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CXCR4
| Symbol: | CXCR4 | | Name(s): | chemokine (C-X-C motif) receptor 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17916907 |
bone marrow-derived-SDF-1alpha enhances the invasiveness of lung cancer cells by increasing MMP-9 expression through the CXCR4/ERK/NF-kappaB signal transduction pathway |
| 18210030 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18206727 |
Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease |
| 18239145 |
REVIEW: molecular mechanism by which neutrophils accumulate at the advanced plaques |
| 17964871 |
G-CSF treatment induced reduced expression of CXCR4, VLA-4 and VEGFR-1 in patients with liver failure. |
| 18235009 |
CXCR4 and CCR7 provide directional migration of uveal melanoma cells toward the liver, the most common site for the formation of uveal melanoma metastases. |
| 18288973 |
in cultured human breast cancer cells HIV-1 induced apoptosis is mediated via CXCR4 in breast cancer cells that exhibit conformational heterogeneity in comparison with CXCR4 in T-cells |
| 18081034 |
CXCR4 is not only involved in LPS binding but is also responsible for triggering signalling |
| 11175286 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 11693435 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Recent Publications on CXCR4: |  |
Autoantibodies to the delta-opioid receptor function as opioid agonists and display immunomodulatory activity.
In this report, we show that affinity purified human anti-delta opioid... | 3rd November, 2009
| Department of Immunobiology, University of Arizona, 1656 E. Mabel Street,
| J Neuroimmunol. 2009 Oct 29.
DOI Direct Link |
Endothelial nitric oxide synthase affects both early and late collateral arterial adaptation and blood flow recovery after induction of hind limb ischemia in mice.
OBJECTIVE: The goals of this study were to determine if endothelial nitric... | 3rd November, 2009
| Division of Vascular Surgery, University of Massachusetts Medical School,
| J Vasc Surg. 2009 Oct 29.
DOI Direct Link |
Upregulation of Stromal cell derived factor-1alpha in Collagen Vascular Diseases - associated interstitial pneumonias (CVDs-IPs).
OBJECTIVE: We speculated that distinct angiogenic profiles are involved in... | 3rd November, 2009
| Department of Thoracic Medicine, Interstitial Lung Disease Unit, Medical
| Pulm Pharmacol Ther. 2009 Oct 27.
DOI Direct Link |
Fibrocytes are associated with vascular and parenchymal remodelling in patients with obliterative bronchiolitis.
ABSTRACT: BACKGROUND: The aim of the present study was to explore the... | 3rd November, 2009
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| Respir Res. 2009 Oct 30;10(1):103.
DOI Direct Link |
HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy.
BACKGROUND: The clinical significance and cellular sources of residual... | 31st October, 2009
| INSERM, U563, Toulouse, France.
| PLoS One. 2009 Oct 30;4(10):e7658.
DOI Direct Link |
→View more research publications. |
Press Releases on CXCR4:
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| Long-Term Data Updates Show Further Extensions of Survival and Delays in Recurrence in Brain Cancer Patients Who Received DCVax(R)-Brain |
21st October, 2009 |
Northwest Biotherapeutics, Inc. |
BETHESDA, M.D., Oct. 21 /PRNewswire-FirstCall/ -- Northwest Biotherapeutics, Inc. ("NWBT" or the "Company") (OTC Bulletin Board: NWBO) today announced
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| Excellent Stem Cell Mobilization and Safety Profile for TG-0054 |
28th September, 2009 |
TaiGen Biotechnology Co., Ltd. |
TAIPEI, Taiwan, Sept. 28 /PRNewswire-Asia/ -- TaiGen Biotechnology Co.,
Ltd. announced today that in a phase 1 study in healthy volunteers TG-0054, a
chemokine receptor CXCR4 antagonist, was
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| New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance |
12th June, 2009 |
Quest Diagnostics Incorporated |
Faster reporting aids physicians in identifying HIV mutations that can inhibit effectiveness of newest class of antiretroviral therapy
MADISON, N.J., June 12 /PRNewswire-FirstCall/ -
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| Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-CXCR4 Antibody, MDX-1338 |
27th May, 2009 |
Medarex, Inc. |
-Clinical study planned for relapsed / refractory acute myelogenous leukemia-
PRINCETON, N.J., May 27 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) announced today
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| Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer |
21st April, 2009 |
Medarex, Inc. |
- Data Presented at the American Association for Cancer Research -
PRINCETON, N.J., April 21 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) today announced
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CXCR4 results (if any) from reagent suppliers | 
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