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CANX


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Gene DB Home
Symbol:CANX
Name(s):calnexin
Type:protein-coding
Organism:Homo sapiens
Synonyms:CNX, FLJ26570, IP90, P90
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17728248 Endoplasmic reticulum chaperones stabilize nicotinic receptor subunits and regulate receptor assembly.
17395585 D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin
12610305 EDEM appeared to function in the ERAD (endoplasmic reticulum-associated degradation)pathway by accepting substrates from calnexin.
12610306 EDEM was shown to extract misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle
17170088 proportion of the human and the rat WT gonadotropin-releasing hormone receptor appears to be retained in the endoplasmic reticulum by calnexin, an effect that decreases GnRHR signaling capacity
15923638 Data show that the major degradation pathway of the cystic fibrosis transmembrane conductance regulator with F508 deletion from the endoplasmic reticulum is independent of calnexin.
12805210 Data show that calnexin associates with newly synthesized proteolipid protein (PLP) molecules, binding stably to misfolded PLP.
15537650 results support emerging models for a glycan-independent chaperone role for calnexin and for the mechanism of retention of misfolded membrane proteins in the endoplasmic reticulum
12239218 Data show that CD1d associates in the ER with both calnexin and calreticulin and with the thiol oxidoreductase ERp57 in a manner dependent on glucose trimming of its N-linked glycans.
15161937 Calnexin provides long-term protection of wild-type Shaker protein from ER-associated degradation.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCalnexincoagulation factor VIII isoform a precursor--Pubmed
HPRDCalnexinintegrin alpha chain, alpha 6--Pubmed
HPRDCalnexinthyroid stimulating hormone receptor--Pubmed
HPRDCalnexinATP-binding cassette, sub-family C, member 2--Pubmed
HPRDCalnexinCD3D antigen, delta polypeptide isoform A precursor--Pubmed
HPRDCalnexinglutamate receptor, ionotropic, AMPA 1--Pubmed
HPRDCalnexin5-hydroxytryptamine receptor 3A isoform b precursor--Pubmed
HPRDCalnexinCD1D antigen precursor--Pubmed
HPRDCalnexinlactase-phlorizin hydrolase preproprotein--Pubmed
HPRDCalnexinlow density lipoprotein-related protein 1--Pubmed

Recent Publications on CANX:

Pubmed Logo
Testicular gene expression in male mice divergent for fertility after heat stress.
Fertility losses in male mice occur approximately 18-28 d after heat...
29th May, 2009
Department of Animal Sciences, University of Wyoming, Laramie, WY, United Theriogenology. 2009 Mar 1;71(4):651-61. Epub 2008 Nov 6.
DOI Direct Link
Normalizing gene expression levels in mouse fetal germ cells.
Real-time PCR has become a popular method to analyze transcription of...
1st May, 2009
Department of Paediatrics, Murdoch Children's Research Institute, Biol Reprod. 2009 Aug;81(2):362-70. Epub 2009 Apr 29.
DOI Direct Link
Housekeeping gene expression is affected by antidepressant treatment in a mouse fibroblast cell line.
AbstractQuantitative real-time polymerase chain reaction (PCR) is an...
17th December, 2008
MRC Social Genetic and Developmental Psychiatry (SGDP) Centre, Institute J Psychopharmacol. 2008 Dec 12.
DOI Direct Link
PSMB2 and RPL32 are suitable denominators to normalize gene expression profiles in bronchoalveolar cells.
BACKGROUND: For accuracy of quantitative reverse transcriptase-polymerase...
11th November, 2008
Department of Immunology, Palacky University, The Czech Republic. BMC Mol Biol. 2008 Jul 31;9:69.
DOI Direct Link
Endoplasmic reticulum stress response in murine kidney exposed to acute hypobaric hypoxia.
Any perturbation in the normal functioning of endoplasmic reticulum (ER),...
16th September, 2008
Institute of Genomics and Integrative Biology, Mall Road, Delhi, India. FEBS Lett. 2008 Jul 23;582(17):2521-6. Epub 2008 Jun 20.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7599933 Coupled two-way clustering analysis of data
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6963383 Electrode substrate and production method thereof
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6828045 Organic electroluminescence element and production method thereof

View more patents.

CANX results (if any) from reagent suppliers

Google CSE Logo
C4731 Anti-Calnexin antibody produced in rabbit IgG fraction of ...
microarray: suitable. Gene Information, human ... CANX(821). rat ... Canx(29144) . mouse ... Canx(12330). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Calnexin (H-70) Antibody sc-11397
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CANX, 821, 5q35.3, NM_001024649, ...
http://www.scbt.com/datasheet-11397-calnexin-h-70-antibody.h...

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Antibodies to ER and Golgi Proteins
rat ... Canx(29144), human, mouse, rat, canine, ARR, IF (i), IP, WB, pricing .... human ... CANX(821), human, ELISA (i), FACS, ICC, IHC, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Baculo-EZ Expression Ready Clones
calnexin-His6 (CANX), BVC-10065, $395.00. carboxypeptidase E (Cpe), BVC-10056, $395.00. Carboxypeptidase E delta-23 (Cpe), BVC-10057, $395.00 ...
http://www.orbigen.com/dictionary/cat1068.htm...

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