):113-7. Epub 2009 Aug 22.
DOI Direct Link
Stimulatory effects of thyroid hormone on brain angiogenesis in vivo and in vitro.
Thyroid hormone is critical for the proper development of the central...
29th October, 2009
Center for Brain Repair and Rehabilitation, Institute of Neuroscience and J Cereb Blood Flow Metab. 2009 Oct 28.
DOI Direct Link
Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma.
BACKGROUND: The von Hippel-Lindau gene (VHL) alteration, a common event in...
29th October, 2009
Department of Urology, Rennes University Hospital, Rennes, France. Br J Cancer. 2009 Oct 20;101(8):1417-24. Epub 2009 Sep 15.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Angiogenesis Using VEGF-A165/bFGF Plasmid Delivered Percutaneously in no-Option CAD Patients; a Controlled Trial

Patents:

Patents logo
US Patent No.Title
7605140 Regulation of angiogenesis with zinc finger proteins
7256178 Physiologically active substances
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof
7226755 HPTPbeta as a target in treatment of angiogenesis mediated disorders
7217509 Databases of regulatory sequences; methods of making and using same

View more patents.

VEGFA results (if any) from reagent suppliers

Google CSE Logo
VEGF (A-20) Antibody sc-152
See how others have used VEGF (A-20): sc-152 antibody and or VEGF (A-20) ... VEGF (A-20)-G: sc-152-G. Western blot analysis of human recombinant VEGF. ...
http://www.scbt.com/datasheet-152-vegf-a-20-antibody.html...

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Purified Anti-mouse VEGF-A Antibody Anti-VEGF-A - BioLegend
Purified Anti-mouse VEGF-A Antibody Anti-VEGF-A - VEGF-A, also known as VEGF ( vascular endothelial growth factor), is the founding member of the family ...
http://www.biolegend.com/purified-anti-mouse-vegf-a-antibody...

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Anti-Vascular Endothelial Growth Factor A Polyclonal Antibody
Polyclonal Antibody against Vascular Endothelial Growth Factor A for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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Human VEGFA BIOLISA Kit
The VEGFA BioLISA is an enzyme-linked immunosorbent assay for ... Active VEGFA present in the sample or standard binds to the receptors adsorbed to ...
http://www.cellsciences.com/PDF/650.040.096.pdf...

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VEGFA antibodies: Cancer > Growth factors > VEGF | Abcam
VEGFA antibodies. ... Image Abreview Publication. ab51745 · VEGFA antibody. WB, ELISA. Specific publication references. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=183336&pt=1&c=4227&ei=&mu=...

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VEGFA Goat Anti-Human Vascular Endothelial Growth Factor A ...
Goat Anti-human VEGFA polyclonal antibody. Formulation: ... Recombinant human VEGFA. Specificity: Recognizes human VEGFA. Alternate Names: ...
http://www.cellsciences.com/PDF/CPV107.pdf...

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VEGF (A-20) Antibody sc-152
VEGF (A-20): sc-152 antibody 및 VEGF (A-20) antibody conjugates를 사용한 논문 ... VEGF (A-20)-G: sc-152-G. Western blot analysis of human recombinant VEGF.
...
http://www.scbt.com/ko/datasheet-152-vegf-a-20-antibody.html...

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