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PABPN1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 11222452 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16378590 |
PABPN1 has a role in myogenesis |
| 17229142 |
the N-terminal domain of PABPN1 has a role in oculopharyngeal muscular dystrophy |
| 16239242 |
Recruitment of HSP70 and HSC70 into the cell nucleus reduced mutant PABPN1 aggregation in a HeLa cell culture model. |
| 11689481 |
The autosomal dominant form of this disease is caused by short expansions of a (GCG)(6) repeat to (GCG)(8-13) in the PABPN1 gene. |
| 15694141 |
All families carrying the mutation (GCG)(11)(GCA)(3)(GCG) shared a common ancestral haplotype and the age of the mutation was estimated in 37-53 generations by a composite likelihood method. |
| 15755680 |
Expanded PABPN1, presumably via the toxic effects of its polyalanine tract, leads to inclusion formation and neurodegeneration in both the transgenic mouse and the human. |
| 17418585 |
This is the first report directly indicating that nuclear aggregation in OPMD may reflect an active process by which cells sequester and inactivate the soluble toxic form of expPABPN1. |
| 17005403 |
Mutation of the PABPN1 in oculopharyngeal muscular dystrophy (OPMD) provokes premature senescence in dividing myoblasts, that may be due to intranuclear toxic aggregates. |
| 16101680 |
Cytoplasmic targeting of mutant PABPN1 suppresses protein aggregation and toxicity in oculopharyngeal muscular dystrophy. | →View more information from publications. |
Recent Publications on PABPN1: |  |
Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor.
Poly(A) tails of mRNAs are synthesized in the cell nucleus with a defined... | 7th October, 2009
| Institute of Biochemistry and Biotechnology, Martin-Luther-University
| J Biol Chem. 2009 Aug 21;284(34):22803-14. Epub 2009 Jun 9.
DOI Direct Link |
Cognitive impairment and reduced life span of oculopharyngeal muscular dystrophy homozygotes.
OBJECTIVE: To assess the evolution and life expectancy in patients with... | 15th September, 2009
| Department of Neurology, Hillel Yaffe Medical Center, PO Box 169, Hadera,
| Neurology. 2009 Aug 25;73(8):596-601.
DOI Direct Link |
Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1.
Genomic instability at loci with tandem arrays of simple repeats is the... | 31st July, 2009
| Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de
| PLoS One. 2009 Jul 29;4(7):e6418.
DOI Direct Link |
Bortezomib Induces the Formation of Nuclear poly(A) RNA Granules Enriched in Sam68 and PABPN1 in Sensory Ganglia Neurons.
The ubiquitin-dependent proteasome system (UPS) is the major pathway... | 18th July, 2009
| Department of Anatomy and Cell Biology and "Centro de Investigacion
| Neurotox Res. 2009 Jul 16.
DOI Direct Link |
Oculopharyngeal muscular dystrophy: phenotypic and genotypic characteristics of 9 Polish patients.
BACKGROUND AND PURPOSE: Oculopharyngeal muscular dystrophy (OPMD) is... | 18th July, 2009
| Katedra i Klinika Neurologii WUM w Warszawie, Samodzielny Publiczny
| Neurol Neurochir Pol. 2009 Mar-Apr;43(2):113-20.
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→View more research publications. |
PABPN1 results (if any) from reagent suppliers | 
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PABPN1 Antibody / PABPN1 Antibodies
PABPN1 Antibody / PABPN1 Antibodies. ... PABPN1 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-pabpn1.html...
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PABPN1 antibodies: Chromatin and Nuclear Signaling > Chromatin ...
PABPN1 antibodies. ... Image Abreview Publication. ab75855 · PABPN1 antibody [ EP3000Y]. Flow Cyt, IP, WB, ICC/IF, IHC-P. Images. Rabbit monoclonal ...
http://www.abcam.com/index.html?t=151055&pt=1&c=3585&ei=&mu=...
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PABPN1 Antibody / PABPN1 Antibodies
PABPN1 Antibody / PABPN1 Antibodies. ... PABPN1 specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ...
http://www.scbt.com/ko/table-pabpn1.html...
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All P bodies/GW bodies | Abcam
PABPN1 antibody [EP3000Y]. Flow Cyt, IP, WB, ICC/IF, IHC-P. Images. Rabbit monoclonal. Reacts with: Hu, Ms. Terms and conditions · Legal · Privacy policy
...
http://www.abcam.com/index.html?c=3690...
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PABPN1 siRNA (h) sc-44819
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: PABPN1 (h)-PR: sc-44819-PR, 20 µl ...
http://www.scbt.com/ko/datasheet-44819-pabpn1-sirna-h.html...
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Peptide-affinity Purified Polyclonal Antibody to Influenza A H1N1 NS
... of cellular pre-mRNAs which include the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). ...
http://imgenex.com/antibody_details.php?catalog=IMG-6461A&id...
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P1-PC
HPA000637, Anti-PABPN1 antibody produced in rabbit, (polyclonal), affinity isolated antibody, human ... PABPN1(8106), human, IHC (p), PA, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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