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ZBTB16


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Symbol:ZBTB16
Name(s):zinc finger and BTB domain containing 16
Type:protein-coding
Organism:Homo sapiens
Synonyms:PLZF, ZNF145
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15968309 Observational study of genetic testing. (HuGE Navigator)
18000064 supports an active role for PLZF and RARalpha-PLZF in leukemogenesis, identifies up-regulation of CRABPI
17881917 PLZF mRNA was expressed in HCECs in vivo and in completely confluent HCECs but not in subconfluent HCECs in vitro.
14527952 PLZF colocalizes with SUMO-1 in the nucleus; lysine 242 in the RD2 domain of human PLZF was identified as the sumoylation site
14645547 PLZF expression maintains a cell in a quiescent state by repressing c-myc expression and preventing cell cycle progression.
17340613 TIMP1 regulates cell proliferation by interacting with the ninth zinc finger domain of PZLF.
15964811 Histone acetyltransferase activity of p300 is required for transcriptional repression by PZLF.
15467736 data indicate that recruitment of HDAC4 is necessary for PLZF-mediated repression in both normal and leukaemic cells
14657020 An inactive mutant of PLZF abolishes expression of p85 alpha PI3K followed by enhanced p70(S6) kinase.
12145280 evidence of a functional interaction between the promyelocytic leukemia zinc finger protein (PLZF) and DRAL/FHL2

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAngiotensin II receptor type 2promyelocytic leukemia zinc finger protein--Pubmed
HPRDB-cell lymphoma 6 proteinpromyelocytic leukemia zinc finger protein--Pubmed
HPRDPolycomb complex protein BMI1promyelocytic leukemia zinc finger protein--Pubmed
HPRDacute myelogenous leukemia 1 translocation 1 protein isoform MTG8bpromyelocytic leukemia zinc finger protein--Pubmed
HPRDacute myelogenous leukemia 1 translocation 1 protein isoform MTG8bpromyelocytic leukemia zinc finger protein--Pubmed
HPRDcell division cycle 2 protein isoform 1promyelocytic leukemia zinc finger protein--Pubmed
HPRDcell division cycle 2 protein isoform 1promyelocytic leukemia zinc finger protein--Pubmed
HPRDheparin-binding EGF-like growth factorpromyelocytic leukemia zinc finger protein--Pubmed
HPRDEstrogen receptor alphapromyelocytic leukemia zinc finger protein--Pubmed
HPRDfour and a half LIM domains 2promyelocytic leukemia zinc finger protein--Pubmed

Recent Publications on ZBTB16:

Pubmed Logo
The role of PLZF in human myeloid development.
Little is known of the molecular regulators that enable production of...
24th October, 2009
Division of Cell and Molecular Biology, University Health Network, Ann N Y Acad Sci. 2009 Sep;1176:150-3.
DOI Direct Link
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.
Some gammadelta and alphabeta T lymphocytes exhibit an "innate" phenotype...
29th September, 2009
Laboratory of Lymphocyte Biology, Dana-Farber Cancer Institute, Harvard Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8. Epub 2009 Jul 15.
DOI Direct Link
The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells.
Stem cells give rise to differentiated cell types but also preserve their...
24th September, 2009
Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411-8540, Science. 2009 Sep 11;325(5946):1394-8.
DOI Direct Link
Spermatogonial culture medium: an effective and efficient nutrient mixture for culturing rat spermatogonial stem cells.
An economical and simplified procedure to derive and propagate fully...
23rd September, 2009
Department of Pharmacology, Howard Hughes Medical Institute, University of Biol Reprod. 2009 Jul;81(1):77-86. Epub 2009 Mar 18.
DOI Direct Link
Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.
Androgen receptor (AR) transcriptional activity is tightly regulated by...
19th September, 2009
Department of Urology, Josephine Nefkens Institute, Erasmus Medical Mol Endocrinol. 2009 Nov;23(11):1776-86. Epub 2009 Sep 17.
DOI Direct Link

View more research publications.

ZBTB16 results (if any) from reagent suppliers

Google CSE Logo
Protein Modification / Acetylation - Protein Modification Antibody
AT4566aNEW, YY1 monoclonal antibody (M05), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H. AT4569aNEW, ZBTB16 monoclonal antibody (M01), ELISA,S-ELISA, H ...
http://www.abgent.com/products/category/protein_modification...

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PLZF (D-9) Antibody sc-28319
Human, ZBTB16, 7704, 11q23.2, NM_001018011, NM_006006 · Q05516 · 176797. Mouse, Zbtb16, 235320, 9 A5.3, NP_001028496 ...
http://www.scbt.com/datasheet-28319-plzf-d-9-antibody.html...

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Abgent - Phosphospecific Antibody
AP3254aNEW, Phospho-YES1-Y537/Phospho-SRC-Y530 Antibody, WB, IHC, DB, E, H. AP3575a, Phospho-ZBTB16-pY334 Antibody, DB, E, H ...
http://www.abgent.com/products/category/phosphospecific...

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Search Results
C3-Zbtb16/J. Stock# - 000100 Strain name - B6.C3-Zbtb16/J JAX® Mice ... C3-Zbtb16/J JAX® Mice Database Site Section: JAX® Mice and services ...
http://www.jax.org/search/Main.jsp?sg=0&qt=suggested&page=3...

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PLZF Antibody (C-term)
... BTB domain-containing protein 16; Zinc finger protein PLZF; Promyelocytic leukemia zinc finger protein; Zinc finger protein 145; ZNF145; PLZF; ZBTB16 ...
http://www.abgent.com/products/catalog_no/AP6664b_PLZF_Antib...

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Search Results
C3-Zbtb16/J. Stock# - 000100 Strain name - B6.C3-Zbtb16/J JAX® Mice Database Site Section: JAX® Mice strain information ...
http://www.jax.org/search/Main.jsp?sg=0&qt=suggested&page=2...

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Abgent - Stem Cell
AP3282aNEW, Phospho-TrkA-Y791 Antibody, WB, DB, E, H. AP3546a, Phospho-Vimentin- S82 Antibody, DB, E, H. AP3575a, Phospho-ZBTB16-pY334 Antibody, DB, E, H ...
http://www.abgent.com/products/category/stem_cell...

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