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CAMK4


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Symbol:CAMK4
Name(s):calcium/calmodulin-dependent protein kinase IV
Type:protein-coding
Organism:Homo sapiens
Synonyms:CaMK-GR, MGC36771
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17909078 a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
14701808 sequestration of CaMKK may be the molecular mechanism by which catalytically inactive mutants of CaMKIV exert their "dominant-negative" functions within the cell
15591024 calcium/CaMKIV signaling pathway may play an important role in the excitation-mediated regulation of corticotropin releasing hormone synthesis
12065094 CaMKIV proteins were found in the nucleus of epithelial ovarian cancer tissue. CaMKIV expression was significantly associated with clinical stage (P<0.01), histological grade (P<0.01), and clinical outcome (P<0.01).
15665723 the function of CaMK II is essential for PAF-induced macrophage priming, while CaMK IV is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events
15841182 Results identify calcium/calmodulin-dependent kinase IV as being responsible for the increased expression of CREM and the decreased production of interleukin-2 in systemic lupus erythematosus T cells.
15143065 the Ca(2+)/CaM binding-autoinhibitory domain of CaMKIV is required for association of the kinase with PP2A
15840651 CaMKIV is expressed in human sperm and may have a role in the regulation of human sperm motility

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCalcium/calmodulin dependent protein kinase IVcalcium/calmodulin-dependent protein kinase 1 alpha isoform b--Pubmed
HPRDcalcium/calmodulin-dependent protein kinase IVcalcium/calmodulin-dependent protein kinase kinase 2 beta isoform 1--Pubmed
HPRDcalcium/calmodulin-dependent protein kinase IVcalcium/calmodulin-dependent protein kinase kinase 2 beta isoform 1--Pubmed
BINDcalcium/calmodulin-dependent protein kinase IVcalcineurin binding protein 1CAMK4 (CAMKIV) interacts with CABIN1.-Pubmed

Recent Publications on CAMK4:

Pubmed Logo
Lanthanum chloride impairs memory, decreases pCaMK IV, pMAPK and pCREB expression of hippocampus in rats.
Surveys have reported that rare-earth elements (REEs) could impair...
29th September, 2009
Department of Toxicology, School of Public Health, China Medical Toxicol Lett. 2009 Oct 28;190(2):208-14. Epub 2009 Jul 28.
DOI Direct Link
Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification.
Similar to phosphorylation, GlcNAcylation (the addition of O-GlcNAc to...
29th September, 2009
Department of Biological Chemistry, The Johns Hopkins University School of J Biol Chem. 2009 Aug 7;284(32):21327-37. Epub 2009 Jun 8.
DOI Direct Link
Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex.
Fragile X syndrome is caused by a lack of fragile X mental retardation...
2nd September, 2009
Department of Physiology, Faculty of Medicine, University of Toronto, 1 J Biol Chem. 2009 Jul 10;284(28):18953-62. Epub 2009 May 12.
DOI Direct Link
Antipsychotics affect multiple calcium calmodulin dependent proteins.
Calcineurin is a calmodulin (CaM) dependent protein phosphatase recently...
25th August, 2009
Department of Psychiatry, London Health Sciences Centre-University Campus, Neuroscience. 2009 Jul 7;161(3):877-86. Epub 2009 Mar 13.
DOI Direct Link
Major signaling pathways in migrating neuroblasts.
Neuronal migration is a key process in the developing and adult brain....
12th August, 2009
Department of Clinical Neurobiology, Interdisciplinary Center for Front Mol Neurosci. 2009;2:7. Epub 2009 Jul 24.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6706867 DNA array sequence selection
6727063 Single nucleotide polymorphisms in genes
6753314 Protein-protein complexes and methods of using same
6994848 Lactobacillus paracasei strain GM-080 for treating allergy related diseases

View more patents.

CAMK4 results (if any) from reagent suppliers

Google CSE Logo
CAMK4 Antibody (Center H353)
Formalin-fixed and paraffin-embedded human brain tissue reacted with CAMK4 ( Center H353), which was peroxidase-conjugated to the secondary antibody, ...
http://www.abgent.com/products/catalog_no/AP7211c_CAMK4_Anti...

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CAMK4 Active (C0245) - Datasheet
cortex.1 CAMK4 is involved in neural activity-dependent signaling in the neuronal nucleus and is ... Kinase Solution – Dilute the Active CAMK4 (0.1 µg/µl
) ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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Page 1 of 2 e-mail: info@rockland-inc.com Visit our website at ...
CAM kinase-GR, CAMK4 and CaMK IV) is a ... Immunochemicals' Anti-CAMK4 antibody was diluted 1:500 to detect CAMK4 in human brain cortex tissue. ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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HDAC4 antibody, HDAC4 [HDAC-144] Antibody, Mouse Monoclonal Antibody
Ptm: Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3. ...
http://www.genwaybio.com/product_info.php?products_id=190739...

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PanoramaTM Human Protein Function Microarrays: A New Approach to ...
calmodulin-dependent kinase IV (CAMK4) was detected on a human ... Only pairs of labeled control spots and the set of four CAMK4 ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General_...

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Abgent - Phosphorylation Antibodies - Phosphorylation
AP7211cNEW, CAMK4 Antibody (Center H353), WB, IHC, E, H. AT1379a, CAMK4 monoclonal antibody (M01), ELISA,IF,IHC-P,RNAi-Ab,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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CaMKIV (H-146) Antibody sc-9036
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CAMK4, 814, 5q22.1, NM_001744 ...
http://www.scbt.com/datasheet-9036-camkiv-h-146-antibody.htm...

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