Monday November 23 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

XRCC4


Suggest Content
Advertise Here
Gene DB Home
Symbol:XRCC4
Name(s):X-ray repair complementing defective repair in Chinese hamster cells 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18165945 Haplotype analysis revealed an association of glioma risk with genetic variants in LIG4 block 1 (global P=0.011), and XRCC4 blocks 2 and 4 (both global P<0.0001).
18246529 Observational study of gene-disease association. (HuGE Navigator)
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
17901044 Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma.
17987338 Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.
11062157 Observational study of genotype prevalence. (HuGE Navigator)
12750264 Observational study of gene-disease association. (HuGE Navigator)
15680411 Observational study of gene-environment interaction. (HuGE Navigator)
15746160 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16485136 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDDNA ligase 4, ATP-dependentX-ray repair cross complementing protein 4 isoform 2--Pubmed
BINDDNA ligase IVX-ray repair cross complementing protein 4 isoform 1DNA Ligase IV (LIG4) interacts with XRCC4.-Pubmed
HPRDprotein kinase, DNA-activated, catalytic polypeptide isoform 1X-ray repair cross complementing protein 4 isoform 2--Pubmed
HPRDX-ray repair cross complementing protein 4 isoform 2AHNAK nucleoprotein isoform 2--Pubmed
HPRDX-ray repair cross complementing protein 4 isoform 2AHNAK nucleoprotein isoform 2--Pubmed

Recent Publications on XRCC4:

Pubmed Logo
Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.
The DNA ligase IV-Xrcc4 complex is responsible for the ligation of broken...
20th October, 2009
Centro de Investigaciones Biologicas (CIB), Consejo Superior de DNA Repair (Amst). 2009 Oct 15.
DOI Direct Link
Limiting the persistence of a chromosome break diminishes its mutagenic potential.
To characterize the repair pathways of chromosome double-strand breaks...
17th October, 2009
Department of Cancer Biology, Division of Radiation Biology, Beckman PLoS Genet. 2009 Oct;5(10):e1000683. Epub 2009 Oct 16.
DOI Direct Link
ARTEMIS nuclease facilitates apoptotic chromatin cleavage.
One hallmark of apoptosis is DNA degradation that first appears as high...
8th October, 2009
CNRS, Institut de Pharmacologie et de Biologie Structurale, Universite de Cancer Res. 2009 Oct 15;69(20):8120-6. Epub 2009 Oct 6.
DOI Direct Link
Mre11: roles in DNA repair beyond homologous recombination.
Myelodysplastic syndromes (MDS) are characterized by genetic instability...
17th September, 2009
Nat Struct Mol Biol. 2009 Aug;16(8):798-800.
DOI Direct Link
Role of mammalian Mre11 in classical and alternative nonhomologous end joining.
The mammalian Mre11-Rad50-Nbs1 (MRN) complex coordinates double-strand...
17th September, 2009
Department of Medicine, Harvard Medical School and Beth Israel Deaconess Nat Struct Mol Biol. 2009 Aug;16(8):814-8. Epub 2009 Jul 26.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6818401 Method of detection and interpretation of mutations through expression or function tests of haploid genes
6808887 Uses of Ku70
6753158 Assays, agents, therapy and diagnosis relating to modulation of cellular DNA repair activity

View more patents.

XRCC4 results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
XRCC4 antibodies. ... XRCC4 antibody - ChIP Grade. WB, ChIP. Images · Customer Abreviews: 4 stars (out of 5) · Specific publication references ...
http://www.abcam.com/index.html?t=191&pt=1&c=878...

Thumbshot
XRCC4 (4) Antibody sc-136124
mouse monoclonal IgG2b, 50 µg/0.5 ml; recommended for detection of XRCC4 of ... XRCC4 (4): sc-136124. Western blot analysis of XRCC4 expression in HeLa ...
http://www.scbt.com/datasheet-136124-xrcc4-4-antibody.html...

Thumbshot
XRCC4 antibody - ChIP Grade (ab145) | Abcam
Rabbit polyclonal to XRCC4 - ChIP Grade. Human XRCC4 gene restores DNA double- strand break repair and the ability to support V(D)J recombination of ...
http://www.abcam.com/XRCC4-antibody-ChIP-Grade-ab145.html...

Thumbshot
XRCC4 (H-233) Antibody sc-5606
rabbit polyclonal IgG, 200 µg/ml; epitope corresponding to amino acids 1-233 mapping at the N-terminus of XRCC4 of human origin; recommended for detection
...
http://www.scbt.com/datasheet-5606-xrcc4-h-233-antibody.html...

Thumbshot
Human DNA Ligase IV/XRCC4 Tetramer
system co-expressing recombinant human DNA Ligase IV and XRCC4. ... 0.1% Triton X-100] and serial dilutions of DNA Ligase IV/XRCC4 in a 20 µL reaction ...
http://www.rndsystems.com/pdf/4140-100-eb.pdf...

Thumbshot
XRCC Antibody / XRCC Antibodies
XRCC4 (4) Antibody, sc-136124, mouse IgG2b, N/A, WB, IP, IF, human ... XRCC4 (H- 18) Antibody, sc-5388, goat IgG, N-terminus (h), ELISA, human ...
http://www.scbt.com/table-xrcc.html...

Thumbshot
Antibodies to DNA Repair Proteins
X4128, Anti-XRCC4 antibody produced in rabbit, affinity isolated antibody ... mouse ... Xrcc4(108138) rat ... Xrcc4(309995), rodent, human, IHC, WB, pricing
...
https://www.sigmaaldrich.com/etc/controller/controller-page....

Thumbshot

Search Bioportfolio and other Life Science Sites for XRCC4, or search for XRCC4 on BioPortfolio's antibody search engine.
This page has been viewed 358 times
Recent Search Terms used to find this page:
xrcc4 mre11 interaction | XRCC4 Chip | x-ray repair XRCC4 | xrcc4 | xrcc4 | cell chip anti-radiation supplier | xrcc4 antibody | anti-XRCC4 and ChIP | ligase iv | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.