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YES1


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Symbol:YES1
Name(s):v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:HsT441, P61-YES, Yes, c-yes
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18328427 Binding of CD95 Ligand to CD95 on glioblastoma cells recruit Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases.
17692281 Thus, these results suggest that endogenous c-Src, c-Yes, and Lyn are differentially activated through Cdc2 activation during M phase.
17898870 c-Yes induction results in increased colorectal carcinoma cell motility but did not promote proliferation. In later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread & metastasis rather than tumor growth.
17109515 The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer.
12456296 This review summarizes the potential functions of c-Yes and its ability to modulate signals that are distinct from c-Src.
15039424 Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95
16289864 c-Yes 3'-UTR contains at least three newly identified adenine/uridine-rich elements (AREs) which are bound specifically by ARE-binding proteins HuR and AUF1.
15148312 activation of c-Yes is important for maintaining embryonic stem cells in an undifferentiated state
17143518 Nucleus-located c-Yes may be a useful marker to detect early-stage hepatocellular carcinoma.
12080032 cAMP activates while Ca(2+) inhibits human sperm c-yes kinase activity

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD36viral oncogene yes-1 homolog 1--Pubmed
HPRDColony stimulating factor 1 receptorviral oncogene yes-1 homolog 1--Pubmed
HPRDcolony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral oncogene homologc-Yes--Pubmed
HPRDSynapse associated protein 90viral oncogene yes-1 homolog 1--Pubmed
HPRDpostsynaptic density protein 95c-Yes--Pubmed
HPRDJanus kinase 2viral oncogene yes-1 homolog 1--Pubmed
HPRDJanus kinase 2c-Yes--Pubmed
HPRDCD46viral oncogene yes-1 homolog 1--Pubmed
HPRDCD46 antigen, complement regulatory protein isoform 1 precursorc-Yes--Pubmed
HPRDnephrin precursorviral oncogene yes-1 homolog 1--Pubmed

Recent Publications on YES1:

Pubmed Logo
Coexpression network based on natural variation in human gene expression reveals gene interactions and functions.
Genes interact in networks to orchestrate cellular processes. Analysis of...
3rd October, 2009
Medical Scientist Training Program, University of Pennsylvania, Genome Res. 2009 Nov;19(11):1953-1962. Epub 2009 Oct 1.
DOI Direct Link
Caveolin-1-dependent and -independent membrane domains.
Lipid rafts defined as cholesterol- and sphingomyelin-rich domains have...
2nd September, 2009
Centre de Recherche des Cordeliers, INSERM, U872, Universite Pierre et J Lipid Res. 2009 Aug;50(8):1609-20. Epub 2008 Dec 12.
DOI Direct Link
Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.
Protein tyrosine phosphatase-alpha (PTPalpha) is a widely expressed...
18th August, 2009
Department of Pathology and Laboratory Medicine, University of British Am J Physiol Cell Physiol. 2009 Jul;297(1):C133-9. Epub 2009 May 6.
DOI Direct Link
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration.
In the central nervous system, collapsin response mediator protein 2...
22nd July, 2009
Department of Neurooncology and Neuroinflammation, INSERM, U842, J Biol Chem. 2009 May 8;284(19):13265-76. Epub 2009 Mar 10.
DOI Direct Link
Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells.
Hepatocyte growth factor (HGF)/Met system is deregulated in tumors and is...
27th June, 2009
Dipartimento di Morfologia Umana e Scienze Biomediche 'Citta Studi', Carcinogenesis. 2009 Jun;30(6):937-45. Epub 2009 Apr 8.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Treatment of Melasma With Stabilized Kligman Preparation Associated or Not With Pulsed Dye Laser

Patents:

Patents logo
US Patent No.Title
7589070 Surface modification for improving biocompatibility
7021838 Optimizing alignment of an optical fiber to an optical output port
6989232 Proteins and nucleic acids encoding same
6948174 IMS MFS (message format service) metamodel
6753314 Protein-protein complexes and methods of using same

View more patents.

YES1 results (if any) from reagent suppliers

Google CSE Logo
Yes1 antibody (ab61206) | Abcam
Mouse monoclonal to Yes1. The gene that codifies for Yes1 is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has
tyrosine ...
http://www.abcam.com/Yes1-antibody-ab61206.html...

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Phospho-YES1-Y537/Phospho-SRC-Y530 Antibody
(TOP)Dot blot analysis of anti-Phospho-YES1-Y537/Phospho-SRC-Y530 Antibody (Cat. #AP3254a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non ...
http://www.abgent.com/products/catalog_no/AP3254a_Phospho_YE...

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Yes1 (phospho Y537) antibody (ab60028) | Abcam
Rabbit polyclonal to Yes1 (phospho Y537). The gene that codifies for Yes1 is the cellular homolog of the Yamaguchi sarcoma virus oncogene.
http://www.abcam.com/Yes1-phospho-Y537-antibody-ab60028.html...

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c-Src (B-12) Antibody sc-8056
Human, YES1, 7525, 18p11.32, NM_005433 · P07947 · 164880. Mouse, Fgr, 14191, 4 D2.3, P14234 ... Mouse, Yes1, 22612, 5 B1, Q04736, N/A. Ordering Information ...
http://www.scbt.com/datasheet-8056-c-src-b-12-antibody.html...

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Yes1 antibodies: Signal Transduction > Protein Phosphorylation ...
Yes1 antibodies. ... Image Abreview Publication. ab60028 · Yes1 (phospho Y537) antibody. IHC-P, WB, ELISA. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=86833&pt=1&c=2117&ei=&mu=r...

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c-Yes (F-7) Antibody sc-8403
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, YES1, 7525, 18p11.32, NM_005433 ...
http://www.scbt.com/datasheet-8403-c-yes-f-7-antibody.html...

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Abgent - Phosphospecific Antibody
AP3254aNEW, Phospho-YES1-Y537/Phospho-SRC-Y530 Antibody, WB, IHC, DB, E, H ..... BP3254a, Phospho-YES1-Y537 Antibody Blocking Peptide ...
http://www.abgent.com/products/category/phosphospecific...

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