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CALR


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Symbol:CALR
Name(s):calreticulin
Type:protein-coding
Organism:Homo sapiens
Synonyms:CRT, FLJ26680, RO, SSA, cC1qR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17982021 Calreticulin expression in the clonal plasma cells of patients with systemic light-chain (AL-) amyloidosis is associated with response to high-dose melphalan
17959730 Calreticulin stimulates the anti-oxidant pathway and contributes to short-term hypoxia-induced protection in A549 type II alveolar epithelial cells.
17947714 cell surface calreticulin, a known innate immunity receptor, which has been previously proposed as a culprit in autoimmunity, plays a critical role in shared epitope-triggered signal transduction.
17655857 Two novel mutations in the CALR gene were identified.
16951181 Novel mechanism by which calareticulin is involved in the regulation of radiosensitivity and radiation-induced apoptosis in malignant glioma cells.
17390051 These results show that Calreticulin is likely to play a pivotal role in the differentiation of human colonic adenocarcinomas.
16140380 C1q functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both gC1qR and cC1qR/CR.
12065601 Regulation of expression during induction of differentiation in human myeloid cells; evidence for remodeling of the endoplasmic reticulum
12704787 identification as a nuclear matrix protein associated with human colon cancer
15596044 Up-regulation of calreticulin is associated with bladder cancer

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDapolipoprotein B precursorcalreticulin precursor--Pubmed
HPRDapolipoprotein B precursorcalreticulin precursor--Pubmed
HPRDamyloid beta A4 protein precursor, isoform acalreticulin precursor--Pubmed
HPRDAndrogen receptorcalreticulin precursor--Pubmed
HPRDandrogen receptor isoform 1Calreticulin--Pubmed
HPRDBeta 2 microglobulincalreticulin precursor--Pubmed
HPRDbeta-2-microglobulin precursorCalreticulin--Pubmed
HPRDCalreticulincoagulation factor VIII isoform a precursor--Pubmed
HPRDCalreticulinfibrillin 1--Pubmed
HPRDCalreticulinthyroid stimulating hormone receptor--Pubmed

Recent Publications on CALR:

Pubmed Logo
Identifying Genes for Establishing a Multigenic Test for Hepatocellular Carcinoma Surveillance in Hepatitis C Virus-Positive Cirrhotic Patients.
In this study, we used the Affymetrix HG-U133A version 2.0 GeneChips to...
29th October, 2009
1Department of Biostatistics, 2Massey Cancer Center, 3Division of Cancer Epidemiol Biomarkers Prev. 2009 Oct 27.
DOI Direct Link
Glycoproteomic analysis of human lung adenocarcinomas using glycoarrays and tandem mass spectrometry: differential expression and glycosylation patterns of vimentin and fetuin A isoforms.
Human lung cancer is a major cause of cancer mortality worldwide. Advances...
29th September, 2009
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Protein J. 2009 May;28(3-4):148-60.
DOI Direct Link
Mapping the complement C1q binding site in Haemonchus contortus calreticulin.
Haemonchus contortus is an economically important gastrointestinal...
22nd July, 2009
Division of Biochemistry, Indian Veterinary Research Institute, Izatnagar, Mol Biochem Parasitol. 2009 Jul;166(1):42-6. Epub 2009 Feb 24.
DOI Direct Link
Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder.
Impaired endoplasmic reticulum (ER) stress response has been suggested as...
14th March, 2009
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Int J Neuropsychopharmacol. 2009 Feb;12(1):33-43. Epub 2008 Sep 4.
DOI Direct Link
Endoplasmic reticulum stress response in murine kidney exposed to acute hypobaric hypoxia.
Any perturbation in the normal functioning of endoplasmic reticulum (ER),...
16th September, 2008
Institute of Genomics and Integrative Biology, Mall Road, Delhi, India. FEBS Lett. 2008 Jul 23;582(17):2521-6. Epub 2008 Jun 20.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6772149 System and method for identifying facts and legal discussion in court case law documents
6759508 Compositions and methods for the therapy and diagnosis of lung cancer
6753314 Protein-protein complexes and methods of using same
6741365 Photometric calibration of liquid volumes

View more patents.

CALR results (if any) from reagent suppliers

Google CSE Logo
CALR Recombinant Protein calreticulin, Sicca syndrome antigen A ...
CALR Recombinant Protein from ProSci Incorporated. Protein GI number 4757900, accesion number NP_004334.,
http://www.prosci-inc.com/shop/catalog1/CALR-Recombinant-Pro...

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C4606 Anti-Calreticulin antibody produced in rabbit IgG fraction ...
WH0000811M1, Monoclonal Anti-CALR antibody produced in mouse. Array, CSAA1, Panorama® Antibody Microarray - Cell Signaling Kit ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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CALR Antibody / CALR Antibodies
CALR El siRNA, el plásmido del sHRNA y los silenciadores especificos del gene de las partículas de Lentiviral del shRNA están también disponibles. ...
http://www.scbt.com/es/table-calr.html...

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Antibodies to Calcium-Associated Proteins
HPA002242, Anti-CALR antibody produced in rabbit, affinity isolated antibody ... human ... CALR(811), canine, human, ARR, IF (i), IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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CALR Antibody / CALR Antibodies
CALR Antibody / CALR Antibodies. ... CALR spécifique siARN, shARN Plasmide et shARN Particules Lentivirales Ciblant des Gènes disponible. ...
http://www.scbt.com/fr/table-calr.html...

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Calreticulin Monoclonal Antibody Calreticulin - A major Ca(2+ ...
Additional Names. RO, CRT, SSA, cC1qR, FLJ26680, CALR. Calreticulin Monoclonal Antibody. Description. Western blot analysis using calreticulin monoclonal ...
http://www.prosci-inc.com/shop/catalog1/Calreticulin-Monoclo...

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CALR Antibody / CALR Antibodies
CALR Antibody / CALR Antibodies. ... CALR specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/ja/table-calr.html...

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