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CA1


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Gene DB Home
Symbol:CA1
Name(s):carbonic anhydrase I
Type:protein-coding
Organism:Homo sapiens
Synonyms:Car1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17464559 Decreased levels of carbonic anhydrase 1 isozyme is associated with type II diabetes.
15836783 cytosolic CA I, II, and XIII are downregulated in neoplastic colorectal mucosa compared to normal colorectal mucosa
16870440 X-ray crystallographic structure for the adduct of an activator with hCA I. Binding site interactions of activator L-Histidine with active site amino acids
12009884 The X-ray crystallographic structure of the CA I Michigan 1 variant isozyme is reported, both in the presence and absence of a second bound zinc ion coordinated to His 64, His 200, and Arg 67.
15837325 Isothiocyanato sulfonamide thioureas inhibit this enzyme.
14675565 concentrations in nondialyzed chronic kidney disease patients, and the relationship with acidosis, zinc, anemia, and iron supplementation
17314045 study presents the X-ray structure of the foscarnet adduct with CA1 together with the factors governing recognition of such small molecules by a metalloenzyme active site

Recent Publications on CA1:

Pubmed Logo
Self-generated theta oscillations in the hippocampus.
Hippocampal theta rhythm is crucial for spatial memory and is thought to...
3rd November, 2009
[1] Douglas Mental Health University Institute, McGill University, Nat Neurosci. 2009 Nov 1.
DOI Direct Link
The amyloid-ss(25-35) injection into the CA1 region of the neonatal rat hippocampus impairs the long-term memory because of an increase of nitric oxide.
Alzheimer's disease (AD) is characterized by the amyloid beta (Abeta)...
3rd November, 2009
Departamento de Farmacia, Laboratorio de Neurofarmacologia, Edificio "105 Neurosci Lett. 2009 Oct 29.
DOI Direct Link
Vulnerability of Postnatal Hippocampal Neurons to Seizures Varies Regionally with their Maturational Stage.
The mechanism of status epilepticus-induced neuronal death in the immature...
3rd November, 2009
Department of Neurology, David Geffen School of Medicine at UCLA, Los Neurobiol Dis. 2009 Oct 28.
DOI Direct Link
Differential NMDA receptor-dependent calcium loading and mitochondrial dysfunction in CA1 vs. CA3 hippocampal neurons.
Hippocampal CA1 pyramidal neurons are selectively vulnerable to ischemia,...
3rd November, 2009
Laboratory of Neurobiology, National Institute of Neurological Disorders Neurobiol Dis. 2009 Oct 28.
DOI Direct Link
Activity-mediated plasticity of GABA equilibrium potential in rat hippocampal CA1 neurons.
The equilibrium potential (E(GABA-PSC)) for gamma-aminobutyric acid (GABA)...
3rd November, 2009
Neuroscience Research Laboratory, Department of Anesthesiology, Exp Neurol. 2009 Oct 28.
DOI Direct Link

View more research publications.

BioNews Results for CA1

: RSS Logo
BioPortfolio Logo
New findings reported from Federal University describe advances in Alzheimer disease
Pharmacy Choice:  Nov 8 2009 8:10AM Matching: ca1
Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons
Journal of Cerebral Blood Flow & Metabolism:  Oct 21 2009 8:29AM Matching: ca1
Genetic Enhancement of Memory and Long-Term Potentiation but Not CA1 Long-Term Depression in NR2B Transgenic R
Elites TV:  Oct 17 2009 10:20AM Matching: ca1
Neurogranin enhances synaptic strength through its interaction with calmodulin
Nature Chemical Biology:  Oct 7 2009 2:10PM Matching: ca1

Clinical Trials:

Clinical Trials Logo
Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition

Patents:

Patents logo
US Patent No.Title
7588767 Microorganisms for therapy
7596416 Project management tool
7597453 Luminaires using multiple quasi-point sources for unified radially distributed illumination
7597885 Tissue engineered biomimetic hair follicle graft
7598269 Methods and compositions for treating amyloid-related diseases

View more patents.

CA1 results (if any) from reagent suppliers

Google CSE Logo
CA1 pyramidal neuron in a hippocampal slice filled with SBFI ...
Two-photon excitation imaging of calcium influx in a CA1 pyramidal cell spine · Live-cell imaging with Organelle Lights™ ER-RFP and MitoTracker® Deep Red FM ...
http://www.invitrogen.com/site/us/en/home/support/Research-T...

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MGF (mechano-growth factor)
The hippocampi (C-control) and postischemic at 3, 24, 48, and 72 h after reperfusion were divided into vulnerable (CA1) and the resistant (CA2-3, ...
http://www.phoenixpeptide.com/catalog/pnxfoget.php?id=pnxnew...

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Two-photon excitation imaging of calcium influx in a CA1 pyramidal ...
Two-photon excitation imaging of Ca2+ influx in a CA1 pyramidal cell spine. ... CA1 pyramidal neuron in a hippocampal slice filled with SBFI delivered from ...
http://www.invitrogen.com/site/us/en/home/support/Research-T...

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68kDa Neurofilament antibody - Neuronal Marker (ab9035) reviews ...
30 Jun 2006 ... This image was taken with a 20x objective and is from the stratum oriens of CA1 region of the hippocampus. Occasionally the cell soma and ...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=9...

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Monoclonal Anti-KSR (Kinase Suppressor of Ras) antibody produced ...
KSR contain four conserved domains, CA1 through. CA4. CA1 is a domain unique to KSR, CA2 is a putative. Src homology 3 recognition site, CA3 is a cysteine- ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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Anti-CD45RO T cell Monoclonal Antibody
Immunogen: BALB/C mice were immunized with IL-2 dependent T cell line, CA1. Storage: 4º C. Form: 1 ml of purified Ig fraction with sodium azide. ...
http://www.bioreagents.com/products/productDetails/productDe...

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Immunostaining with the New Anti-ACTIVE® p38 Antibody
In the CA1 region of the hippocampus of Syrian hamsters, it was found that transient ischemia ... the p38 inhibitor SB203580, when infused into the CA1 ...
http://www.promega.com/nnotes/nn601/601_02.pdf...

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