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VIPR1


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Symbol:VIPR1
Name(s):vasoactive intestinal peptide receptor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ41949, HVR1, II, PACAP-R-2, RDC1, VAPC1, VIPR, VIRG, VPAC1, VPCAP1R
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17611633 The differential expression of VIPR1 in ulcerative colitis and Crohn's disease mucosa suggests that the VIP system plays different roles in the pathogenesis of inflammatory bowel disease.
11834941 VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection.
14599709 cloning and sequencing of 5' flanking region; VPAC1 may play a functional role in development of both cerebellum and adrenal medulla
16888206 MCF-7 cells have VPAC1 receptors that bound the VIP chemotherapeutic conjugate
16888207 observations provide additional evidence for a role of proapoptotic caspase adaptor protein and PAC1 R in the events determining the outcome of prostate cancer
16554109 Thr429 phosphorylation has a role in activation of human VPAC1
16520374 analysis of the two-step activation mechanism of VPAC receptor and of class II G protein-coupled receptors
16888162 125I-[Bpa28-vasoactive intestinal peptide] was covalently bonded to the 121-133 fragment within the N-terminal ectodomain of the receptor
16888167 Photoaffinity experiments clearly indicated that the 6-28 part of VIP physically interacts with the N-terminal ectodomain of VPAC1 receptor
11981043 a small sequence in the third intracellular loop of the VPAC(1) receptor is responsible for the efficient agonist-stimulated intracellular calcium concentration increase

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDcalmodulin 1vasoactive intestinal peptide receptor 1Calmodulin interacts with VIP1R.-Pubmed
HPRDGuanine nucleotide binding protein G(q) alpha subunitintestinal VIP receptor--Pubmed
HPRDguanine nucleotide binding protein, q polypeptideVasoactive intestinal peptide receptor 1--Pubmed
HPRDGuanine nucleotide binding protein G(S), alpha subunitintestinal VIP receptor--Pubmed
HPRDguanine nucleotide binding protein, alpha stimulating activity polypeptide 1 isoform cVasoactive intestinal peptide receptor 1--Pubmed
HPRDProthymosin alphaintestinal VIP receptor--Pubmed
HPRDprothymosin, alphaVasoactive intestinal peptide receptor 1--Pubmed
HPRDsecretin preproproteinintestinal VIP receptor--Pubmed
HPRDsecretin preproproteinintestinal VIP receptor--Pubmed
HPRDvasoactive intestinal peptide isoform 1 preproproteinintestinal VIP receptor--Pubmed

Recent Publications on VIPR1:

Pubmed Logo
Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene.
Idiopathic achalasia is a rare disorder of the oesophagus of unknown...
3rd November, 2009
Department of Cell Biology and Development, Sapienza University of Rome, Neurogastroenterol Motil. 2009 Jun;21(6):597-602. Epub 2009 Feb 27.
DOI Direct Link
Synaptic scaffolding molecule binds to and regulates vasoactive intestinal polypeptide type-1 receptor in epithelial cells.
BACKGROUND & AIMS: Vasoactive intestinal polypeptide (VIP) is a principal...
14th August, 2009
Department of Pharmacology and Brain Korea 21 Project for Medical Science, Gastroenterology. 2009 Aug;137(2):607-17, 617.e1-4.
A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia.
The association of HLA-B27 with ankylosing spondylitis (AS) is the...
13th August, 2009
Department of Cell Biology and Development, Sapienza University of Rome, Genes Immun. 2008 Dec;9(8):659-67. Epub 2008 Jul 31.
DOI Direct Link
Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice.
Among several factors known to modulate embryo implantation and survival,...
28th July, 2009
Immunopharmacology Laboratory, Department of Biological Chemistry, School Reproduction. 2009 Oct;138(4):733-42. Epub 2009 Jul 24.
DOI Direct Link
Grasping molecular structures through publication-integrated 3D models.
Although the need for communicating 3D data using simple and intuitive...
8th January, 2009
Institut fur Immungenetik, Charite-Universitatsmedizin Berlin, Campus Trends Biochem Sci. 2008 Sep;33(9):408-12. Epub 2008 Jul 30.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
6806054 Non-endogenous, constitutively activated known G protein-coupled receptors
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6969702 Compounds and methods for increasing neurogenesis
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

VIPR1 results (if any) from reagent suppliers

Google CSE Logo
Anti-VIP Receptor 1 - DISCONTINUED Polyclonal Antibody
Figure 1 shows a staining of VIPR1 in human adipose cells using OPA1-15073Z. ... 1 (VIPR1) expression has been documented widely in normal and cancerous ...
http://www.bioreagents.com/products/productDetails/productDe...

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VPAC1 (V-20) Antibody sc-31633
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, VIPR1, 7433, 3p22.1, NM_004624 ...
http://www.scbt.com/datasheet-31633-vpac1-v-20-antibody.html...

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Exalpha Biologicals, Inc.
Z135M, VipR 1 (Vasoactive Intestinal Peptide Rec-1), Monoclonal Antibody, AS58, 100 µg, $300, Datasheet (pdf) · Z140M, VipR 2 (Vasoactive Intestinal Peptide ...
http://www.exalpha.com/Searchresults1.php?menuvalue=Category...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
VIPR1; II; HVR1; RCD1; RDC1; VIPR; VIRG; VPAC1; PACAP-R-2 - VIP-R-1; Pituitary adenylate cyclase-activating polypeptide type II receptor; PACAP type II ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=V...

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VIPR2. Mouse cln AS69 Monoclonal
16 Sep 2002 ... There are 2 Vasoactive intestinal peptide receptors, VIPR1 and. VIPR2. ... and function of VIPR1 and VIPR2. VIPR1 on tumor cells mediates ...
http://www.exalpha.com/pdfs/Z140M.pdf...

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VPAC1 Antibody / VPAC1 Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. VPAC1 (2VIPR-2H8 ) Antibody, sc-81669, mouse IgG2a, WB, IF, FCM, h, r ...
http://www.scbt.com/ko/table-vpac1.html...

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Exalpha Biologicals, Inc.
X2114P, Vasoactive Intestinal Polypeptide Receptor 1 (VIPR1) ... Z135M, VipR 1 ( Vasoactive Intestinal Peptide Rec-1), Monoclonal Antibody, AS58, 100 µg ...
http://www.exalpha.com/Searchresults1.php?SearchTerm=test...

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