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WARS


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Gene DB Home
Symbol:WARS
Name(s):tryptophanyl-tRNA synthetase
Type:protein-coding
Organism:Homo sapiens
Synonyms:GAMMA-2, IFI53, IFP53
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17999956 the annexin II-S100A10 complex, which regulates exocytosis, forms a ternary complex with TrpRS.
18180246 Analysis of the molecular basis of the mechanisms of the substrate recognition and the activation reaction by tryptophanyl-tRNA synthetase.
15939065 Observational study of gene-disease association. (HuGE Navigator)
17877375 Results provide the first evidence of the involvement of heme in regulation of TrpRS aminoacylation activity.
11834741 Recognition by tryptophanyl-tRNA synthetases of discriminator base on tRNATrp from three biological domains
16798914 The first crystal structure of human tryptophanyl-tRNA synthetase (hTrpRS) in complex with tRNA(Trp) and Trp which, together with biochemical data, reveals the molecular basis of a novel tRNA binding and recognition mechanism.
11773625 In this study, we show that a recombinant form of a COOH-terminal fragment of TrpRS is a potent antagonist of vascular endothelial growth factor-induced angiogenesis in a mouse model and of naturally occurring retinal angiogenesis in the neonatal mouse
14630953 TrpRS may have a role in the maintenance of vascular homeostasis
12416978 The recently discovered antiangiogenic and cell-signaling activities of tryptophanyl-tRNA synthetase bioactive fragments are discussed in this review.
14660560 results suggest that mammalian and bacterial tryptophanyl-tRNA synthetase might use different mechanisms to recognize the substrate and modeling studies indicate that transfer RNA binds with the dimeric enzyme

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDeukaryotic translation elongation factor 1 alpha 1Human tryptophanyl-tRNA synthetase mRNA, and translated productsWRS interacts with EF-1-alpha.-Pubmed

Recent Publications on WARS:

Pubmed Logo
Documenting the health consequences of endemic warfare in three pastoralist communities of northern Kenya: A conceptual framework.
Violent conflict represents the third most important source of mortality...
3rd November, 2009
University of Arizona, Anthropology, 1009 E South Campus Drive, Tucson, AZ Soc Sci Med. 2009 Oct 30.
DOI Direct Link
Prehospital paediatric emergency care: paediatric triage.
The practice of triage was conceived during the Napoleonic wars, with the...
24th October, 2009
Department of Child Health, Poole Hospital NHS Foundation Trust, Longfleet Emerg Med J. 2009 Nov;26(11):767-8.
DOI Direct Link
Pain Following Battlefield Injury and Evacuation: A Survey of 110 Casualties from the Wars in Iraq and Afghanistan.
ABSTRACT Objective. Advances in regional anesthesia, specifically...
22nd October, 2009
Uniformed Services University of the Health Sciences, Bethesda, Maryland. Pain Med. 2009 Oct 14.
DOI Direct Link
"Initiate-Build-Operate-Transfer"- A Strategy for Establishing Sustainable Telemedicine Programs in Developing Countries: Initial Lessons from the Balkans.
Establishing sustainable telemedicine has become a goal of many developing...
17th October, 2009
Alaska Native Medical Center, Anchorage, Alaska. Telemed J E Health. 2009 Oct 15.
DOI Direct Link
The first 83 and the next 83: perspectives on neurotoxicology.
This commentary depicts the author's history, and how it became interwoven...
14th October, 2009
Department of Environmental Medicine, Environmental Health Sciences Neurotoxicology. 2009 Sep;30(5):832-50. Epub 2009 Feb 7.
DOI Direct Link

View more research publications.

BioNews Results for WARS

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BioPortfolio Logo
State confirms death related to swine flu
KPVI:  Nov 13 2009 2:47PM Matching: wars
Children Deaf From Gaza Wars Healed By Visiting Surgeon
MedIndia:  Nov 12 2009 6:07PM Matching: wars
Out of Africa: The Tobacco War's New Battleground (source: Scientific American)
WOWT:  Nov 12 2009 4:38PM Matching: wars
Out of Africa: The Tobacco War's New Battleground
Scientific American:  Nov 12 2009 4:24PM Matching: wars
LCA launches webpage with information on lung cancer meant for veterans
News-Medical.Net:  Nov 12 2009 6:50AM Matching: wars
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans

Patents:

Patents logo
US Patent No.Title
7548198 Method and system for providing preference based location aware content
7572186 Virtual cameras and 3-D gaming environments in a gaming machine
7572187 Video game environment that tracks help and advice provided to other player characters
7574000 System and method for analysing communications streams
7577250 Key derivation functions to enhance security

View more patents.

WARS results (if any) from reagent suppliers

Google CSE Logo
TrpRS (H-300) Antibody sc-48810
Human, WARS, 7453, 14q32.2, NM_004184, NM_173701, NM_213645, NM_213646 · P23381 · 191050. Mouse, Wars, 22375, 12 F1, P32921 ...
http://www.scbt.com/datasheet-48810-trprs-h-300-antibody.htm...

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Antibodies Incorporated
The prevalence of this organism seems to be rising as more and more veterans of our Middle East wars are being found positive for Blastocystis. ...
http://www.antibodiesinc.com/...

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Monthly Newsletter
Foxp3 Clone Wars. Figure legend: Cells were separated with Ficoll from blood of healthy donors and stained with BioLegend Foxp3 antibody (clone 206D, ...
http://www.biolegend.com/media_assets/literature/images/Lege...

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Cayman Chemical | PGC-1 Polyclonal Antibody | Description • PPARγ ...
1 Jun 2005 ... 5 Flier, J.S. Obesity wars: Molecular progress confronts an expanding epidemic. Cell 116 337-350 (2004). ...
http://www.caymanchem.com/app/template/Product.vm/catalog/10...

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Synapsin Ia/b (C-20) Antibody sc-8295
Acta Neurobiol Exp (Wars). 63: 185-195. View PubMed Entry. Tavares, A. et al. 2001. Profile of phosphoprotein labelling in organotypic slice cultures of rat
...
http://www.scbt.com/datasheet-8295-synapsin-ia-b-c-20-antibo...

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GFAP antibody - Astrocyte Marker (ab7779) | Abcam
Acta Neurobiol Exp (Wars) 69:12-23 (2009). ICC/IF; Human. PubMed: 19325637. See all 4 publication references for this product. ...
http://www.abcam.com/gfap-antibody-astrocyte-marker-ab7779.h...

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Promega eNotes - Feature
"Star Wars". William Linton founds Biotec, a company that provided restriction enzymes ... War erupts in Kosovo. JBL Scientific, Incorporated, a specialty ...
http://www.promega.com/enotes/features/fe0016_tabs.htm...

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