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XPC


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Gene DB Home
Symbol:XPC
Name(s):xeroderma pigmentosum, complementation group C
Type:protein-coding
Organism:Homo sapiens
Synonyms:XP3, XPCC
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18285822 Meta-analysis of gene-disease association. (HuGE Navigator)
18320070 Observational study of gene-disease association. (HuGE Navigator)
18177054 NMR analysis indicates that the physical interaction between C-XPC and centrin 2 induces only minor conformational changes into XPC, localized around the 17-mer segment (847-863), showed to be critically involved in the centrin binding.
16086280 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16258177 Observational study of gene-disease association. (HuGE Navigator)
16284373 Observational study of gene-disease association. (HuGE Navigator)
16351803 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16373199 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
16393248 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcaltractinxeroderma pigmentosum, complementation group C--Pubmed
HPRDcaltractinxeroderma pigmentosum, complementation group C--Pubmed
BINDdamage-specific DNA binding protein 2xeroderma pigmentosum, complementation group CDDB2 interacts with XPC. This interaction was modeled on a demonstrated interaction between human DDB2 and hamster XPC.-Pubmed
HPRDERCC3xeroderma pigmentosum, complementation group C--Pubmed
HPRDexcision repair cross-complementing rodent repair deficiency, complementation group 3Xeroderma pigmentosum group C complementing protein--Pubmed
HPRDRAD23Axeroderma pigmentosum, complementation group C--Pubmed
HPRDUV excision repair protein RAD23 homolog AXeroderma pigmentosum group C complementing protein--Pubmed
HPRDRAD23Bxeroderma pigmentosum, complementation group C--Pubmed
HPRDUV excision repair protein RAD23 homolog BXeroderma pigmentosum group C complementing protein--Pubmed
HPRDthymine-DNA glycosylasexeroderma pigmentosum, complementation group C--Pubmed

Recent Publications on XPC:

Pubmed Logo
Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors.
Gene-environment interactions determine inter-individual variations in...
3rd November, 2009
Department of Health Risk Analysis and Toxicology, Nutrition and Br J Nutr. 2009 Nov 2:1-12.
DOI Direct Link
Structure, Dynamics and Thermodynamics of the Human Centrin 2/hSfi1 Complex.
Centrin, an EF-hand calcium-binding protein, has been shown to be involved...
28th October, 2009
Institut Curie-Centre de Recherche, F-91405 Orsay Cedex, France; Institut J Mol Biol. 2009 Oct 24.
DOI Direct Link
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
Chromatin modifications are an important component of the of DNA damage...
16th October, 2009
Department of Genetics, Center for Biomedical Genetics, Erasmus Medical J Cell Biol. 2009 Sep 21;186(6):835-47.
DOI Direct Link
Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice.
UV-irradiated skin and UV-induced tumors overexpress the inducible isoform...
8th October, 2009
Department of Dermatology, Boston University School of Medicine, MA 02118, Am J Pathol. 2009 Nov;175(5):1952-61. Epub 2009 Oct 1.
DOI Direct Link
hSNF5/INI1, a Component of the Human SWI/SNF Chromatin Remodeling Complex, Promotes Nucleotide Excision Repair by Influencing ATM Recruitment and Downstream H2AX Phosphorylation.
Recent studies have implicated the role of the SWI/SNF ATP-dependent...
7th October, 2009
Department of Radiology, Department of Molecular and Cellular Mol Cell Biol. 2009 Oct 5.
DOI Direct Link

View more research publications.

Press Releases on XPC:

BioPortfolio Logo
Detroit Clinic Owner Pleads Guilty in Medicare Fraud Scheme 30th October, 2009 U.S. Department of Justice

WASHINGTON, Oct. 30 /PRNewswire-USNewswire/ -- Miami resident Daisy Martinez pleaded guilty today in U.S. District Court in Detroit to participating in a conspiracy to defraud the Medicare

Patents:

Patents logo
US Patent No.Title
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7338807 Screening assays for compounds that cause apoptosis
7358090 Establishment of cellular manipulations which enhance oligo-mediated gene targeting
7363165 Significance analysis of microarrays
7366765 Outboard clustered computer systems manager utilizing commodity components

View more patents.

XPC results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
XPC antibodies. ... XPC antibody [3.26]. IHC-P, WB, ICC/IF. Images · Customer Abreviews: 4 stars (out of 5) · Specific publication references ...
http://www.abcam.com/index.html?t=9459&pt=1&c=875...

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XPC Antibody Bethyl Laboratories
Defects in XPC are a cause of xeroderma pigmentosum complementation group C, a rare autosomal recessive diseased characterized by hypersensitivity to ...
http://www.bethyl.com/go/?product/A301-121A...

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XPC (H-300) Antibody sc-30156
See how others have used XPC (H-300): sc-30156 antibody and or XPC (H-300) antibody ... Impact of arsenic on nucleotide excision repair: XPC function, ...
http://www.scbt.com/datasheet-30156-xpc-h-300-antibody.html...

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XPC antibody [3.26] (ab6264) | Abcam
Mouse monoclonal [3.26] to XPC. Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the ...
http://www.abcam.com/XPC-antibody-3-26-ab6264.html...

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XPC Antibody / XPC Antibodies
XPC Antibody / XPC Antibodies. ... XPC specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-xpc.html...

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Antibody Products - Protein and Antibody Solutions Provider - GenWay
XPC; XPCC Xeroderma pigmentosum complementation group C XP3 XP 3 XP-3 - Mouse monoclonal antibody to human XPC protein; XPCC Xeroderma pigmentosum ...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=X...

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XPC (D-10) Antibody sc-74410
XPC shRNA (h) Lentiviral Particles, sc-37805-V, 200 µl ... Western blot analysis of XPC expression in Hs68 (A) and Raji (B) whole cell lysates. Download ...
http://www.scbt.com/datasheet-74410-xpc-d-10-antibody.html...

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