Wednesday November 25 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

YWHAB


Suggest Content
Advertise Here
Gene DB Home
Symbol:YWHAB
Name(s):tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Type:protein-coding
Organism:Homo sapiens
Synonyms:GW128, HS1, KCIP-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17717073 Ror2 induces osteogenic differentiation, at least in part, through a release of the 14-3-3beta-mediated inhibition
17531190 PBF is a new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth
15022330 HS1 with EPEP insertion polymorphism transmits accelerated signals from B cell receptor and is involved in pathogenesis of systemic lupus erythematosus.
15389601 novel binding site on 14-3-3 for integrin beta1 and a functional amphipathic groove, rather than its interaction with integrin beta1, is required for 14-3-3 regulation of cell spreading and migration.
12669242 Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy.
12618428 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
12482592 14-3-3 binds to the IGF-1 receptor after IGF1R's serine autophosphorylation
12468542 14-3-3 beta interacts with the TSC1-TSC2 complex and negatively regulates the function of the TSC proteins
12364343 TSC2 associates with 14-3-3 in vivo
12582162 MK2 phosphorylates TSC2, which creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBCL2 antagonist of cell deathtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide--Pubmed
HPRDBCL2-antagonist of cell death protein14-3-3 Beta--Pubmed
HPRDBH3 interacting domain death agonist isoform 214-3-3 Beta--Pubmed
HPRDB-Raftyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide--Pubmed
HPRDv-raf murine sarcoma viral oncogene homolog B114-3-3 Beta--Pubmed
BINDv-raf murine sarcoma viral oncogene homolog B1-BRAF (B-Raf) interacts with an unspecified isoform of YWHAB (14-3-3-beta).-Pubmed
BINDv-raf murine sarcoma viral oncogene homolog B1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideB-RAF interacts with 14-3-3-beta.-Pubmed
BINDCas-Br-M ecotropic retroviral transforming sequencetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptidec-Cbl interacts with 14-3-3-beta.-Pubmed
BINDHuman protein kinase PITSLRE alpha 2-1 mRNA, and translated productstyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideCDK11-p110 interacts with 14-3-3-beta.-Pubmed
BIND-tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide14-3-3-beta interacts with cdc25A.-Pubmed

Recent Publications on YWHAB:

Pubmed Logo
Focal amplifications are associated with high-grade and recurrences in stage Ta bladder carcinoma.
Urinary bladder cancer is a heterogeneous disease, with tumors ranging...
13th October, 2009
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala Int J Cancer. 2009 Oct 9.
DOI Direct Link
Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.
Inappropriate activation of phosphatidylinositol 3-kinase-Akt signaling...
17th December, 2008
Department of Urology, Case Western Reserve University, Cleveland, OH Carcinogenesis. 2008 Nov;29(11):2210-7. Epub 2008 Aug 25.
DOI Direct Link
A novel regulatory mechanism of myosin light chain phosphorylation via binding of 14-3-3 to myosin phosphatase.
Myosin II phosphorylation-dependent cell motile events are regulated by...
11th November, 2008
Department of Physiology, University of Massachusetts Medical School, Mol Biol Cell. 2008 Mar;19(3):1062-71. Epub 2007 Dec 19.
DOI Direct Link
Normalization of 14-3-3 in CJD.
We report on a 47-year-old woman with autopsy proven Creutzfeldt-Jakob...
22nd October, 2008
Department of Neurology, University of Leuven, Belgium. Acta Neurol Belg. 2008 Jun;108(2):64-6.
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Previously, we identified 14-3-3 beta and zeta isoforms and proteolytic...
20th September, 2008
Department of Neurosurgery, University of Pennsylvania School of Medicine, Brain Res. 2008 Jun 5;1213:1-11. Epub 2008 Apr 1.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7229774 Expression profile of prostate cancer

View more patents.

YWHAB results (if any) from reagent suppliers

Google CSE Logo
YWHAB (14-3-3 protein beta/alpha) Antibody (C-term)
#AP8155b) is used in Western blot to detect YWHAB in Jurkat cell lysate. YWHAB ( 14-3-3 protein beta/alpha) Antibody (C- ...
http://www.abgent.com/products/catalog_no/AP8155b_YWHAB_14_3...

Thumbshot
pan-14-3-3 (FL-246) Antibody sc-13959
Human, YWHAB, 7529, 20q13.12, NM_003404, NM_139323 · P31946 · 601289. Mouse, Ywhab, 54401, 2 H3, Q9CQV8, N/A. Mouse, Ywhab, 54401, 2 H3, Q9CQV8 ...
http://www.scbt.com/datasheet-13959-14-3-3-beta-fl-246-antib...

Thumbshot
Antibody Products - IgG Polyclonal Antibodies - GenWay
YWHAB; GW128, HS1, KCIP-1 - Protein kinase C inhibitor protein 1; KCIP-1; Protein 1054; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=Y...

Thumbshot
pan 14-3-3 (K-19) Antibody sc-629
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, YWHAB, 7529, 20q13.12, P31946 ...
http://www.scbt.com/datasheet-629-pan-14-3-3-k-19-antibody.h...

Thumbshot
P27KIP1 antibody, p27Kip1 (Ab-10) Antibody Antibody, Rabbit ...
p27Kip1 (Ab-10) Antibody interacts with YWHAB, IgG (GenWay Catalog #: 18-785- 210327). p27Kip1 (Ab-10) Antibody interacts with 14-3-3 beta + zeta [22-IID8B],
...
http://www.genwaybio.com/product_info.php?products_id=210327...

Thumbshot
Protein phosphorylation is one of the most significant signal ...
YWHAB. BMX. CHK. DLK. FAK2. GSK3A. KIS. MEKK4. NEK8. PDGFRA. PIP5K1A. PTK6. STK33. YWHAZ. BRAF. CHK1. DMPK. FASTK. GSK3B. KIST. MEKK4. NIK. PDGFRB. PIP5K1B
...
http://www.abgent.com/downloads/Kinases.pdf...

Thumbshot
KIF5B antibody, KIF5B (kinesin family member 5B) Antibody, Rabbit ...
KIF5B (kinesin family member 5B) interacts with YWHAB, IgG (GenWay Catalog #: 18 -003-42455). KIF5B (kinesin family member 5B) interacts with 14-3-3 beta + ...
http://www.genwaybio.com/product_info.php?products_id=42455...

Thumbshot

Search Bioportfolio and other Life Science Sites for YWHAB, or search for YWHAB on BioPortfolio's antibody search engine.
This page has been viewed 368 times
Recent Search Terms used to find this page:
antibody binding site tryptophan tyrosine | tyrosine 3-monooxygenase tryptophan 5-monooxygenase activation protein beta polypeptide 2 | 14-3-3 protein and cancer | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein | naming polypeptides tryptophan | tyrosine 3-monooxygenase 14-3-3 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein | Tyrosine 3-Monooxygenase patent | TYROSINE 3-MONOOXYGENASE/TRYPTOPHAN 5-MONOOXYGENASE ACTIVATION PROTEIN | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.