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NCOA3


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Symbol:NCOA3
Name(s):nuclear receptor coactivator 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, MGC141848, RAC3, SRC-1, SRC3, TNRC14, TNRC16, TRAM-1, pCIP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17805331 MYST3-NCOA3 gene fusions were found in AML-M5. The breakpoint in NCOA3 is at bases 2752 & 2376 in the MYST3-NCOA3 & NCOA3-MYST3 fusion transcripts, respectively. The CREB-interacting domain is conserved.
11056690 Observational study of gene-disease association. (HuGE Navigator)
11092404 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
11161840 Observational study of gene-disease association. (HuGE Navigator)
11927493 Observational study of gene-disease association. (HuGE Navigator)
12602902 Observational study of gene-disease association. (HuGE Navigator)
14557830 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15788663 Observational study of gene-disease association. (HuGE Navigator)
15900600 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15987430 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDandrogen receptor isoform 1nuclear receptor coactivator 3--Pubmed
HPRDandrogen receptor isoform 1nuclear receptor coactivator 3--Pubmed
HPRDCyclin D1nuclear receptor coactivator 3--Pubmed
BINDHomo sapiens chromosome 11, reference assembly.-AIB1 interacts with cyclin D1 promoter.-Pubmed
HPRDbone morphogenetic protein 6 preproproteinnuclear receptor coactivator 3--Pubmed
HPRDbone morphogenetic protein 6 preproproteinnuclear receptor coactivator 3--Pubmed
HPRDbone morphogenetic protein 7 precursornuclear receptor coactivator 3--Pubmed
HPRDbone morphogenetic protein 7 precursornuclear receptor coactivator 3--Pubmed
BINDCREB binding proteinHomo sapiens nuclear receptor coactivator mRNA, complete cds.ACTR interacts with CBP. This interaction was modeled on a demonstrated interaction between human ACTR and CBP from an unspecified species.-Pubmed
HPRDCREB binding proteinnuclear receptor coactivator 3--Pubmed

Recent Publications on NCOA3:

Pubmed Logo
Amplification and expression of EGFR and ERBB2 in Wilms tumor.
Wilms tumor is one of the most common solid tumors in children. We...
9th October, 2009
Department of Pathology, Shiraz Medical School and Shiraz Institute of Cancer Genet Cytogenet. 2009 Oct 15;194(2):88-95.
DOI Direct Link
A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.
Short interfering RNAs (siRNAs) have been used to inhibit HIV-1...
26th September, 2009
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, J Biol Chem. 2009 Jul 17;284(29):19463-73. Epub 2009 May 20.
DOI Direct Link
Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
We systematically investigated the association of 48 SNPS in four vitamin...
21st May, 2009
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Carcinogenesis. 2009 May;30(5):769-76. Epub 2009 Mar 2.
DOI Direct Link
Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder.
Urothelial carcinoma (UC) of the bladder is approximately three times more...
12th May, 2009
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA. Endocr Relat Cancer. 2009 Mar;16(1):123-37. Epub 2008 Oct 9.
DOI Direct Link
The role of SRC-1 in murine prostate cancinogenesis is nonessential due to a possible compensation of SRC-3/AIB1 overexpression.
The androgen and androgen receptor (AR)-regulated gene expression plays...
16th April, 2009
1. Department of Molecular and Cellular Biology, Baylor College of Int J Biol Sci. 2009;5(3):256-64. Epub 2009 Mar 14.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7381526 Assays for drug discovery based on microcompetition with a foreign polynucleotide
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7063947 System for producing synthetic promoters
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

View more patents.

NCOA3 results (if any) from reagent suppliers

Google CSE Logo
Purified Anti-NCOA3/SRC3 Antibody - BioLegend
Purified Anti-NCOA3/SRC3 Antibody - NCOA3/SRC3 (nuclear receptor coactivator 3/ steroid receptor coactivator 3 (SRC3)) is a 155 kD member of the p160/steroid
...
http://www.biolegend.com/purified-anti-ncoa3-src3-antibody-2...

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NCoA-3 (H-80) Antibody sc-25742
See how others have used NCoA-3 (H-80): sc-25742 antibody and or NCoA-3 (H-80) ... Western blot analysis of NCoA-3 expression in HeLa whole cell lysate. ...
http://www.scbt.com/datasheet-25742-ncoa-3-h-80-antibody.htm...

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ORDERING INFORMATION
Nuclear Receptor Coactivator 3 (NCOA3) functions in the multisubunit coactivator complex. Multiple nuclear hormone receptors are able to bind to NCOA3 in a ...
http://www.rndsystems.com/pdf/AF5076.pdf...

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NCoA-3 (C-20) Antibody sc-7216
See how others have used NCoA-3 (C-20): sc-7216 antibody and or NCoA-3 (C-20) ... Western blot analysis of NCoA-3 expression in HeLa nuclear extract. ...
http://www.scbt.com/datasheet-7216-ncoa-3-c-20-antibody.html...

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KAT13B / AIB1 antibody [0.T.198] (ab14139) | Abcam
Immunohistochemistry (Paraffin-embedded sections) - NCOA3 antibody [0. ... Fusion protein, corresponding to amino acids 605-1294 of Human NCOA3. Reacts
with ...
http://www.abcam.com/KAT13B-AIB1-antibody-0-T-198-ab14139.ht...

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NCoA-3 (N-17) Antibody sc-7217
NCoA-3 shRNA (h) Lentiviral Particles, sc-29636-V, 200 µl ... See how others have used NCoA-3 (N-17): sc-7217 antibody and or NCoA-3 (N-17) antibody ...
http://www.scbt.com/datasheet-7217-ncoa-3-n-17-antibody.html...

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Purified Anti-CBP Antibody - BioLegend
This 265 kD acetyltransferase enzyme, acetylates histones and non-histone proteins like NCOA3 coactivator and ... Purified anti-NCOA3/SRC3, Poly6092, WB
...
http://www.biolegend.com/purified-anti-cbp-antibody-2070.htm...

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