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XRCC1


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Gene DB Home
Symbol:XRCC1
Name(s):X-ray repair complementing defective repair in Chinese hamster cells 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:RCC
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17849423 Arg399Gln polymorphism is associated with increased frequency of p53 mutations in codon 249 among the Guangxi population of China.
18199464 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18214807 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18267032 Observational study of gene-disease association. (HuGE Navigator)
18272472 Observational study of gene-disease association. (HuGE Navigator)
18320070 Observational study of gene-disease association. (HuGE Navigator)
18330515 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18336890 Observational study of gene-disease association. (HuGE Navigator)
18347181 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18349297 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDpoly polymerase family, member 1X-ray repair cross complementing protein 1--Pubmed
HPRDAPEX nucleaseX-ray repair cross complementing protein 1--Pubmed
HPRDAPEX nucleaseX-ray repair cross complementing protein 1--Pubmed
HPRDbreast cancer 1, early onset isoform 1X-ray repair cross complementing protein 1--Pubmed
HPRDbreast cancer 1, early onset isoform 1X-ray repair cross complementing protein 1--Pubmed
HPRDligase III, DNA, ATP-dependent isoform alphaXRCC1--Pubmed
HPRDpolymerase, betaX-ray repair cross complementing protein 1--Pubmed
HPRDpolymerase, betaX-ray repair cross complementing protein 1--Pubmed
BINDX-ray repair cross complementing protein 1polynucleotide kinase 3'-phosphatasePhosphorylated XRCC1 interacts with PNK.-Pubmed
HPRDX-ray repair cross complementing protein 1nei endonuclease VIII-like 1--Pubmed

Recent Publications on XRCC1:

Pubmed Logo
Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population.
XRCC1 plays a central role in mammalian DNA repair processes. Two...
3rd November, 2009
Graduate Institute of Chinese Medical Science, China Medical University, Lupus. 2009 Oct 30.
DOI Direct Link
The Influence of Variations in the DNA Repair (XRCC1) Gene on HIV-1/AIDS among Indian Population.
Genetic polymorphisms in DNA repair genes may influence individual...
30th October, 2009
Department of Biotechnology, Panjab University, Chandigarh, India. Folia Biol (Praha). 2009;55(5):183-6.
Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial.
PURPOSE: Predicting efficacy and toxicity could potentially allow...
28th October, 2009
Oncology & Clinical Research and Pathology & Tumour Biology Sections, J Clin Oncol. 2009 Oct 26.
DOI Direct Link
Increase the cisplatin cytotoxicity and cisplatin-induced DNA damage in HepG2 cells by XRCC1 abrogation related mechanisms.
Cisplatin is one of the most potent chemotherapeutic anticancer drugs for...
27th October, 2009
Department of Occupational Health and Environmental Health, School of Toxicol Lett. 2009 Oct 21.
DOI Direct Link
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester...
24th October, 2009
Laboratory of Molecular Pharmacology, Center for Cancer Research, National EMBO J. 2009 Oct 22.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
DNA Changes as a Risk Factor for Barrett's Esophagus in Patients With Barrett's Esophagus, Gastroesophageal Reflux, or Gastrointestinal Bleeding

Patents:

Patents logo
US Patent No.Title
6479055 Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
6737241 Methods for screening for transdominant intracellular effector peptides and RNA molecules
6753158 Assays, agents, therapy and diagnosis relating to modulation of cellular DNA repair activity
6794137 Gene markers useful for detecting skin damage in response to ultraviolet radiation
6824783 Methods for inhibition of membrane fusion-associated events, including HIV transmission

View more patents.

XRCC1 results (if any) from reagent suppliers

Google CSE Logo
XRCC1 antibody [33-2-5] (ab1838) | Abcam
Mouse monoclonal [33-2-5] to XRCC1. XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and ...
http://www.abcam.com/xrcc1-antibody-33-2-5-ab1838.html...

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XRCC1 Antibody #2735
Confocal immunofluorescent analysis of HeLa cells using XRCC1 Antibody (green). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). ...
http://www.cellsignal.com/products/2735.html...

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Anti-XRCC1 Polyclonal Antibody
Polyclonal Antibody against XRCC1 for use in ELISA, Immunohistochemistry (Frozen ), Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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XRCC1 Antibody
protein 1 (XRCC1) is a DNA repair protein important in both ... XRCC1 Antibody ( green). Actin filaments have been labeled with ...
http://www.cellsignal.com/pdf/2735.pdf...

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Anti-XRCC1 Monoclonal Antibody
Monoclonal Antibody against XRCC1 for use in Immunohistochemistry (Paraffin)
http://www.bioreagents.com/products/productDetails/productDe...

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XRCC1 (D-18) Antibody sc-5902
See how others have used XRCC1 (D-18): sc-5902 antibody and or XRCC1 (D-18) ... XRCC1 interacts with the p58 subunit of DNA Pol alpha-primase and may ...
http://www.scbt.com/datasheet-5902-xrcc1-d-18-antibody.html...

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Phospho XRCC1 (S518/T519/T523) Antibody Bethyl Laboratories
Rabbit anti-Phospho XRCC1 (S518/T519/T523) Antibody, Affinity Purified.
http://www.bethyl.com/go/?product/A300-059A...

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