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VWF


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Gene DB Home
Symbol:VWF
Name(s):von Willebrand factor
Type:protein-coding
Organism:Homo sapiens
Synonyms:F8VWF, VWD
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18347221 VWF is not only a marker but also actually an important effector in the pathogenesis of myocardial infarction. Review.
18042361 In hypertriglyceridemia VWF elevation is a result of endothelial activation and subsequent mobilization of VWF from the arterial wall.
17901248 ADAMTS13 preferentially acts on platelet-VWF complexes under fluid shear stress
11236861 Observational study of genotype prevalence. (HuGE Navigator)
11722428 Observational study of gene-disease association. (HuGE Navigator)
11736957 Observational study of gene-disease association. (HuGE Navigator)
11755948 Observational study of gene-disease association. (HuGE Navigator)
12082590 Observational study of gene-disease association. (HuGE Navigator)
12091053 Observational study of genotype prevalence. (HuGE Navigator)
12381897 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha 1 type I collagen preproproteinvon Willebrand factor precursor--Pubmed
HPRDalpha 1 type I collagen preproproteinvon Willebrand factor precursor--Pubmed
HPRDalpha 2 type I collagenvon Willebrand factor precursor--Pubmed
HPRDalpha 2 type I collagenvon Willebrand factor precursor--Pubmed
HPRDCoagulation factor VIIIvon Willebrand factor precursor--Pubmed
HPRDcoagulation factor VIII isoform a precursorvon Willebrand factor--Pubmed
HPRDGlycoprotein Ib, platelet, alpha polypeptidevon Willebrand factor precursor--Pubmed
HPRDplatelet glycoprotein Ib alpha polypeptide precursorvon Willebrand factor--Pubmed
HPRDheat shock 70kDa protein 5von Willebrand factor precursor--Pubmed
HPRDheat shock 70kDa protein 5von Willebrand factor precursor--Pubmed

Recent Publications on VWF:

Pubmed Logo
Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.
ADAMTS13 specifically cleaves plasma von Willebrand factor (VWF) and...
3rd November, 2009
National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Proc Natl Acad Sci U S A. 2009 Oct 30.
DOI Direct Link
Identification of a Novel 14-3-3{zeta} Binding Site Within the Cytoplasmic Domain of Platelet Glycoprotein Ib{alpha} That Plays a Key Role in Regulating the von Willebrand Factor Binding Function of Glycoprotein Ib-IX.
Rationale: The interaction between platelet glycoprotein (GP)Ib-IX and von...
31st October, 2009
School of Biological Science and Medical Engineering, Beijing University Circ Res. 2009 Oct 29.
DOI Direct Link
Functional association of PI3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex.
Summary Background: The adhesion receptor glycoprotein (GP)Ib-IX-V, that...
31st October, 2009
Australian Centre for Blood Diseases, Monash University, Alfred Medical J Thromb Haemost. 2009 Oct 30.
DOI Direct Link
The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules.
Summary Background: The glycoprotein (GP) Ib-IX-V complex attaches...
31st October, 2009
from Puget Sound Blood Center, and Hematology Division (Medicine), J Thromb Haemost. 2009 Oct 23.
DOI Direct Link
The plasma Von Willebrand Factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs.
Summary. Background: Von Willebrand Factor (VWF) is a key component for...
31st October, 2009
Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial J Thromb Haemost. 2009 Oct 24.
DOI Direct Link

View more research publications.

BioNews Results for VWF

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BioPortfolio Logo
Relationship of indices of inflammation and thrombogenesis to arrhythmia burden in paroxysmal atrial fibrillation
CHEST:  Oct 27 2009 2:16AM Matching: vwf
Ablynx Wins Award For 'most Successful Early Phase Trial'
Genetic Engineering News:  Oct 23 2009 5:53PM Matching: vwf
Ablynx Wins Award For 'Most Successful Early Phase Trial'
BioSpace:  Oct 23 2009 5:49PM Matching: vwf
Inflammatory markers increased in bipolar disorder and schizophrenia
MedWire News:  Oct 22 2009 12:59AM Matching: vwf
Ablynx Initiates Phase II Clinical Trial For ALX-0081
BioPortfolio:  Sep 1 2009 6:19PM Matching: vwf
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Study of a Plasma-Derived Von Willebrand Factor/Factor VIII Concentrate (vWF/FVIII), Biostate®, in Subjects With Von Willebrand Disease

Patents:

Patents logo
US Patent No.Title
7524826 Method of inhibiting the generation of active thrombin on the surface of a cell within an atherosclerotic plaque
7557188 Methods of treating blood coagulation disorders using a pharmaceutical preparation comprising vWF propeptide
7560107 Modified factor VIII
7560276 Soft tissue repair and regeneration using postpartum-derived cells
7563278 Drug-eluting intravascular prostheses and methods of use

View more patents.

VWF results (if any) from reagent suppliers

Google CSE Logo
Von Willebrand Factor antibody (FITC) (ab8822) | Abcam
Sheep polyclonal to Von Willebrand Factor (FITC). Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen.
http://www.abcam.com/Von-Willebrand-Factor-antibody-FITC-ab8...

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VWF Antibody / VWF Antibodies
VWF Antibody / VWF Antibodies. ... VWF specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-vwf.html...

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Anti-von Willebrand Factor Polyclonal Antibody
Polyclonal Antibody against von Willebrand Factor for use in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
http://www.bioreagents.com/products/productDetails/productDe...

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VWF (H-300) Antibody sc-14014
See how others have used VWF (H-300): sc-14014 antibody and or VWF (H-300) antibody ... Western blot analysis of VWF expression in human platelet extract.
...
http://www.scbt.com/datasheet-14014-vwf-h-300-antibody.html...

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Von Willebrand Factor antibody [F8/86] (ab778) | Abcam
Mouse monoclonal [F8/86] to Von Willebrand Factor. Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen.
http://www.abcam.com/Von-Willebrand-Factor-antibody-F8-86-ab...

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VWF (4F9) Antibody sc-59957
VWF shRNA (h) Lentiviral Particles, sc-36828-V, 200 µl ... Western blot analysis of VWF expression in human platelet (A) and HUV-EC-C (B) whole cell lysates ...
http://www.scbt.com/datasheet-59957-vwf-4f9-antibody.html...

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Anti-von Willebrand Factor Monoclonal Antibody
Monoclonal Antibody against von Willebrand Factor for use in ELISA, Western Blot .
http://www.bioreagents.com/products/productDetails/productDe...

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