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MADCAM1


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Gene DB Home
Symbol:MADCAM1
Name(s):mucosal vascular addressin cell adhesion molecule 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:MACAM1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16750586 Observational study of gene-disease association. (HuGE Navigator)
14669317 MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.
15483224 PI3-K/Akt is involved in the gut-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1
11705388 Ca2+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.
11807247 A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1
12100519 more extensive expression of MAdCAM-1 in Crohn's disease (CrD), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD.
15050155 a marker of graft rejection in small intestine transplantation

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD44 antigenmucosal vascular addressin cell adhesion molecule 1 isoform a precursor--Pubmed
HPRDCD44 antigenmucosal vascular addressin cell adhesion molecule 1 isoform a precursor--Pubmed
HPRDCD44 antigen isoform 1 precursormucosal vascular addressin cell adhesion molecule 1 isoform a precursor--Pubmed
HPRDIntegrin alpha 4mucosal vascular addressin cell adhesion molecule 1 isoform a precursor--Pubmed
HPRDintegrin alpha 4 precursorMADCAM1--Pubmed
HPRDintegrin, beta 7mucosal vascular addressin cell adhesion molecule 1 isoform a precursor--Pubmed
HPRDintegrin, beta 7mucosal vascular addressin cell adhesion molecule 1 isoform a precursor--Pubmed

Recent Publications on MADCAM1:

Pubmed Logo
DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells.
The vascular addressins mucosal addressin cell adhesion molecule-1,...
17th September, 2009
Institute of Systemic Inflammation Research, University of Lubeck, Lubeck, Eur J Immunol. 2009 Aug;39(8):2203-14.
DOI Direct Link
Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice.
BACKGROUND & AIMS: Immunoglobulin (Ig) A secretion into the intestinal...
16th September, 2009
Department of Pediatrics, Medical Faculty, RWTH Aachen University, Gastroenterology. 2009 Sep;137(3):924-33. Epub 2009 May 18.
DOI Direct Link
Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin.
Endothelial activation and surface expression of cell adhesion molecules...
26th August, 2009
Department of Medicine, University of Pittsburgh School of Medicine, Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G259-68. Epub
DOI Direct Link
Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation.
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the...
20th August, 2009
Laboratory of Immunogenomics and Proteomics, Department of Immunology, Hum Immunol. 2009 Jun;70(6):457-60. Epub 2009 Mar 12.
DOI Direct Link
GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis.
BACKGROUND: A diffuse lymphocyte infiltrate is 1 of the characteristic...
12th August, 2009
Department of Molecular Pathology, Shinshu University Graduate School of Inflamm Bowel Dis. 2009 May;15(5):697-706.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods
7153963 Phenylalanine derivatives
6939855 Anti-inflammatory compositions and method
6706867 DNA array sequence selection

View more patents.

MADCAM1 results (if any) from reagent suppliers

Google CSE Logo
LEAF Purified Anti-mouse MAdCAM-1 Antibody Anti-MAdCAM-1 - BioLegend
LEAF Purified Anti-mouse MAdCAM-1 Antibody Anti-MAdCAM-1 - MAdCAM-1 is a 58-66kD type I glycoprotein, also known as Mucosal addressin cell adhesion ...
http://www.biolegend.com/leaf-purified-anti-mouse-madcam-1-a...

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MAdCAM-1 (MECA-367) Antibody sc-19604
MAdCAM-1 (MECA-367) Antibody sc-19604 MAdCAM-1 (MECA-367) Antibody sc-19604. ... Western blot analysis of MAdCAM-1 expression in ECV304 whole cell lysate. ...
http://www.scbt.com/datasheet-19604-madcam-1-meca-367-antibo...

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BenderMed Systems: Anti-human MAdCAM-1 Antibody, Monoclonal
Product Name, Anti-human MAdCAM-1 Antibody, Monoclonal. Analyte, MAdCAM-1. Species, Anti-human. Format, Antibody, Monoclonal. Cat. Nr. BMS170 ...
http://www.bendermedsystems.com/products.php?nr=BMS170...

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MAdCAM-1 (W12-1) Antibody sc-80175
MAdCAM-1 shRNA (m) Lentiviral Particles, sc-43038-V, 200 µl ... Western blot analysis of MAdCAM-1 expression in non-transfected: sc-117752 (A) and mouse ...
http://www.scbt.com/datasheet-80175-madcam-1-w12-1-antibody....

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mouse MAdCAM-1 antibody, Fluorescein isothiocyanate (FITC) conjugate
eBioscience technical data sheet for product 11-5997 FITC anti-mouse MAdCAM-1 MECA-367 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_11/11-...

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MadCAM-1 (H-116) Antibody sc-28645
rabbit polyclonal IgG, 200 µg/ml; epitope corresponding to amino acids 291-406 mapping at the C-terminus of MadCAM-1 of human origin; recommended for ...
http://www.scbt.com/datasheet-28645-madcam-1-h-116-antibody....

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MAdCAM1 antibody [MECA-367] (FITC) (ab24941) | Abcam
Rat monoclonal [MECA-367] to MAdCAM1 (FITC). The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with ...
http://www.abcam.com/MAdCAM1-antibody-MECA-367-FITC-ab24941....

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