Sunday November 22 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

VEGFC


Suggest Content
Advertise Here
Gene DB Home
Symbol:VEGFC
Name(s):vascular endothelial growth factor C
Type:protein-coding
Organism:Homo sapiens
Synonyms:Flt4-L, VRP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18061373 expression of VEGF-C in the margine of tumor is associated with lymphatic metastasis and prognosis and may induced lymphangiogenesis. VEGF-C was important in the regulation of angiogenesis and lymphangiogenesis in PAC.
18190720 COX-2 may up-regulate VEGF-C expression and thus promote lymph node metastasis via lymphangiogenesis pathway in human breast cancer.
18035072 Observational study of gene-disease association. (HuGE Navigator)
18057235 KSHV-infected endothelial cells are enriched, with VEGF-A and -C molecules playing key roles in KSHV biology.
17931169 The balance between expression of VEGF-C and VEGF-D at the invading colorectal tumour edge may enhance lymphatic metastasis, by promoting tumour lymphangiogenesis or by activation of pre-existing lymphatic vessels.
17686546 In non-small-cell lung cancer cells, VEGF-C/VEGFR-3 coexpression suggests an autocrine/paracrine loop responsible for a high proliferation rate in tumour cells.
17935478 data suggest that VEGF-C alters lymphatic endothelial function through a mechanism involving VEGFR-3
17640671 MMP-2, MMP-9, and vascular endothelial growth factor C were expressed to similar degrees at all time points in cells exposed to lymphatic flow.
17970036 the protein and mRNA levels of VEGF-C and VEGFR-3 were not significantly different in patients with or without metastasis.
16924525 results suggest the presence of lymphatic capillaries throughout the skeletal muscle, and present the localisation of VEGF-C and -D in the muscles.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BIND-vascular endothelial growth factor C preproproteinVEGF-C interacts with VEGFR-3. This interaction was modeled on a demonstrated interaction between human VEGF-C and VEGFR-3 from an unspecified species.-Pubmed
HPRDfms-related tyrosine kinase 4 isoform 1vascular endothelial growth factor C preproprotein--Pubmed
HPRDfms-related tyrosine kinase 4 isoform 1vascular endothelial growth factor C preproprotein--Pubmed
HPRDkinase insert domain receptorvascular endothelial growth factor C preproprotein--Pubmed
HPRDkinase insert domain receptorvascular endothelial growth factor C preproprotein--Pubmed
BINDkinase insert domain receptorvascular endothelial growth factor C preproproteinVEGF-C interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between human VEGF-C and VEGFR-2 from an unspecified species.-Pubmed
HPRDvascular endothelial growth factor C preproproteinvascular endothelial growth factor C preproprotein--Pubmed

Recent Publications on VEGFC:

Pubmed Logo
Highly sensitive multivariable assay detection of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes with melanoma micrometastases.
OBJECTIVES: To evaluate the prognostic value of melanocytic...
21st October, 2009
Unite Fonctionnelle Diagnostic Biologique Automatise, Centre National de Arch Dermatol. 2009 Oct;145(10):1105-13.
DOI Direct Link
Microarray analysis reveals potential target genes of NF-kappaB2/p52 in LNCaP prostate cancer cells.
PURPOSE: Our previous studies showed that NF-kappaB2/p52 is involved in...
15th October, 2009
Department of Urology, University of California Davis Medical Center, Prostate. 2009 Oct 13.
DOI Direct Link
Expression of vascular endothelial growth factors C and D correlates with lymphangiogenesis and lymph node metastasis in lung adenocarcinoma.
BACKGROUND: Vascular endothelial growth factors (VEGF)-C and -D have been...
3rd October, 2009
Thoracic Surgery, Second Hospital of Shandong University, 250033 Jinan, Thorac Cardiovasc Surg. 2009 Aug;57(5):291-4. Epub 2009 Jul 23.
DOI Direct Link
Existence of the lymphatic system in the primate corpus luteum.
To date, there have been no detailed studies on the lymphatic system in...
26th September, 2009
Division of Reproductive Sciences, Oregon National Primate Research Lymphat Res Biol. 2009;7(3):159-68.
DOI Direct Link
Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of rapamycin complex-2 and AKT-1.
Recurrence and subsequent metastatic transformation of cancer develops...
12th September, 2009
Department of Urologic Research, Mayo Clinic Cancer Center, Mayo Clinic Cancer Res. 2009 Aug 1;69(15):6042-8. Epub 2009 Jul 28.
DOI Direct Link

View more research publications.

Press Releases on VEGFC:

BioPortfolio Logo
Therapeutic activity of Bayer's BAY 43-9006 in renal cell carcinoma 1st January, 1970 Dailyupdates

Therapeutic activity of Bayer's BAY 43-9006 in renal cell carcinoma

Clinical Trials:

Clinical Trials Logo
Expression of VEGF-C and VEGF-CR in Oral Cancers and Premalignant Lesions

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7226908 Use of VEGF and homologues to treat neuron disorders
7176304 RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
7125856 Angiogenic growth factors for treatment of peripheral neuropathy
7081340 Gene expression profiling in biopsied tumor tissues

View more patents.

VEGFC results (if any) from reagent suppliers

Google CSE Logo
VEGFC antibody (ab9546) | Abcam
Rabbit polyclonal to VEGFC. Vascular endothelial growth factors (VEGFs), also known as vasculotropins, are a family of closely related growth factors having
...
http://www.abcam.com/VEGFC-antibody-ab9546.html...

Thumbshot
VEGF-C Antibody
However, upon proteolytic processing VEGF-C and -D gain the ability to also bind and activate ... recombinant human VEGF-C protein at various concentra- ...
http://www.cellsignal.com/pdf/2445.pdf...

Thumbshot
VEGF (C-1) Antibody sc-7269
See how others have used VEGF (C-1): sc-7269 antibody and or VEGF (C-1) antibody conjugates. displaying 1 - 5 of 76 results : < next 5 citations > ...
http://www.scbt.com/datasheet-7269-vegf-c-1-antibody.html...

Thumbshot
VEGF-C Antibody #2445
VEGF-C Antibody detects recombinant human VEGF-C protein at various concentrations. This antibody does not cross-react with other VEGF family
members. ...
http://www.cellsignal.com/products/2445.html...

Thumbshot
VEGF-C (F-10) Antibody sc-74585
VEGF-C (F-10): sc-74585. Western blot analysis of human recombinant VEGF-C. ... Western blot analysis of VEGF-C expression in RAW 264.7 whole cell lysate. ...
http://www.scbt.com/datasheet-74585-vegf-c-f-10-antibody.htm...

Thumbshot
VEGFC (VEGF3) Antibody (Center M263)
Vascular endothelial growth factor C [Precursor]; VEGF-C; Vascular endothelial growth factor-related protein; VRP; Flt4 ligand; Flt4-L; VEGFC; ...
http://www.abgent.com/products/catalog_no/AP2042c...

Thumbshot
VEGF-C (H-48) Antibody sc-25783
See how others have used VEGF-C (H-48): sc-25783 antibody and or VEGF-C ... Western blot analysis of VEGF-C expression in non-transfected: sc-117752 (A) and
...
http://www.scbt.com/datasheet-25783-vegf-c-h-48-antibody.htm...

Thumbshot

Search Bioportfolio and other Life Science Sites for VEGFC, or search for VEGFC on BioPortfolio's antibody search engine.
This page has been viewed 402 times
Recent Search Terms used to find this page:
vegf-c and lymphatic endothelial cell mmp | patente sc7133 | vegf-c biopharmaceutical | VEGF-C | mast cell VEGFR | vascular endothelial growth factor angiogenesis in 2009 | clinical trials vegfc | VEGF-C | VEGF-C vascular endothelial growth factor C | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.