BioPortfolio - CA2 - carbonic anhydrase II

CA2

Symbol:

CA2

Name(s):

carbonic anhydrase II

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

CA-II, CAII, Car2

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

18189416

study found the thermodynamic stability of the HCA II mutants was in the following order: HCA IIpwt > H107N > E117A > H107A > H107F > H107Y > H107N/E117A > H107A/E117A

17631639

demonstrate cross-reactivity of this osteoprotegerin antibody in western blots

15836783

cytosolic CA I, II, and XIII are downregulated in neoplastic colorectal mucosa compared to normal colorectal mucosa

16265785

A novel c.232+1G>T mutation was identified in a consanguineous patient. The mutation disrupts the splice site at the 3' end of exon 2 of the messenger RNA precursor.

12501217

This is the first report of a considerably stabilized variant of human CA-II, engineered with a disulfide bridge from a related and unusually stable CA form from Neisseria gonorrhoeae.

16687407

CA II does not enhance NBCe1-A activity

12171926

Data show that inserting histidine residues into the active site cavity of carbonic anhydrase II or III results in rates of proton transfer to the zinc-bound hydroxide that are antagonistic or suppressive with respect to the corresponding single mutants

16475831

a novel phosphorylation-regulated carbonic anhydrase II binding site exists in distal amino acids of the Na+/H+ exchanger tail.

15218065

Results indicate that carbonic anhydrase II activity enhances flux through the sodium bicarbonate cotransporter kNBC1 when the enzyme is bound to kNBC1.

15049705

The primary features in CA-II that drive deviations from the inherent metal ion affinity trend, i.e., the Irving-Williams series, are those that alter the energy required for a bound metal ion to adopt a preferred coordination number and geometry.

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