Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17904587 |
Although the different genotypes were not associated with the risk of bladder cancer, individuals not carrying the two tandem repeats allele had an increased risk of bladder cancer compared with those carrying the allele with two repeats. |
| 17901044 |
Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma. |
| 17389609 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17355791 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 17901044 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17904587 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18000863 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12750264 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15680411 |
Observational study of gene-environment interaction. (HuGE Navigator) |
| 15824172 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16137195 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17984099 |
These data suggest that Ku80 functions as a novel receptor for Tbeta4 and mediates its intracellular activity. |
| 17943968 |
HCT116 cells heterozygous for deficiency have high rates of chromosomal instability. |
| 17982634 |
Expression of Ku86 in breast cancer tissue and normal breast tissue with immunohistochemistry are largely equal. |
| 17507472 |
Results describe the effect of Ku80 on both provirus integration and the resulting transgene expression in cells transduced with retroviral vectors. |
| 17671430 |
potential relevance of Bin1-Ku interaction to cancer are discussed in light of these findings |
| 16014171 |
findings suggest Ku80 as a cellular factor targeted by Tax in engendering clastogenic DNA damage. |
| 12324457 |
role of expression in NF-kappaB activation and COX-2 expression |
| 17289874 |
low mRNA and protein expression in the BRCA1/BRCA2 and XRCC5 genes occur in lung adenocarcinoma and squamous cell carcinoma, respectively, and promoter hypermethylation is the predominant mechanism in deregulation of these genes |
| 14511439 |
frequency of flat or raised moles is associated with polymorphism at or near this DNA repair gene and certain alleles are associated with less efficient DNA repair and greater nevus density |
| 15910003 |
Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that human Ku80 and Orc2 bind to replication origins independently of each other, while Ku binding precedes that of Orc-3, -4, and -6. |
| 15123719 |
Results show that Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) modulate RAG-mediated cleavage during V(D)J recombination. |
| 12403924 |
The expression of Ku is upregulated in human neuroectodermal tumor cells by retroviral DNA integration |
| 16713581 |
Dimeric particles are observed in which two DNA-PKcs/Ku70/Ku80 holoenzymes interact through the N-terminal HEAT repeats. |
| 17214517 |
the gene encoding Ku86 (XRCC5) is an essential gene in human somatic cells, and its absence cannot be suppressed by the loss of p53 function |
| 11328876 |
A functional interaction of Ku with Werner exonuclease facilitates digestion of DNA containing 8-oxoadenine and 8-oxoguanine modifications. |
| 12518983 |
The mechanism that regulates for nuclear localization of Ku70 and Ku80 appears to play, at least in part, a key role in regulating the physiological function of Ku in vivo. |
| 17187679 |
poly(ADP-ribose)polymerase-1 and Ku70/Ku80 are transcriptional regulators of S100A9 gene expression |
| 17496833 |
These data support a new role for Ku in the migration of monocytes into tissues, which depends on a tightly regulated pathway of intracellular redistribution. |
| 12547193 |
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment |
| 15640154 |
Ku is involved in transcriptional recycling with androgen dependent promoters |
| 12391174 |
These results suggest that association of Ku with transcription sites is important for maintenance of global transcription levels. |
| 15613478 |
DNA degradation diminished the amount of Ku70 associated with gamma-H2AX but not that of nuclear DNA helicase II. |
| 12177300 |
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus |
| 12017286 |
Expression of Ku70/Ku80 proteins is decreased in malignant melanomas of the oral cavity. |
| 16448389 |
The present study suggests that Ku binds IRES -(internal ribosomal entry site)elements within RNA molecules, and that Ku plays a role in the modulation of IRES mediated mRNA translation. |
| 12867423 |
DNA repair proteins Ku70 and Ku80 expression is lost in cell nucleus after oxidative stress |
| 14617623 |
binding of the Ku complex at chromosomal breaks may be necessary to maintain the sliding clamps (PCNA) on chromatin |
| 15220460 |
DNA-binding component of human OF-1 (which binds Herpes simplex virus type 1 origin of replication) contains Ku70 and Ku80 proteins |
| 17124166 |
Functions in nonhomologous DNA end joining. |
| 15817152 |
Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm and for the nuclear translocation of Ku80 through its heterodimerization with Ku70. |
| 12467650 |
Transcripts of Ku70 and Ku86 genes were detected by RT-PCR and Ku protein was localized in the nucleus of neutrophils as a heterodimer |
| 15824061 |
Ku70/80 interacts directly with the RNA component of human telomerase, independent of the human telomerase reverse transcriptase protein. |
| 17159921 |
The three-dimensional structure of the human full-length Ku70-Ku80 dimer at 25 A resolution, alone and in complex with DNA, by using single-particle electron microscopy was reconstructed. |
| 17534116 |
The expression and subcellular localization of Ku80 in the nucleus demonstrated the involvement of this protein in the photo-oxidative cell death pathway. |
| 12377759 |
Ku associates with hTERT, and this interaction may function to regulate the access of telomerase to telomeric DNA ends |
| 12077346 |
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. |
| 11985783 |
Ku80 alteration is unlikely to be involved in multiple myeloma |
| 16537541 |
The pre-steady state binding of Ku with various DNA duplex substrates was studied and a redox-sensitive Ku-DNA interaction was identified. |
| 11937624 |
transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element |
