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ZBTB17


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Symbol:ZBTB17
Name(s):zinc finger and BTB domain containing 17
Type:protein-coding
Organism:Homo sapiens
Synonyms:MIZ-1, ZNF151, ZNF60, pHZ-67
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17947461 MIZ-1 is a new favorable neuroblastoma gene, which may directly or indirectly regulate the expression of other favorable neuroblastoma genes
16167342 replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes
17050536 NDRG2 expression is repressed by Myc via Miz-1-dependent interaction with the NDRG2 core promoter
16537485 Miz-1 transcription factor was identified as an interactor of the SB transposase
17082179 repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction, which explains a copperative interaction between c-MYC and BCL2
16352593 Miz-1 targeting is essential for Myc-mediated apoptosis
12545156 repression of p21 promoter/reporters as well as the endogenous p21 gene by Myc depends on interaction with Miz-1. Expression of Miz-1 increases during hematopoietic differentiation and Miz-1 activates the p21 promoter under conditions of low Myc levels
14739298 Miz-1 has a role in inducing apoptosis along with MAGE-A4

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHomo sapiens chromosome 6zinc finger and BTB domain containing 17Miz1 interacts with p21WAF1 promoter.-Pubmed
HPRDcyclin-dependent kinase inhibitor 2B isoform 1zinc finger and BTB domain containing 17--Pubmed
HPRDcyclin-dependent kinase inhibitor 2B isoform 1zinc finger and BTB domain containing 17--Pubmed
BINDHomo sapiens chromosome 11, reference assembly.zinc finger and BTB domain containing 17Miz1 interacts with DDB2 promoter.-Pubmed
BINDDNA cytosine methyltransferase 3 alpha isoform azinc finger and BTB domain containing 17Miz-1 interacts with Dmnt3a.-Pubmed
HPRDGeneral transcription factor 2 Izinc finger and BTB domain containing 17--Pubmed
HPRDgeneral transcription factor II, i isoform 1Zinc finger protein 151--Pubmed
HPRDhost cell factor C1zinc finger and BTB domain containing 17--Pubmed
HPRDhost cell factor C1zinc finger and BTB domain containing 17--Pubmed
BINDhexokinase 2zinc finger and BTB domain containing 17HKII interacts with Miz-1. This interaction was modeled on a demonstrated interaction between rat HKII and human Miz-1.-Pubmed

Recent Publications on ZBTB17:

Pubmed Logo
Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1.
Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays...
28th February, 2009
Department of Biological Sciences, University of Toledo, Toledo, OH 43606, Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1433-8. Epub 2009 Jan 22.
DOI Direct Link
Investigation of eight candidate genes on chromosome 1p36 for autosomal dominant total congenital cataract.
PURPOSE: To identify the causative gene for autosomal dominant total...
17th December, 2008
Department of Ophthalmology, Flinders University, Adelaide, Australia. Mol Vis. 2008;14:1799-804. Epub 2008 Sep 30.
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.
In response to stimuli that activate p53, cells can undergo either...
10th June, 2008
Institute of Molecular Biology and Tumour Research (IMT), Marburg, EMBO J. 2008 Jun 4;27(11):1563-74. Epub 2008 May 1.
DOI Direct Link
A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain.
The POZ/BTB domain is an evolutionarily conserved motif found in...
19th April, 2008
Molecular Cell Biology Research Group, Institute of Molecular and Cellular J Mol Biol. 2007 Nov 2;373(4):820-6. Epub 2007 Aug 21.
DOI Direct Link
De novo identification of MIZ-1 (ZBTB17) encoding a MYC-interacting zinc-finger protein as a new favorable neuroblastoma gene.
PURPOSE: Neuroblastoma is a childhood cancer that exhibits either a...
28th December, 2007
Department of Anatomy and Cell Biology, College of Medicine, The Clin Cancer Res. 2007 Oct 15;13(20):6001-9.
DOI Direct Link

View more research publications.

ZBTB17 results (if any) from reagent suppliers

Google CSE Logo
Antibody Photo Gallery
Antibody: HPA005789 Anti-ZBTB17 antibody produced in rabbit. Photo 14. Legend: “ Confocal image showing immunostained osteosarcoma cells (U-2 OS). ...
http://www.sigmaaldrich.com/europe/antibody-photo-award/anti...

Thumbshot
Miz-1 (N-17) Antibody sc-5984
De novo identification of MIZ-1 (ZBTB17) encoding a MYC-interacting zinc-finger protein as a new favorable neuroblastoma gene. Clin. Cancer Res. ...
http://www.scbt.com/datasheet-5984-miz-1-n-17-antibody.html...

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Miz-1/ZBTB17 - R&D Systems
Miz-1/ZBTB17. Products By Product Type. All Products for this Molecule · Antibodies · Legal; |; Sitemap. United States (change country); |; (800) 343-
7475 ...
http://www.rndsystems.com/molecule_detail.aspx?m=3302...

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Miz-1 (H-190) Antibody sc-22837
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ZBTB17, 7709, 1p36.13, NM_003443 ...
http://www.scbt.com/datasheet-22837-miz-1-h-190-antibody.htm...

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March 09 NPR Non-priced version.indd
Miz-1/ZBTB17. Human. Goat IgG. AF3760. 100 µg. Neuroplastin. Human. Sheep IgG. AF5174. 100 µg. Nicastrin. Human. Sheep IgG. AF5378. 100 µg. Ninjurin-2 ...
http://www.rndsystems.com/DAM_public/6203.pdf...

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Browse By Molecule < M > - R&D Systems
Miz-1/ZBTB17 · Myosin Heavy Chain · MEK1 · MKK3/MKK6 · MEK2 · MKK3 · MELK · MKK4 · Legal; |; Sitemap. United States (change country); |; (800) 343-7475 ...
http://www.rndsystems.com/molecule_letter.aspx?l=M...

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Transcription Factors & Regulators - R&D Systems
Miz-1/ZBTB17. Transcription Factor Regulators ...
http://www.rndsystems.com/molecule_group.aspx?g=985&r=7...

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