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HMGA2


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Symbol:HMGA2
Name(s):high mobility group AT-hook 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:BABL, HMGI-C, HMGIC, LIPO, STQTL9
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17935122 the different profiles of HMGA2 protein expression in post-pubertal testicular tumours could represent a valuable diagnostic tool in some cases in which the histological differential diagnosis is problematic
17767157 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18193045 Genome-wide association study of gene-disease association. (HuGE Navigator)
17943974 HMGA2 stand-alone marker expression has a high potential to improve diagnoses of follicular neoplasms of the thyroid.
17767157 variant of HMGA2 is associated with adult and childhood height in the general population
17957144 Expression of HMGA2 represents an early event during cancer progression.
17917958 HMGA2 has a role in chronic myelogenous leukemia [comment]
17917968 up-regulation of HMGA2 expression is correlated to the undifferentiated phenotype of leukaemic cells accumulating during progression of chronic phase to blast crisis
17654722 The diagnostic usefulness of HMGA2 rearrangements to differentiate between AAM and other tumors of the lower genital tract may be limited due to the their low frequency
17854665 HMGA2 overexpression is associated with polycythemia vera

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDnuclear factor of kappa light polypeptide gene enhancer in B-cells 1high mobility group AT-hook 2 isoform a--Pubmed
HPRDnuclear factor of kappa light polypeptide gene enhancer in B-cells 1high mobility group AT-hook 2 isoform a--Pubmed

Recent Publications on HMGA2:

Pubmed Logo
An interview with Dr. Marcus E. Peter on his highly cited paper published in Cell Cycle.
OBJECTIVE: To detect the expression of high mobility group protein A...
31st October, 2009
Cell Cycle. 2009 Aug;8(15):2325. Epub 2009 Aug 1.
Insights into the Regulation of a Common Variant of HMGA2 Associated with Human Height During Embryonic Development.
Early genetic studies in the mouse and chicken identified the HMGA...
21st October, 2009
Neural Stem Cells, Institute of Medical Biology, Agency for Science Stem Cell Rev Rep. 2009 Oct 16.
DOI Direct Link
HMGA2-NFIB fusion in a pediatric intramuscular lipoma: a novel case of NFIB alteration in a large deep-seated adipocytic tumor.
Lipomas are frequently characterized by aberrations of the 12q13...
20th October, 2009
Faculty of Medicine, Laboratory of Solid Tumor Genetics, Nice University Cancer Genet Cytogenet. 2009 Nov;195(1):66-70.
DOI Direct Link
Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.
Imatinib is used to treat chronic myelogenous leukemia (CML), but...
20th October, 2009
INSERM U895, Cell Death, Differentiation and Cancer Team, Faculte de Mol Cancer Ther. 2009 Jul;8(7):1924-33. Epub 2009 Jun 30.
DOI Direct Link
Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma.
The discrimination between well-differentiated liposarcomas/atypical...
13th October, 2009
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Mod Pathol. 2009 Oct 9.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Biomarkers in Tumor Tissue Samples From Young Patients With Very Low Risk Wilms Tumors

Patents:

Patents logo
US Patent No.Title
7612063 Substituted quinobenzoxazine analogs
7163948 Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
7238792 Foldable polymers as probes
7244564 HMGA alleles and use of the same as genetic markers for growth, fatness, meat quality, and feed efficiency traits
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof

View more patents.

HMGA2 results (if any) from reagent suppliers

Google CSE Logo
HMGA2 antibody (ab41878) | Abcam
Rabbit polyclonal to HMGA2. The HMGA2 protein is a member of the High Mobility Group (HMG) family of non-histone chromatin proteins.
http://www.abcam.com/HMGA2-antibody-ab41878.html...

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HMGA2 monoclonal antibody (M01)
HMGA2 (NP_003474, 1 a.a. ~ 93 a.a) partial recombinant protein with GST tag. ... Detection limit for recombinant GST tagged HMGA2 is approximately 0.1ng/ml ...
http://www.abgent.com/products/catalog_no/AT2383a_HMGA2_mono...

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HMGA2 antibodies: Developmental Biology > Post embryonic ...
HMGA2 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab41878 · HMGA2 antibody. WB. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=14178&pt=1&c=4621&ei=&mu=r...

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HMGA2 - R&D Systems
HMGA2, previously known as HMGIC, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. ...
http://www.rndsystems.com/molecule_detail.aspx?m=2991...

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HMGI-C (S-15) Antibody sc-23684
Overexpression of HMGA2 relates to reduction of the let-7 and its ... HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from ...
http://www.scbt.com/datasheet-23684-hmgi-c-s-15-antibody.htm...

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LIN28A (A177) Antibody #3978
The let-7 miRNAs have been implicated in repression of oncogenes such as ras, myc and Hmga2 (3). It has recently been shown that LIN28A and LIN28B are ...
http://www.cellsignal.com/products/3978.html...

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Abgent - Chromatin and Regulation Antibodies - Chromatin_regulation
AT2374aNEW, HIST1H3D monoclonal antibody (M01), ELISA,IF,IHC-P,WB-Ce,WB-Re, H. AT2383aNEW, HMGA2 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/nuclear_signaling/ch...

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high mobility group AT-hook 2 | elisa hmga2 | hmga2 | hmga2 gene city of hope | matrix associated at hook | high mobility group AT-hook protein | hook2 | EMBO J. 2009 Feb 18 28(4):347-58. Epub 2009 Jan 15. Links | HMGA2 binding | .


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