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VLDLR


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Gene DB Home
Symbol:VLDLR
Name(s):very low density lipoprotein receptor
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ35024, VLDLRCH
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17936586 Our findings suggest that peripheral VLDLR mRNA levels may serve as a reliable peripheral biological marker of schizophrenia, and that the reelin-VLDLR/ApoER2 signaling pathway plays a role in the pathophysiology of schizophrenia.
18039658 the activity of PCSK9 and its binding affinity on VLDLR and ApoER2 does not depend on the presence of LDLR.
11342683 Observational study of gene-disease association. (HuGE Navigator)
11931574 Observational study of gene-disease association. (HuGE Navigator)
12363388 Observational study of gene-disease association. (HuGE Navigator)
15953542 Observational study of gene-disease association. (HuGE Navigator)
16384981 Observational study of gene-disease association. (HuGE Navigator)
17854420 Meta-analysis of gene-disease association. (HuGE Navigator)
18056683 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17890782 VLDLR functions as a negative regulator of CNV, and this function is mediated through the wnt pathway.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDapolipoprotein E precursorvery low density lipoprotein receptor--Pubmed
HPRDapolipoprotein E precursorvery low density lipoprotein receptor--Pubmed
HPRDClusterinvery low density lipoprotein receptor--Pubmed
HPRDclusterinVLDL receptor--Pubmed
HPRDclusterin isoform 1VLDL receptor--Pubmed
HPRDDAB1very low density lipoprotein receptor--Pubmed
HPRDdisabled homolog 1VLDL receptor--Pubmed
HPRDlipoprotein lipase precursorvery low density lipoprotein receptor--Pubmed
HPRDlipoprotein lipase precursorvery low density lipoprotein receptor--Pubmed
HPRDlow density lipoprotein receptor-related protein associated protein 1very low density lipoprotein receptor--Pubmed

Recent Publications on VLDLR:

Pubmed Logo
Peroxisome proliferator-activated receptor gamma (PPAR{gamma}) regulates the expression and Function of very low density lipoprotein receptor.
Very low density lipoprotein receptor is a member of the low density...
29th October, 2009
1Vanderbilt University. Am J Physiol Endocrinol Metab. 2009 Oct 27.
DOI Direct Link
Reelin signaling antagonizes beta-amyloid at the synapse.
Abnormal processing of the amyloid precursor protein (APP) and...
7th October, 2009
Department of Molecular Genetics, University of Texas Southwestern Medical Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15938-43. Epub 2009 Sep 2.
DOI Direct Link
Thrombospondins function as regulators of angiogenesis.
Thrombospondins (TSPs) -1 and -2 were among the first protein inhibitors...
3rd October, 2009
Departments of Biochemistry and Medicine, University of Washington, J Cell Commun Signal. 2009 Oct 2.
DOI Direct Link
Mechanism for endogenously expressed APOE modulation of adipocyte VLDL metabolism: role in endocytic and lipase-mediated metabolic pathways.
Triglyceride-rich lipoproteins distribute energy in the form of fatty...
22nd September, 2009
University of Illinois at Chicago, United States. J Biol Chem. 2009 Sep 18.
DOI Direct Link
Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge.
The extracellular matrix protein Reelin, secreted by Cajal-Retzius (CR)...
2nd September, 2009
Institut fur Anatomie und Zellbiologie; Albert-Ludwigs-Universitat Commun Integr Biol. 2009 Jul;2(4):375-7.

View more research publications.

Press Releases on VLDLR:

BioPortfolio Logo
Alzheimer's Gene Slows Brain's Ability to Export Toxic Protein 14th November, 2008 University of Rochester Medical Center

ROCHESTER, N.Y., Nov. 14 /PRNewswire-USNewswire/ -- The only known genetic risk factor for Alzheimer's disease slows down the brain's ability to export a toxic protein known as amyloid

Patents:

Patents logo
US Patent No.Title
5652224 Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
6271341 Transcriptional activators with graded transactivation potential
6252136 Transgenic organisms having tetracycline-regulated transcriptional regulatory systems
6242667 Transgenic organisms having tetracycline-regulated transcriptional regulatory systems
6174527 Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism

View more patents.

VLDLR results (if any) from reagent suppliers

Google CSE Logo
VLDLR Antibody / VLDLR Antibodies
VLDLR Antibody / VLDLR Antibodies. ... VLDLR specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-vldlr.html...

Thumbshot
Dab1 Antibody #3328
Reelin is a secreted glycoprotein that binds to the lipoprotein receptors VLDLR and ApoER2 or alpha3beta1 integrin on the surface of neurons (1,2). ...
http://www.cellsignal.com/products/3328.html...

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VLDLR (6A6) Antibody sc-18824
See how others have used VLDLR (6A6): sc-18824 antibody and or VLDLR (6A6) ... Western blot analysis of VLDLR expression in HeLa (A) and A-10 (B) whole cell
...
http://www.scbt.com/datasheet-18824-vldlr-6a6-antibody.html...

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Dab1 Antibody
protein that binds to the lipoprotein receptors VLDLR and. ApoER2 or α3ß1 integrin on the surface of ... independent of VLDLR and ApoER2 (3). It has been
...
http://www.cellsignal.com/pdf/3328.pdf...

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VLDLR (1H10) Antibody sc-81698
mouse monoclonal IgG1, 100µg/ml; raised against VLDLR of human origin, with epitope mapping to ... VLDLR shRNA (h) Lentiviral Particles, sc-36822-V, 200 µl
...
http://www.scbt.com/datasheet-81698-vldlr-1h10-antibody.html...

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Dab1 antibody, Dab1 phospho Y198 Antibody, Rabbit Polyclonal Antibody
Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 ...
http://www.genwaybio.com/product_info.php?products_id=197449...

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VLDLR Antibody / VLDLR Antibodies
VLDLR Antibody / VLDLR Antibodies. ... VLDLR spezifische siRNA, sHRNA Plasmide und shRNA Lentivirale Partikel Gen Silencer sind ebenfalls erhältlich. ...
http://www.scbt.com/de/table-vldlr.html...

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