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WHSC1
| Symbol: | WHSC1 | | Name(s): | Wolf-Hirschhorn syndrome candidate 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLJ23286, KIAA1090, MGC176638, MMSET, NSD2, REIIBP, TRX5, WHS | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17942756 |
that MMSET plays a significant role in t(4;14) MM and suggest that therapies targeting this gene could impact this particular subset of poor-prognosis patients. |
| 18036184 |
MM Patients showing the t(4;14) chromosomal translocation at FGFR3 and MMSET genes had a significant elevation of serum crosslaps, reported to be the marker most reliably correlated with the extent of bone resorption |
| 12433679 |
data indicate that t(4;14)(p16;q32) and loss of fibroblast growth factor receptor 3 occurred at a very early stage of multiple myeloma and suggest that activation of multiple myeloma SET domain protein may be transforming event of this translocation |
| 15677557 |
different transcripts detected, multiple myeloma SET domain containing protein (MMSET I), MMSET II, Exon 4a/MMSET III, and response element II binding protein (RE-IIBP), are produced by alternative splicing |
| 12715353 |
connection between the syndrome phenotype and cytogenetic abnormalities, through gradual shortening of the length of the critical region WHSCR (finally up to 165 kb), and sequencing it, at least 2 genes (WHSC1 and WHSC2) were identified. |
| 16682010 |
Overexpression of WHISTLE repressed transcription of the SV40 promoter. Our results suggest that WHISTLE is a novel SET domain containing a protein with specific H3K4 and H3K27 HMTase activity. |
| 17239852 |
Our results suggest that HMTase WHISTLE induces apoptosis in an HMTase activity-dependent manner and represses transcription of target genes through HDAC1 recruitment. |
Recent Publications on WHSC1: |  |
Wolf-Hirschhorn syndrome facial dysmorphic features in a patient with a terminal 4p16.3 deletion telomeric to the WHSCR and WHSCR 2 regions.
We report on a patient with developmental delay and several facial... | 3rd October, 2008
| 1Department of Medical Genetics, Wilhelmina Children's Hospital,
| Eur J Hum Genet. 2008 Oct 1.
DOI Direct Link |
Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas.
Dynamic changes in the expression of multiple genes appear to be common... | 22nd May, 2008
| Surgical Neurology Branch, National Institute of Neurological Disorders
| Neuro Oncol. 2008 Feb;10(1):45-51. Epub 2008 Jan 8.
DOI Direct Link |
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor.
MMSET, identified by its fusion to the IgH locus in t(4;14)-associated... | 26th April, 2008
| Division of Hematology/Oncology, Mount Sinai School of Medicine, New York,
| Blood. 2008 Mar 15;111(6):3145-54. Epub 2007 Dec 21.
DOI Direct Link |
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.
Histone methylation is crucial for transcriptional regulation and... | 23rd April, 2008
| Department of Life Science, College of Natural Sciences, Chung-Ang
| Mol Cell Biol. 2008 Mar;28(6):2023-34. Epub 2008 Jan 2.
DOI Direct Link |
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.
Multiple myeloma (MM) is an incurable hematologic malignancy characterized... | 12th March, 2008
| Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School
| Blood. 2008 Jan 15;111(2):856-64. Epub 2007 Oct 17.
DOI Direct Link |
→View more research publications. |
WHSC1 results (if any) from reagent suppliers | 
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WHSC1/NSD2 antibodies | Abcam
WHSC1/NSD2 antibodies. ... Image Abreview Publication. ab28470 · WHSC1/NSD2 antibody. WB, ELISA. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=29273&pt=1&c=3570...
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W-X-Y-Z
HPA015801, Anti-WHSC1 antibody produced in rabbit New, affinity isolated antibody, human ... WHSC1(7468), human, IHC (p), PA, WB ...
https://www.sigmaaldrich.com/etc/controller/controller-page....
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WHSC1/NSD2 proteins and peptides | Abcam
WHSC1/NSD2 proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab32671 · WHSC1/NSD2 peptide ...
http://www.abcam.com/index.html?t=29273&pt=2&c=563...
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NSD2 (N-20) Antibody sc-50148
Number. Human, WHSC1, 7468, 4p16.3, NM_007331, NM_133330, NM_133331, NM_133334, NM_133335, NM_133336 · O96028 · 602952. Mouse, Whsc1, 107823, 5 B2, Q8BVE8 ...
http://www.scbt.com/datasheet-50148-nsd2-n-20-antibody.html...
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WHSC1/NSD2 peptide (ab32671) reviews | Abcam
WHSC1/NSD2 peptide. Wolf-Hirschhorn syndrome (WHS) is defined by a collection of core characteristics, which include mental retardation, epilepsy, ...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=3...
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WHSC1L1 Antibody (C-term)
Histone-lysine N-methyltransferase NSD3; Nuclear SET domain-containing protein 3 ; WHSC1-like protein 1; Wolf-Hirschhorn syndrome candidate 1-like protein 1; ...
http://www.abgent.com/products/catalog_no/AP1904a...
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Cancer - Protein and Antibody Solutions Provider - GenWay
18-003-42383, WHSC1 (Wolf-Hirschhorn syndrome candidate 1) - WHSC1; KIAA1090, MMSET, NSD2, REIIBP, TRX5 - EC 2.1.1.43; Nuclear SET domain-containing protein
...
https://www.genwaybio.com/index.php?cPath=4002&fl=W...
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Chromosome 4 - Santa Cruz Biotechnology, Inc.
WHSC1 · 7468, 4p16.3, NM_133330 · O96028 · NSD2 · sc-61233, TSA, 602952 · WHSC1 · 7468, 4p16.3, NM_133331 · O96028 · NSD2 · sc-61233, TSA, 602952 ...
http://www.scbt.com/chromosome.php?number=4...
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SI01100 MISSION siRNA Human Gene Family Panels Ligase Panel, 949 ...
... USPL1(10208), VPS11(55823), VPS13D(55187), VPS41(27072), VPS8(23355), WDR24( 84219), WDR59(79726), WDSUB1(151525), WHSC1(7468), WHSC1L1(54904), ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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NSD Antibody / NSD Antibodies
검색. 상세검색. 카탈로그 보기, Protein A, G PLUS or L-Agarose, Alexa Fluor® Conjugated Primary Antibodies, Tumor Suppressors/Apoptosis Antibodies ...
http://www.scbt.com/ko/table-nsd.html...
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