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CAMK2A


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Symbol:CAMK2A
Name(s):calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
Type:protein-coding
Organism:Homo sapiens
Synonyms:CAMKA, KIAA0968
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17221287 To characterize the human alphaCaMKII promoter, a promoter-reporter gene assay using different cell lines, was developed.
17603807 Amphetamine sensitization in rats, an animal model of schizophrenia, results in significant increase in CaMKII beta and a nonsignificant increase in CaMKII alpha mRNA.
16247765 The expression of CaMKIIalpha is significantly elevated in depression (29%), but not in schizophrenia or bipolar disorder, compared to healthy controls.
17627985 Skeletal muscle CaMKII kinase isoform expression and serum response factor phosphorylation is higher with endurance-type exercise training, adaptations that are restricted to active muscle.
17632540 alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression
14722083 measured differences in CaMKII binding affinities for CaM play a minor role in the autophosphorylation of the enzyme, largely dictated by autophosphorylation rate for alpha, beta, gamma and delta isoforms
11930170 CaMKII alpha mRNA expression is significantly reduced in the prefrontal cortex of patients with bipolar illness.
11889801 role in cell communication
11710563 Four distinct isoforms of CAMKII were isolated. Two of them were characterized as CaMKII alpha and beta subunits.CaMKII expression is developmentally regulated in human fetal and adult brain
15621017 CaMKII-alpha may be related with beta-amyloid more closely than being involved in tau hyperphosphorylation in Alzheimer's disease

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDactinin, alpha 4calcium/calmodulin-dependent protein kinase IIA isoform 2CAMK2A (CaMKII-alpha) interacts with ACTN4 (alpha-Actinin 4).-Pubmed
HPRDCaMK II alpha subunitN-methyl-D-aspartate receptor subunit 2B precursor--Pubmed
HPRDCaMK II alpha subunit1D-myo-inositol-trisphosphate 3-kinase A--Pubmed
HPRDCaMK II alpha subunitsynaptic Ras GTPase activating protein 1--Pubmed
HPRDCaMK II alpha subunitNMDA receptor 1 isoform NR1-3 precursor--Pubmed
HPRDCaMK II alpha subunitdeath-associated protein kinase 2--Pubmed
HPRDCaMK II alpha subunitCaM-KII inhibitory protein--Pubmed
HPRDcalcium/calmodulin-dependent protein kinase IIA isoform 1CaMKII inhibitory protein--Pubmed
HPRDcalcium/calmodulin-dependent protein kinase IIA isoform 1Death associated protein kinase 2--Pubmed
HPRDcalcium/calmodulin-dependent protein kinase IIA isoform 1Glutamate receptor ionotropic, N-methyl D-aspartate 1--Pubmed

Recent Publications on CAMK2A:

Pubmed Logo
Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats.
OBJECTIVES AND METHODS: We have previously demonstrated that quetiapine...
12th September, 2009
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Pharmacogenet Genomics. 2009 Aug;19(8):600-12.
DOI Direct Link
Antipsychotics affect multiple calcium calmodulin dependent proteins.
Calcineurin is a calmodulin (CaM) dependent protein phosphatase recently...
25th August, 2009
Department of Psychiatry, London Health Sciences Centre-University Campus, Neuroscience. 2009 Jul 7;161(3):877-86. Epub 2009 Mar 13.
DOI Direct Link
Enhanced CaMKII activity and spatial cognitive function in SAMP6 mice.
Senescence-accelerated mouse prone 6 (SAMP6) mice exhibit increased...
14th August, 2009
Research Resources Center, RIKEN Brain Science Institute, Saitama, Japan. Behav Neurosci. 2009 Jun;123(3):527-32.
DOI Direct Link
Effects of penicillin-induced developmental epilepticus on hippocampal regenerative sprouting, related gene expression and cognitive deficits in rats.
For the purpose of investigating the long-term effects of seizures in...
14th July, 2009
Neurology Laboratory, Soochow University Affiliated Children's Hospital, Toxicol Lett. 2009 Jul 24;188(2):161-6. Epub 2009 Apr 10.
DOI Direct Link
Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning.
Ca2+/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) is an...
30th June, 2009
Department of Information Physiology, National Institute for Physiological J Neurosci. 2009 Jun 10;29(23):7607-18.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

CAMK2A results (if any) from reagent suppliers

Google CSE Logo
Camk2a antibody, Calcium/calmodulin-dependent protein kinase type ...
Buy quality rabbit Camk2a antibody (interacts with cow chicken human mouse rat xenopus), anti-Camk2a, Calcium/calmodulin-dependent protein kinase type II ...
http://www.genwaybio.com/product_info.php?products_id=20008...

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CAMK2A (CAMK2 alpha) Antibody (C-term)
CAMK2A (CAMK2 alpha) Antibody (C-term). Western blot analysis of anti-CAMK2 alpha C-term Pab (Cat. #AP7206b) in 293 cell lysate. ...
http://www.abgent.com/products/catalog_no/AP7206b...

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CaMKII (M-176) Antibody sc-9035
Human, CAMK2A, 815, 5q33.1, NM_015981, NM_171825 · Q9UQM7 · 114078. Mouse, Camk2a, 12322, 18 E1, P11798, N/A. Mouse, Camk2a, 12322, 18 E1, P11798 ...
http://www.scbt.com/datasheet-9035-camkii-m-176-antibody.htm...

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Abgent - Phosphorylation Antibodies - Phosphorylation
AP7206b, CAMK2A (CAMK2 alpha) Antibody (C-term), WB, IHC, E, H ... AT1375a, CAMK2A monoclonal antibody (M01), ELISA,IF,S-ELISA,WB-Ce,WB-Re,WB-Ti, H ...
http://www.abgent.com/products/category/protein_modification...

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p-CaMKIIα (Thr 286)-R Antibody sc-12886-R
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CAMK2A, 815, 5q33.1, NM_015981, ...
http://www.scbt.com/datasheet-12886-p-camkiialpha-thr-286-an...

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CaMKII antibody (ab19223) | Abcam
CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits. CaMKII is a prominent kinase in the central nervous system that may function in
...
http://www.abcam.com/CaMKII-antibody-ab19223.html...

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CaMKII (H-300) Antibody sc-13082
Human, CAMK2G, 818, 10q22.2, NM_001222, NM_172169, NM_172170, NM_172171, NM_172172, NM_172173 · Q13555 · 602123. Mouse, Camk2a, 12322, 18 E1, P11798 ...
http://www.scbt.com/datasheet-13082-camkii-h-300-antibody.ht...

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