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YWHAE
| Symbol: | YWHAE | | Name(s): | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | 14-3-3E, FLJ45465, KCIP-1, MDCR, MDS | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15838597 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17728103 |
These results suggest that 14-3-3epsilon bound to MK5 inhibits cell migration by inhibiting the phosphorylation of HSP27 whose phosphorylation regulates F-actin polymerization, actin cytoskeleton organization and subsequent actinfilament dynamics. |
| 14966136 |
14-3-3 adapter proteins may have a role in regulating CD81 signaling, possibly dependent on cellular redox |
| 16679322 |
plasma membrane Na+/Ca2+ exchangers have inhibitory interactions with the 14-3-3 proteins |
| 16923798 |
Upon co-expression with 14-3-3epsilon, mutant HERG channels still bound 14-3-3epsilon but did not respond with a hyperpolarizing shift in voltage dependence as seen in wild-type channels. |
| 11782387 |
Identification of frequent G(2) checkpoint impairment and a homozygous deletion of 14-3-3epsilon at 17p13.3 in small cell lung cancers. |
| 15838597 |
14-3-3 epsilon is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide. |
| 12657644 |
study suggests that the cleavage of 14-3-3 protein during apoptosis promotes cell death by releasing the associated Bad protein from the 14-3-3 protein and facilitates Bad translocation to the mitochondria and its interaction with Bcl-x(L) |
| 17278997 |
These results indicate that the epsilon isoform of 14-3-3 is a component of PrP amyloid deposits of GSS and suggest that this is the sole 14-3-3 isoform specifically involved in the neuropathologic changes associated with this disorder. |
| 12917326 |
HSF1 binding to 14-3-3 epsilon requires HSF1 phosphorylation on serines 303 and 307, the serine phosphorylation-dependent binding of HSF1 to 14-3-3 epsilon results in the transcriptional repression of HSF1 and its sequestration in the cytoplasm. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| BIND | Homo sapiens chromosome 11, reference assembly. | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | The cIAP-2 promoter interacts with 14-3-3-epsilon. | - | Pubmed |
| HPRD | BCL2 antagonist of cell death | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | - | - | Pubmed |
| HPRD | BCL2-antagonist of cell death protein | 14-3-3 epsilon | - | - | Pubmed |
| HPRD | Calmodulin 1 | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | - | - | Pubmed |
| HPRD | calmodulin 1 | 14-3-3 epsilon | - | - | Pubmed |
| BIND | Human protein kinase PITSLRE alpha 2-1 mRNA, and translated products | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | CDK11-p110 interacts with 14-3-3-epsilon. | - | Pubmed |
| BIND | - | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | 14-3-3-epsilon interacts with cdc25A. | - | Pubmed |
| HPRD | cell division cycle 25A | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | - | - | Pubmed |
| HPRD | cell division cycle 25A | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | - | - | Pubmed |
| HPRD | cell division cycle 25A isoform a | tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide | - | - | Pubmed |
YWHAE results (if any) from reagent suppliers | 
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YWHAE protein, 14-3-3 Epsilon Human recombinant protein
Buy quality YWHAE protein (e. coli), YWHAE, 14-3-3 Epsilon Human recombinant protein, (n/an/a). YWHAE, MDS, MDCR, KCIP-1, 14-3-3E, 14-3-3 Epsilon, ...
http://www.genwaybio.com/product_info.php?products_id=46044...
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Phospho-14-3-3-S58 Antibody
#AP3000a) is used in Western blot to detect YWHAE in mouse brain (left) and HL60 (right) tissue lysates. Phospho-14-3-3-S58 Antibody ...
http://www.abgent.com/products/catalog_no/AP3000a...
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Purified Anti-14-3-3 Epsilon Antibody - BioLegend
Other Names: 14-3-3E, YWHAE < YWHAE>. Structure: 14-3-3 protein superfamily, homodimer, 29 kD. Distribution: Cytoplasm. Function: Adapter protein implicated
...
http://www.biolegend.com/purified-anti-14-3-3-epsilon-antibo...
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14-3-3 β/ε/ζ (3C8) Antibody sc-59420
Mouse, Ywhae, 22627, 11 B5, P62259, N/A. Mouse, Ywhaz, 22631, 15 B3.1, P63101, N /A. Mouse, Ywhab, 54401, 2 H3, Q9CQV8 ...
http://www.scbt.com/datasheet-59420-14-3-3-beta-epsilon-zeta...
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Phospho-14-3-3-T232 Antibody
14-3-3 protein epsilon; 14-3-3E; YWHAE;. Application Data: Calculated MW: 29174 Da. Phospho-14-3-3-T232 Antibody. (Top)The anti-YWHAZ Pab (Cat. ...
http://www.abgent.com/products/catalog_no/AP3001a_Phospho_14...
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14-3-3 ε (E-20) Antibody sc-31962
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, YWHAE, 7531, 17p13.3, NM_006761 ...
http://www.scbt.com/datasheet-31962-14-3-3-epsilon-a-14-anti...
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14-3-3 beta + zeta antibody, 14-3-3 beta + zeta [22-IID8B ...
Subunit: Homodimer, and heterodimer with YWHAG, YWHAE and YWHAQ. Interacts with SSH1 and TORC2/CRTC2. Subcellular Location: Cytoplasm. Melanosome. ...
http://www.genwaybio.com/product_info.php?products_id=190773...
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