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CXCR4


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Symbol:CXCR4
Name(s):chemokine (C-X-C motif) receptor 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17916907 bone marrow-derived-SDF-1alpha enhances the invasiveness of lung cancer cells by increasing MMP-9 expression through the CXCR4/ERK/NF-kappaB signal transduction pathway
18210030 Observational study of gene-disease association. (HuGE Navigator)
18206727 Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease
18239145 REVIEW: molecular mechanism by which neutrophils accumulate at the advanced plaques
17964871 G-CSF treatment induced reduced expression of CXCR4, VLA-4 and VEGFR-1 in patients with liver failure.
18235009 CXCR4 and CCR7 provide directional migration of uveal melanoma cells toward the liver, the most common site for the formation of uveal melanoma metastases.
18288973 in cultured human breast cancer cells HIV-1 induced apoptosis is mediated via CXCR4 in breast cancer cells that exhibit conformational heterogeneity in comparison with CXCR4 in T-cells
18081034 CXCR4 is not only involved in LPS binding but is also responsible for triggering signalling
11175286 Observational study of genotype prevalence. (HuGE Navigator)
11693435 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBeta adrenergic receptor kinase 2chemokine receptor 4 isoform b--Pubmed
HPRDbeta adrenergic receptor kinase 2CXCR4--Pubmed
HPRDCC chemokine receptor 5chemokine receptor 4 isoform b--Pubmed
HPRDchemokine receptor 5CXCR4--Pubmed
HPRDJanus kinase 2chemokine receptor 4 isoform b--Pubmed
HPRDJanus kinase 2CXCR4--Pubmed
HPRDJanus kinase 3chemokine receptor 4 isoform b--Pubmed
HPRDJanus kinase 3CXCR4--Pubmed
HPRDprotein tyrosine phosphatase, non-receptor type 6 isoform 1chemokine receptor 4 isoform b--Pubmed
HPRDprotein tyrosine phosphatase, non-receptor type 6 isoform 1chemokine receptor 4 isoform b--Pubmed

Recent Publications on CXCR4:

Pubmed Logo
Autoantibodies to the delta-opioid receptor function as opioid agonists and display immunomodulatory activity.
In this report, we show that affinity purified human anti-delta opioid...
3rd November, 2009
Department of Immunobiology, University of Arizona, 1656 E. Mabel Street, J Neuroimmunol. 2009 Oct 29.
DOI Direct Link
Endothelial nitric oxide synthase affects both early and late collateral arterial adaptation and blood flow recovery after induction of hind limb ischemia in mice.
OBJECTIVE: The goals of this study were to determine if endothelial nitric...
3rd November, 2009
Division of Vascular Surgery, University of Massachusetts Medical School, J Vasc Surg. 2009 Oct 29.
DOI Direct Link
Upregulation of Stromal cell derived factor-1alpha in Collagen Vascular Diseases - associated interstitial pneumonias (CVDs-IPs).
OBJECTIVE: We speculated that distinct angiogenic profiles are involved in...
3rd November, 2009
Department of Thoracic Medicine, Interstitial Lung Disease Unit, Medical Pulm Pharmacol Ther. 2009 Oct 27.
DOI Direct Link
Fibrocytes are associated with vascular and parenchymal remodelling in patients with obliterative bronchiolitis.
ABSTRACT: BACKGROUND: The aim of the present study was to explore the...
3rd November, 2009
Respir Res. 2009 Oct 30;10(1):103.
DOI Direct Link
HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy.
BACKGROUND: The clinical significance and cellular sources of residual...
31st October, 2009
INSERM, U563, Toulouse, France. PLoS One. 2009 Oct 30;4(10):e7658.
DOI Direct Link

View more research publications.

Press Releases on CXCR4:

BioPortfolio Logo
Long-Term Data Updates Show Further Extensions of Survival and Delays in Recurrence in Brain Cancer Patients Who Received DCVax(R)-Brain 21st October, 2009 Northwest Biotherapeutics, Inc.

BETHESDA, M.D., Oct. 21 /PRNewswire-FirstCall/ -- Northwest Biotherapeutics, Inc. ("NWBT" or the "Company") (OTC Bulletin Board: NWBO) today announced

Excellent Stem Cell Mobilization and Safety Profile for TG-0054 28th September, 2009 TaiGen Biotechnology Co., Ltd.

TAIPEI, Taiwan, Sept. 28 /PRNewswire-Asia/ -- TaiGen Biotechnology Co., Ltd. announced today that in a phase 1 study in healthy volunteers TG-0054, a chemokine receptor CXCR4 antagonist, was

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance 12th June, 2009 Quest Diagnostics Incorporated

Faster reporting aids physicians in identifying HIV mutations that can inhibit effectiveness of newest class of antiretroviral therapy

MADISON, N.J., June 12 /PRNewswire-FirstCall/ -

Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-CXCR4 Antibody, MDX-1338 27th May, 2009 Medarex, Inc.

-Clinical study planned for relapsed / refractory acute myelogenous leukemia-

PRINCETON, N.J., May 27 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) announced today

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer 21st April, 2009 Medarex, Inc.

- Data Presented at the American Association for Cancer Research -

PRINCETON, N.J., April 21 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) today announced

BioNews Results for CXCR4

: RSS Logo
BioPortfolio Logo
Plerixafor boosts stem cell mobilization in myeloma pts
Cancernetwork.com:  Nov 9 2009 8:19AM Matching: cxcr4
Mast Cells Mediate the Immune Suppression Induced by Dermal Exposure to JP-8 Jet Fuel
Toxicological Sciences:  Oct 27 2009 10:51PM Matching: cxcr4
Long-Term Data Updates Show Further Extensions of Survival and Delays in Recurrence in Brain Cancer Patients Who Received DCVax(R)-Brain
Earthtimes.org:  Oct 21 2009 11:26AM Matching: cxcr4
Plerixafor enhances autologous stem-cell mobilization and transplantation
Reuters Health:  Oct 16 2009 1:08AM Matching: cxcr4
Stem Cell Research - Excellent Stem Cell Mobilization and Safety Profile for TG-0054
NewsRX:  Oct 9 2009 5:36AM Matching: cxcr4
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients

Patents:

Patents logo
US Patent No.Title
7569579 Cyclopropyl compounds as ccr5 antagonists
7585861 HIV inhibiting 1,2,4-triazines
7585867 Substituted thiazolo[4,5-d]pyrimidin-2(3H)-one
7585968 Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
7588767 Microorganisms for therapy

View more patents.

CXCR4 results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
CXCR4 antibodies. ... CXCR4 antibody - BSA and Azide free. Flow Cyt, WB. Rabbit polyclonal ... CXCR4 antibody - Hematopoietic Stem Cell Marker ...
http://www.abcam.com/index.html?t=1366&pt=1&c=537...

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Human CXCR4 antibody: anti-Human CXCR4 (Fusin) antibody
eBioscience technical data sheet for product 16-9999 Functional Grade Purified anti-human CXCR4 (Fusin, CD184) 12G5 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_16/16-...

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CXCR4 antibody (ab2074) | Abcam
Rabbit polyclonal to CXCR4. CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T cell tropic strains of HIV1 fusion and entry of human white
blood ...
http://www.abcam.com/CXCR4-antibody-ab2074.html...

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CXCR4 Antibody (EL) HIV & chemokine receptor
CXCR4 antibody can be used for Western blot at 1:500 to 1:1000 dilution.,
http://www.prosci-inc.com/shop/catalog1/CXCR4-Antibody-p-600...

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Anti-CXCR4 Polyclonal Antibody
Polyclonal Antibody against CXCR4 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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CXCR4 Antibody (NT) HIV & chemokine receptor
CXCR-4 antibody can be used for Western blot at 1 – 2 ug/ml dilution and for immunoprecipitation and immunocytochemistry at 10 ug/ml.,
http://www.prosci-inc.com/shop/catalog1/CXCR4-Antibody-p-600...

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Anti-CXCR4 Polyclonal Antibody
Polyclonal Antibody against CXCR4 for use in Immunocytochemistry, Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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