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YWHAG


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Symbol:YWHAG
Name(s):tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Type:protein-coding
Organism:Homo sapiens
Synonyms:14-3-3GAMMA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17284169 Both single marker and haplotype analyses were negative for the Ywhag gene association with smoking initiation and nicotine dependence.
17611984 Detection of only 2 (14-3-3 eta and gamma) out of 7 different isoforms in synovial fluid suggests they are specific to the site of joint inflammation
17394238 our data indicate that 14-3-3gamma may contribute to tumorigenesis by promoting genomic instability.
17109079 Interaction of human 14-3-3gamma with the small heat shock protein Hsp20 was analyzed by means of size-exclusion chromatography and chemical crosslinking.
15057270 14-3-3 suppresses importin alpha/beta-dependent nuclear localization of Thr157-phosphorylated p27, suggesting implications for cell cycle disorder in Akt-activated cancer cells.
12482592 14-3-3 binds to the IGF-1 receptor after IGF1R's serine autophosphorylation
12364343 TSC2 associates with 14-3-3 in vivo
11996670 Results show that three 14-3-3 isoforms, beta, gamma and eta, are DAL-1/Protein 4.1B-binding proteins.
16223726 multiple interactions of AICD with FE65 and 14-3-3gamma modulate FE65-dependent gene transactivation
11824616 Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21).

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit precursortyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
HPRDcalpain 3 isoform atyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
BINDHuman protein kinase PITSLRE alpha 2-1 mRNA, and translated productstyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideCDK11-p110 interacts with 14-3-3-gamma.-Pubmed
HPRDCDC-like kinase 2 isoform hclk2tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
HPRDCDC-like kinase 3 isoform hclk3tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
HPRDCSE1 chromosome segregation 1-like proteintyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
HPRDDNA fragmentation factor, 45kDa, alpha polypeptide isoform 1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
HPRDdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
HPRDeukaryotic translation elongation factor 1 gammatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed
HPRDFKHRtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide--Pubmed

Recent Publications on YWHAG:

Pubmed Logo
14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies.
The hypothalamic-neurohypophyseal system (HNS) mediates neuroendocrine...
26th February, 2008
Henry Wellcome Laboratories for Integrative Neuroscience and J Neuroendocrinol. 2007 Nov;19(11):913-22.
DOI Direct Link
RhoA, encoding a Rho GTPase, is associated with smoking initiation.
We used microarray analysis of acute nicotine responses in mouse brain to...
30th January, 2008
Virginia Institute for Psychiatric and Behavioral Genetics and Department Genes Brain Behav. 2007 Nov;6(8):689-97. Epub 2006 Dec 20.
DOI Direct Link
A proteomic analysis during serial subculture and osteogenic differentiation of human mesenchymal stem cell.
Although previous studies have reported the effects of extensive...
9th December, 2006
Brain Korea 21 Project for Medical Science, Yonsei University College of J Orthop Res. 2006 Nov;24(11):2059-71.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods

YWHAG results (if any) from reagent suppliers

Google CSE Logo
Z3402 14-3-3 Zeta, histidine-tagged human recombinant, expressed ...
WH0007532M2, Monoclonal Anti-YWHAG antibody produced in mouse. T5942, Monoclonal Anti-14-3-3 θ/τ antibody produced in mouse ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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14-3-3 γ (C-16) Antibody sc-731
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, YWHAG, 7532, 7q11.23, NM_012479 ...
http://www.scbt.com/datasheet-731-14-3-3-gamma-c-16-antibody...

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E1408 14-3-3 Eta histidine-tagged human recombinant, expressed in ...
T0953, 14-3-3 Tau/Theta histidine-tagged human. Z3402, 14-3-3 Zeta, histidine- tagged human. WH0007532M2, Monoclonal Anti-YWHAG antibody produced in mouse ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=E140...

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pan 14-3-3 (K-19) Antibody sc-629
Mouse, Ywhag, 22628, 5 G2, P61982, N/A. Mouse, Ywhah, 22629, 5 B1, P68510, N/A. Mouse, Ywhaq, 22630, 12 A1.3, P68254 ...
http://www.scbt.com/datasheet-629-pan-14-3-3-k-19-antibody.h...

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14-3-3 beta + zeta antibody, 14-3-3 beta + zeta [22-IID8B ...
Subunit: Homodimer, and heterodimer with YWHAG, YWHAE and YWHAQ. Interacts with SSH1 and TORC2/CRTC2. Subcellular Location: Cytoplasm. Melanosome. ...
http://www.genwaybio.com/product_info.php?products_id=190773...

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Antibodies to 14-3-3, gamma
... Protein kinase C inhibitor protein 1, KCIP-1, Tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein, gamma polypeptide, YWHAG ...
http://www.usbio.net/displayPage.php?ProdSku=0014-07...

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YWHAE protein, 14-3-3 Epsilon Human recombinant protein
Homodimer, and heterodimer with YWHAB, YWHAG and YWHAQ. Interacts with HCV core protein. Subcellular Location: Cytoplasm (By similarity). Melanosome. ...
http://www.genwaybio.com/product_info.php?products_id=46044...

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