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XPO1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17869244 |
Ihe subcellular localization of MSH4 is regulated by an active nuclear export pathway dependent on the exportin CRM1;CRM1 is also involved in MSH5 nuclear export. |
| 17711849 |
CRM1 may down-regulate Cdc7 by masking its kinase domain |
| 17764157 |
We found no evidence that Crk II bound to Crm1 nor that the localization of GFP-Crk II was sensitive to LMB, an inhibitor of Crm1. |
| 17715235 |
human cytomegalovirus tegument protein pp65 nuclear export requires cyclin-dependent kinase activity and the Crm1 exporter |
| 17726064 |
Inhibition of exportin-1-mediated nuclear export slowed down nucleocytoplasmic shuttling of v-Src-activated STAT3 resulting in reduced tyrosine phosphorylation, decreased induction of STAT3 target genes and increased apoptosis. |
| 9368759 |
CRM1 is a member of the importin-beta family of proteins |
| 17405816 |
The export receptor CRM1 is a key player in the molecular mechanism for maintaining snRNP trafficking pathways. |
| 12196506 |
Reconstitution of nuclear protein export in isolated nuclear envelopes |
| 12134013 |
The carboxy-terminal region of the human immunodeficiency virus type 1 protein Rev has multiple roles in mediating CRM1-related Rev functions. |
| 12134041 |
Down-modulation of Sam68 expression caused exclusive nuclear retention and colocalization of both Rev and CRM1. | →View more information from publications. |
Recent Publications on XPO1: |  |
Nuclear export of the yeast hexokinase 2 protein requires the Xpo1 (Crm1)-dependent pathway.
Hexokinase 2 (Hxk2) from Saccharomyces cerevisiae was one of the first... | 15th October, 2009
| Department of Biochemistry and Molecular Biology, University of Oviedo,
| J Biol Chem. 2009 Jul 31;284(31):20548-55. Epub 2009 Jun 12.
DOI Direct Link |
Stimulated by retinoic acid gene 8 (STRA8) shuttles between nucleus and cytoplasm and displays transcriptional activity.
Stimulated by Retinoic Acid gene 8 (Stra8) encodes a protein crucial for... | 7th October, 2009
| University of Rome Tor Vergata, Italy;
| J Biol Chem. 2009 Oct 5.
DOI Direct Link |
Structural basis for leucine-rich nuclear export signal recognition by CRM1.
CRM1 (also known as XPO1 and exportin 1) mediates nuclear export of... | 19th June, 2009
| Department of Pharmacology, University of Texas Southwestern Medical
| Nature. 2009 Apr 30;458(7242):1136-41. Epub 2009 Apr 1.
DOI Direct Link |
Structural basis for assembly and disassembly of the CRM1 nuclear export complex.
CRM1 (or exportin 1, Xpo1) transports proteins out of the cell nucleus... | 30th May, 2009
| Department of Pharmacology, University of Texas Southwestern Medical
| Nat Struct Mol Biol. 2009 May;16(5):558-60. Epub 2009 Apr 1.
DOI Direct Link |
CRM1-mediated nuclear export of proteins and drug resistance in cancer.
Expression levels of intact tumor suppressor proteins and molecular... | 12th March, 2009
| Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa,
| Curr Med Chem. 2008;15(26):2648-55.
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→View more research publications. |
XPO1 results (if any) from reagent suppliers | 
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Rabbit anti-CRM1/XPO1 Antibody BL1956, affinity purified
CRM1 (Exportin 1) Antibody (BL1956). Affinity Purified. Anti-CRM-1 Antibody, Anti-XPO1 Antibody, Anti-. Exportin1 Antibody. Produced in Rabbit. Catalog No.
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http://www.natutec.de/pdf_bethyl/A300-490A.pdf...
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Ran antibody, Ran [ARAN1] Antibody, Mouse Monoclonal Antibody
Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export ... Found in a trimeric export complex with SNUPN, Ran and XPO1. ...
http://www.genwaybio.com/product_info.php?products_id=190802...
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CRM1 (H-300) Antibody sc-5595
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, XPO1, 7514, 2p15, NM_003400 · O14980
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http://www.scbt.com/datasheet-5595-crm1-h-300-antibody.html...
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DDX3X antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked ...
Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced ... Shuttles between the nucleus and the cytoplasm in a XPO1-dependent manner. ...
http://www.genwaybio.com/product_info.php?products_id=60209...
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Avian Influenza Nucleoprotein antibody (ab22285) | Abcam
It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide ...
http://www.abcam.com/Avian-Influenza-Nucleoprotein-antibody-...
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CHEK1 peptide, Chk1 (Ab-280) Antibody Blocking Peptide peptide
Subunit: Interacts with BRCA1, CLSPN, PPM1D, RAD51, TIMELESS, XPO1/CRM1 and YWHAZ/14-3-3 ... Note=Nuclear export is mediated at least in part by XPO1/CRM1.
...
http://www.genwaybio.com/product_info.php?products_id=213317...
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Cell Death Survey
RAD51, RAD51 homolog; XIAP, X-linked inhibitor of apoptosis; XPO1, exportin 1; XRCC,. X-ray repair complementing defective repair in Chinese hamster cells. ...
http://www.abgent.com/downloads/posters/necroptosis.pdf...
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