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YWHAZ


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Symbol:YWHAZ
Name(s):tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Type:protein-coding
Organism:Homo sapiens
Synonyms:KCIP-1, MGC111427, MGC126532, MGC138156
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18290843 14-3-3 zeta protein and butyrylcholinesterase (BCHE) synergistic effects between polymorphisms in tau phosphorylation relate-genes may help in determining the risk profile for AD.
18290843 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18319590 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17704798 Knockdown of 14-3-3 zeta induces at least two isoform-specific phenotypes that are consistent with potential oncogenic activity during tumorigenesis.
18162532 14-3-3zeta has a critical role in anoikis suppression in lung cancer cells
17764575 findings suggest that over-expression of 14-3-3zeta is an early event in oral tumorigenesis and may have an important role in its development and progression
17918986 14-3-3zeta is a granule protein related to atherosclerosis
11956222 Identification of 14-3-3zeta as a protein kinase B/Akt substrate.
12589811 role for the 14-3-3zeta/ADAM 22 association in the regulation of cell adhesion and related signaling events
12323073 binds cofilin and LIM-domain-containing protein kinase 1

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAralkylamine N-acetyltransferasetyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide--Pubmed
HPRDarylalkylamine N-acetyltransferase14-3-3 zeta--Pubmed
BINDarylalkylamine N-acetyltransferasetyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptideAANAT interacts with 14-3-3-zeta isoform. This interaction was modeled on a demonstrated interaction between sheep AANAT and human 14-3-3-zeta.-Pubmed
HPRDAlpha 2A adrenergic receptortyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide--Pubmed
HPRDalpha-2A-adrenergic receptor14-3-3 zeta--Pubmed
HPRDAlpha 2B adrenergic receptortyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide--Pubmed
HPRDalpha-2B-adrenergic receptor14-3-3 zeta--Pubmed
HPRDAlpha 2C adrenergic receptortyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide--Pubmed
HPRDalpha-2C-adrenergic receptor14-3-3 zeta--Pubmed
HPRDAKT1tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide--Pubmed

Recent Publications on YWHAZ:

Pubmed Logo
Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function.
Parkin is an ubiquitin-protein ligase (E3), mutations of which cause...
3rd September, 2009
Section of Ophthalmology and Neuroscience, Leeds Institute for Molecular Proteomics. 2009 Sep;9(18):4284-97.
DOI Direct Link
Quantitative evaluation and selection of reference genes in a rat model of extended liver resection.
Partial hepatectomy (PHx) is a frequently used experimental model for the...
11th August, 2009
Department of General, Visceral and Transplantation Surgery, University J Biomol Tech. 2009 Apr;20(2):109-15.
Validation of housekeeping genes for quantitative real-time PCR in in-vivo and in-vitro models of cerebral ischaemia.
BACKGROUND: Studies of gene expression in experimental cerebral ischaemia...
28th July, 2009
Servei de Neurologia, Fundacio Privada Institut d'Investigacio Biomedica BMC Mol Biol. 2009 Jun 16;10:57.
DOI Direct Link
Reference genes for QRT-PCR tested under various stress conditions in Folsomia candida and Orchesella cincta (Insecta, Collembola).
BACKGROUND: Genomic studies measuring transcriptional responses to...
28th July, 2009
Institute of Ecological Science, VU University Amsterdam, De Boelelaan BMC Mol Biol. 2009 Jun 1;10:54.
DOI Direct Link
Copy number gain and oncogenic activity of YWHAZ/14-3-3zeta in head and neck squamous cell carcinoma.
Gene amplification, a common mechanism for oncogene activation in cancers,...
23rd July, 2009
Department of Molecular Virology, Immunology and Medical Genetics, The Int J Cancer. 2009 Aug 1;125(3):603-11.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7235358 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

YWHAZ results (if any) from reagent suppliers

Google CSE Logo
YWHAZ protein, 14-3-3 protein zeta/delta recombinant protein
Buy quality YWHAZ protein (e coli), YWHAZ, 14-3-3 protein zeta/delta recombinant protein, (ms sds elisa western blot). Protein kinase C inhibitor protein 1; ...
http://www.genwaybio.com/product_info.php?products_id=5234...

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Phospho-14-3-3-T232 Antibody
#AP3001a) is used in Western blot to detect YWHAZ in HL60 (left) and mouse brain (right) tissue lysates. (Buttom) Dot blot analysis of anti-14-3-3-pT232 Pab ...
http://www.abgent.com/products/catalog_no/AP3001a_Phospho_14...

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14-3-3 ζ (C-16) Antibody sc-1019
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, YWHAZ, 7534, 8q22.3, NM_003406, ...
http://www.scbt.com/datasheet-1019-14-3-3-zeta-c-16-antibody...

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MM tds template
YWHAZ primer mix 750 µl One tube of primer mix 8.33 µM. (plain cap). YWHAZ probe ... Each 50 µl reaction requires the addition of 3 µl of YWHAZ ...
http://www.eurogentec.com/uploads/RT-CKYD-YWHAZ.pdf...

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14-3-3 β/ε/ζ (3C8) Antibody sc-59420
Human, YWHAZ, 7534, 8q22.3, NM_003406, NM_145690 · P63104 · 601288. Mouse, Ywhae , 22627, 11 B5, P62259, N/A. Mouse, Ywhaz, 22631, 15 B3.1, P63101 ...
http://www.scbt.com/datasheet-59420-14-3-3-beta-epsilon-zeta...

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Purified Anti-14-3-3 Zeta/delta Antibody - BioLegend
... Protein kinase C inhibitor protein-1, Phospholipase A2, Tyrosine 3- monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (
YWHAZ) ...
http://www.biolegend.com/purified-anti-14-3-3-zeta-delta-ant...

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14-3-3 protein zeta/delta Antibody (T232)
14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1; YWHAZ. Application Data: Calculated MW: 27745 Da ...
http://www.abgent.com/products/catalog_no/AP8152d_14_3_3_pro...

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