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CDT1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17029205 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18006835 |
hCdt1 and hCdc6 expression promote malignant behavior |
| 17598984 |
we discuss how these dynamic Cdt1-chromatin interactions and the local recruitment of Geminin onto origins of replication by Cdt1 may provide a tight control of the licensing process in time and in space. |
| 15004027 |
Cdt1 is phosphorylated and its degradation induced by Cdk2 and Cdk4 |
| 11896191 |
human CDT1 is essential for DNA replication and chromatin licensing |
| 16261166 |
Cdt1 overexpression contributes to tumorigenecity by causing genomic instability in transgenic p53 knockout mice. |
| 12429841 |
Results show that geminin, cdt1 and cdc6 are differentially regulated during megakaryocytic differentiation and suggest an active role of cdc6 in endomitosis. |
| 16940174 |
Results suggest that DDB1 prevents DNA lesions from accumulating in replicating human cells, in part by regulating Cdt1 degradation. |
| 16273206 |
Cdt1 expression is severely downregulated upon differentiation of Caco-2 cells, an in vitro model of intestinal epithelial differentiation. |
| 17085480 |
DTL promotes genomic stability through two distinct mechanisms. First, it is an essential component of the CUL4-DDB1 complex that controls CDT1 levels, thereby preventing rereplication. Second, it is required for the early G2/M checkpoint. | →View more information from publications. |
Recent Publications on CDT1: |  |
Schizosaccharomyces pombe Noc3 is essential for ribosome biogenesis and cell division but not DNA replication.
The initiation of eukaryotic DNA replication is preceded by the assembly... | 31st October, 2008
| Memorial Sloan-Kettering Cancer Center, Rockefeller Research Laboratories
| Eukaryot Cell. 2008 Sep;7(9):1433-40. Epub 2008 Jul 7.
DOI Direct Link |
The origin recognition complex is dispensable for endoreplication in Drosophila.
The origin recognition complex (ORC) is an essential component of the... | 25th October, 2008
| Department of Molecular Genetics and Microbiology, Duke University Medical
| Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12343-8. Epub 2008 Aug 18.
DOI Direct Link |
Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
The replication factors Cdt1 and Cdc6 are essential for origin licensing,... | 24th October, 2008
| Department of Biochemistry and Biophysics, Curriculum in Genetics and
| J Biol Chem. 2008 Sep 12;283(37):25356-63. Epub 2008 Jul 10.
DOI Direct Link |
Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
Mcm4/6/7 forms a complex possessing DNA helicase activity, suggesting that... | 22nd October, 2008
| Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science,
| J Biol Chem. 2008 Sep 5;283(36):24469-77. Epub 2008 Jul 7.
DOI Direct Link |
The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.
The faithful replication of genomic DNA is crucial for maintaining genome... | 17th October, 2008
| Department of Cellular Biology, University of Georgia, Athens, Georgia
| Genes Dev. 2008 Sep 15;22(18):2507-19.
DOI Direct Link |
→View more research publications. |
CDT1 results (if any) from reagent suppliers | 
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Cdt1 Antibody / Cdt1 Antibodies
Cdt1 Antibody / Cdt1 Antibodies. ... Cdt1 specific siRNA and shRNA gene silencers are also available. These include: Cdt1 siRNA (h): sc-37544. ...
http://www.scbt.com/table-cdt1.html...
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CDT1 antibody (ab70829) datasheet | Abcam
Rabbit polyclonal to CDT1. Geminin is a protein that inhibits DNA replication by preventing the loading of MCM complex on chromatin. Human CDT1 is a 65kDa ...
http://www.abcam.com/index.html?datasheet=70829...
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Cdt1 (H-300) Antibody sc-28262
DDB1 Maintains Genome Integrity through Regulation of Cdt1. Mol. Cell. Biol. ... Western blot analysis of human recombinant Cdt1 fusion protein. Download ...
http://www.scbt.com/datasheet-28262-cdt1-h-300-antibody.html...
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CDT1 Antibody
with the binding of CDT1 and cdc6 to the origin, which. allows binding of the heterohexameric ... Binding of CDT1 to geminin prevents pre-RC formation, and
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http://www.cellsignal.com/pdf/3386.pdf...
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CDT1 Antibody (BL2396)
CDT, CDT1, CDT-1, Chromatin Licensing and DNA Replication Factor 1, DUP, hDUP, human ... CDT1 antibody BL2396 (Cat. No. A300-786A) used for WB at 1 ...
http://www.natutec.de/pdf_bethyl/A300-786A.pdf...
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HPA017224 Anti CDT1 antibody produced in rabbit Prestige ...
HPA017224 Anti-CDT1 antibody produced in rabbit Prestige Antibodies™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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Cdt1 siRNA (h) sc-37544
Recommended Control Antibody (click catalog # for product information). Product Name, Catalog #, Unit, Price, Qty, Wish List. Cdt1 (N-20), sc-18558 ...
http://www.scbt.com/datasheet-37544-cdt1-sirna-h.html...
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CDT1 peptide (ab25718) datasheet | Abcam
CDT1 peptide. Geminin is a protein that inhibits DNA replication by preventing the loading of MCM complex on chromatin. Human CDT1 is a 65kDa protein that ...
http://www.abcam.com/index.html?datasheet=25718...
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CDT1 Blocking Peptide
Anti-CDT1 Antibody, Anti-CDT-1 Antibody, Anti-DUP Antibody, Anti-hDUP. Antibody. Blocking Peptide ... The peptide blocks the ability of anti-CDT1 (Cat. No. ...
https://www.bethyl.com/product/pdf/BP300-786.pdf...
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CDT1 antibodies | Abcam
CDT1 antibodies. ... Trinidad & Tob, Tunisia, Turkey, U.A.E, Ukraine, United Kingdom, United States, Uruguay, Venezuela, Vietnam. We have 1 CDT1 antibodies
...
http://www.abcam.com/index.html?t=92070&pt=1...
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