Saturday November 21 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

ADAM12


Suggest Content
Advertise Here
Gene DB Home
Symbol:ADAM12
Name(s):ADAM metallopeptidase domain 12 (meltrin alpha)
Type:protein-coding
Organism:Homo sapiens
Synonyms:MCMP, MCMPMltna, MLTN, MLTNA
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16453284 Observational study of gene-disease association. (HuGE Navigator)
17440933 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17846126 Observational study of gene-disease association. (HuGE Navigator)
18081311 These results indicate unique enzymatic properties of ADAM12 among the members of the ADAM family of metalloproteinases.
17701664 ADAM12 may be a useful addition to early screening for trisomy 18 alongside other chromosomal anomalies, particularly if biochemical screening can occur before 10 weeks.
17465398 ADAM 12 is an efficient second-trimester marker for Down syndrome.
15358598 Expression in human colonic cell lines.
15574885 ADAM12 is instrumental in myogenic cell differentiation.
15509542 ADAM12m is highly expressed in human glioblastomas and may play a role in the prominent proliferation of the glioblastomas through shedding of heparin-binding epidermal growth factor
16869727 ADAM12-S stimulates bone growth by modulating chondrocyte proliferation and maturation through mechanisms probably involving both metalloprotease and adhesion activities.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActinin alpha 2a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDAlpha actinin 2a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDactinin, alpha 2ADAM 12--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDinsulin-like growth factor binding protein 3a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDinsulin-like growth factor binding protein 3a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDinsulin-like growth factor binding protein 3 isoform a precursora disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDIGF binding protein 5a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDinsulin-like growth factor binding protein 5ADAM 12--Pubmed

Recent Publications on ADAM12:

Pubmed Logo
Targeting ADAM12 in human disease: head, body or tail?
ADAM12/meltrin alpha is a type I transmembrane multidomain protein...
23rd October, 2009
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Curr Pharm Des. 2009;15(20):2300-10.
Adam12 plays a role during uterine decidualization in mice.
In mouse, decidualization is characterized by the proliferation of stromal...
21st October, 2009
State Key Laboratory of Reproductive Biology, Institute of Zoology, Cell Tissue Res. 2009 Oct 20.
DOI Direct Link
A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.
Several observations suggest that neurotoxicity in Alzheimer's disease...
20th October, 2009
INSERM, U744, Universite de Lille 2, Institut Pasteur de Lille, BP 245, 1, Neurosci Lett. 2009 Oct 21.
DOI Direct Link
LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.
Most epilepsy genes encode ion channels, but the LGI1 gene responsible for...
3rd October, 2009
Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale Mol Cell Neurosci. 2009 Sep 29.
DOI Direct Link
alpha9beta1 Integrin in melanoma cells can signal different adhesion states for migration and anchorage.
Cell surface integrins are the primary receptors for cell migration on...
3rd October, 2009
Department of Biomedical Sciences, The Faculty of Health Sciences, and Exp Cell Res. 2009 Nov 15;315(19):3312-24. Epub 2009 Sep 29.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6426186 Bone remodeling genes
7067636 Anti-pro 1017 antibodies
7074593 PRO 703 nucleic acids
7081521 Anti-PRO788 antibodies
7105640 Anti-pro792 antibodies

View more patents.

ADAM12 results (if any) from reagent suppliers

Google CSE Logo
ADAM12 antibody (ab28747) | Abcam
Goat polyclonal to ADAM12. ADAM12 is a member of the ADAM (a disintegrin and metalloprotease like domain) family. Two forms of ADAM12 have been described:
...
http://www.abcam.com/adam12-antibody-ab28747.html...

Thumbshot
ADAM12 Antibody (NT) ADAM12
ADAM12 antibody was raised against a synthetic peptide near the N-terminus of ADAM12.,
http://www.prosci-inc.com/shop/catalog1/ADAM12-Antibody-p-26...

Thumbshot
ADAM12 antibody - Cytoplasmic domain (ab39156) | Abcam
Rabbit polyclonal to ADAM12 - Cytoplasmic domain. ADAM12 is a member of the ADAM (a disintegrin and metalloprotease like domain) family. Two forms of ADAM12 ...
http://www.abcam.com/adam12-antibody-cytoplasmic-domain-ab39...

Thumbshot
ADAM Antibody / ADAM Antibodies
ADAM12 (C-20) Antibody, sc-16527, goat IgG, internal (h), WB, IF, ELISA ... ADAM12 (H-210) Antibody, sc-25579, rabbit IgG, 700-909 (h), WB, IP, IF, ELISA
...
http://www.scbt.com/table-adam.html...

Thumbshot
ADAM12 antibody - Aminoterminal end catalytic domain (ab28225) | Abcam
Rabbit polyclonal to ADAM12 - Aminoterminal end catalytic domain. ADAM12 is a member of the ADAM (a disintegrin and metalloprotease like domain) family.
http://www.abcam.com/adam12-antibody-aminoterminal-end-catal...

Thumbshot
BIOMOL International - Anti-ADAM12, Catalytic Domain
Immunogen: recombinant human ADAM12 catalytic domain. Recognizes all latent and active forms of human ADAM12. Supplied as rabbit serum. ...
http://www.biomol.com/Online_Catalog/Online_Catalog/Products...

Thumbshot
ADAM12 antibodies: Signal Transduction > Cytoskeleton / ECM > Cell ...
ADAM12 antibodies. ... ADAM12 antibody - Aminoterminal end catalytic domain ... ADAM12 antibody - Cytoplasmic domain ...
http://www.abcam.com/index.html?t=69698&pt=1&c=748&ei=&mu=ra...

Thumbshot

Search Bioportfolio and other Life Science Sites for ADAM12, or search for ADAM12 on BioPortfolio's antibody search engine.
This page has been viewed 397 times
Recent Search Terms used to find this page:
a disintegrin and metallopeptidase domain 12 meltrin alpha | symbols for domain antibody | ADAM 12 precursor A disintegrin and metalloproteinase domain 12 | Polyclonal anti-human ADAM 12 antibody | ADAM12 | ADAM12 symbol | adam 12 pair | ADAM 12-S primer | ADAM metallopeptidase domain 12 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.