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ZAP70
| Symbol: | ZAP70 | | Name(s): | zeta-chain (TCR) associated protein kinase 70kDa | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18022252 |
in Jurkat cells, ZAP-70 phosphorylation level increased under acidic environments; results suggest that extracellular low pH stimulates or enhances TCR signaling via ZAP-70 and p38 |
| 18190465 |
presents three CLL patients with discordant ZAP80 levels |
| 18322442 |
Regardless of CD38 expression level, CD38 and ZAP-70 expressions were significantly associated in B-CLL |
| 17767948 |
The point mutation found in Zap70 was causative for the DeltaT3 phenotype of primary celluluar immunodefiencies, including increased IgE plasma levels, a phenotype that has not been associated with altered Zap70 function in the past. |
| 17492476 |
LAT, ZAP-70, and DNMT1 protein levels in CD4(+) T cells can be associated with systemic lupus erythematosus. |
| 17931624 |
Results suggest that Zap-70 expression may be a better indicator of the mutational status of IgVH and prognosis of chronic lymphocytic leukemia than CD38 expression. |
| 18025306 |
Immune synapse formation requires ZAP70 recruitment by ezrin and CD43 removal by moesin. |
| 17577788 |
ZAP-70 expression over time in B chronic lymphocytic leukaemia. |
| 17785822 |
Zap70 signaling plays an important role in dexamethasone receptor-mediated transactivation of T lymphocytes. |
| 17534928 |
Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemia was performed. | →View more information from publications. |
Recent Publications on ZAP70: |  |
Mechanism of tumor cell-induced T-cell apoptosis mediated by galectin-1.
Galectin-1 (Gal-1) has been implicated in tumor progression partly via the... | 31st October, 2009
| Institute of Genetics, Biological Research Center, Hungarian Academy of
| Immunol Lett. 2009 Oct 26.
DOI Direct Link |
p53 expression by immunohistochemistry is an important determinant of survival in patients with chronic lymphocytic leukemia receiving frontline chemo-immunotherapy.
Although chromosome 17p abnormalities and TP53 mutations have been... | 30th October, 2009
| Department of Hematopathology.
| Leuk Lymphoma. 2009 Oct;50(10):1597-605.
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Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
RhoH is a hematopoietic-specific, GTPase-deficient member of the Rho... | 23rd October, 2009
| [1] Division of Experimental Hematology, Cincinnati Children's Hospital
| Leukemia. 2009 Oct 22.
DOI Direct Link |
Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance.
B-cell chronic lymphocytic leukemia (CLL), the most frequent leukemia in... | 23rd October, 2009
| Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento
| J Transl Med. 2009 Aug 28;7:76.
DOI Direct Link |
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.
ZAP-70 is critical for T cell receptor (TCR) signaling. Tyrosine to... | 21st October, 2009
| Department of Medicine, Rosalind Russell Medical Research Center for
| J Exp Med. 2009 Oct 26;206(11):2527-41. Epub 2009 Oct 19.
DOI Direct Link |
→View more research publications. |
ZAP70 results (if any) from reagent suppliers | 
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ZAP-70 Antibody / ZAP-70 Antibodies
ZAP-70 Antibody / ZAP-70 Antibodies. ... ZAP-70 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-zap-70.html...
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The Abcam catalog
ZAP70 antibodies. ... ZAP70 (phospho Y292) antibody [EPR1073]. Flow Cyt, ICC, WB .... ZAP70 antibody [SBZAP] (Alkaline Phosphatase). Flow Cyt, ELISA ...
http://www.abcam.com/index.html?t=71973&pt=1&c=612...
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Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody #2701
Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody detects endogenous levels of Zap- 70 only when phosphorylated at Tyr319. It cross-reacts with endogenous levels
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http://www.cellsignal.com/products/2701.html...
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ZAP70 antibody, prediluted (ab31009) | Abcam
Rabbit polyclonal to ZAP70, prediluted. ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and ...
http://www.abcam.com/ZAP70-antibody-prediluted-ab31009.html...
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p-ZAP-70 (Tyr 292) Antibody sc-12945
See how others have used p-ZAP-70 (Tyr 292): sc-12945 antibody and or p-ZAP-70 ( Tyr ... p-ZAP-70 (Tyr 292)-R: sc-12945-R. Western blot analysis of ZAP-70 ...
http://www.scbt.com/datasheet-12945-p-zap-70-tyr-292-antibod...
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ZAP70 antibody (ab13957) | Abcam
ZAP70, a 70 kDa member of the Syk tyrosine kinase family, ... See below for ZAP70 antibody images, references, products related to ab13957 and other tools.
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http://www.abcam.com/ZAP70-antibody-ab13957.html...
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ZAP-70 (M-20) Antibody sc-1526
See how others have used ZAP-70 (M-20): sc-1526 antibody and or ZAP-70 (M-20) antibody ... The Polycomb-group protein ENX-2 interacts with ZAP-70. Immunol.
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http://www.scbt.com/datasheet-1526-zap-70-m-20-antibody.html...
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