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CAPN1

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Symbol:	CAPN1
Name(s):	calpain 1, (mu/I) large subunit
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	CANP, CANP1, CANPL1, muCANP, muCL
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18070881	calpain 1 N-terminus is a mitochondrial targeting sequence
17977825	Calpain emerges as a central player in E7-mediated degradation of Rb
18085799	Protein adducts of iso[4]levuglandin E2 (iso[4]LGE2), a highly reactive product of free radical-induced lipid oxidation, accumulate in human glaucomatous trabecular meshwork (TM) but not in controls.
18165173	The activity of calpain in human peripheral blood lymphocytes, was estimated by assessing the levels of limited proteolysis of calpastatin.
18032503	both calpain 1 and calpain 2 are essential for the replication of EV1 RNA.
18071073	platelets from patients with type 2 diabetes mellitus, were found to have enhanced tyrosine nitration and inactivation of the sarcoplasmic endoplasmic reticulum Ca2+-ATPase (SERCA-2), elevated platelet [Ca2+]i, and activation of mu-calpain.
17195093	Results suggest that calpains are involved in hypoxia-induced necrotic cell death, and that the inhibition of calpain switches hypoxia-induced cell death to apoptotic cell death without affecting cell viability.
17908236	In patients with Alzheimer disease, over-activation of calpain because of calcium dysregulation causes increased degradation and thus decreased activity of PKA, which, in turn, contributes to down-regulation of CREB and impaired cognition and memory.
17765980	Taken together, these results suggested calpain involvement in Th1/Th2 dysregulation in MS patients.
17690304	Nitric oxide-induced motility in osteoclasts requires regulated Ca(2+) release, which activates mu-calpain. This occurs via the Ins(1,4,5)P(3)R1.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	cardiac muscle alpha actin 1 proprotein	calpain 1, large subunit	CAPN1 interacts with ACTC.	-	Pubmed
BIND	actinin, alpha 2	calpain 1, large subunit	CAPN1 interacts with ACTN2.	-	Pubmed
HPRD	BH3 interacting domain death agonist isoform 2	calpain 1, large subunit	-	-	Pubmed
HPRD	BH3 interacting domain death agonist isoform 2	calpain 1, large subunit	-	-	Pubmed
HPRD	Calpain, large polypeptide L1	INPP4A protein	-	-	Pubmed
HPRD	Calpain, large polypeptide L1	kininogen 1 isoform 2	-	-	Pubmed
HPRD	calpain 1, large subunit	Kininogen	-	-	Pubmed
HPRD	calpain 1, large subunit	Inositol polyphosphate 4 phosphatase type1, 107 kD	-	-	Pubmed
BIND	calpain 1, large subunit	alpha 1 type I collagen preproprotein	CAPN1 interacts with COL1A1.	-	Pubmed
BIND	calpain 1, large subunit	collagen, type III, alpha 1 preproprotein	CAPN1 interacts with COL3A1.	-	Pubmed

Recent Publications on CAPN1:
Effect of single nucleotide polymorphisms of CAPN1 and CAST genes on meat traits in Nellore beef cattle (Bos indicus) and in their crosses with Bos taurus. The objectives of this work were to study the segregation of single...	23rd October, 2009	Departamento de Melhoramento e Nutricao Animal, Faculdade de Medicina	Anim Genet. 2009 Aug;40(4):456-62. Epub 2009 Mar 18. DOI Direct Link
New single nucleotide polymorphisms in the mu-calpain gene in Spanish maternal beef breeds. Calpains play an important role in the postmortem tenderization process of...	3rd October, 2009	MERAGEM Research Group. Department of Genetics, Faculty of Veterinary	Anim Biotechnol. 2009;20(3):161-4. DOI Direct Link
Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases. Mechanically damaged plasma membrane undergoes rapid calcium-dependent...	29th September, 2009	Department of Physiology and Pharmacology, University of Toledo College of	Biochim Biophys Acta. 2009 Sep 23. DOI Direct Link
Calpain-1 is required for hydrogen peroxide-induced myotube atrophy. Recent reports suggest numerous roles for cysteine proteases in the...	18th August, 2009	Dept. of Applied Physiology and Kinesiology, Univ. of Florida, Rm. 25	Am J Physiol Cell Physiol. 2009 Feb;296(2):C363-71. Epub 2008 Dec 24. DOI Direct Link
Wnt5A activates the calpain-mediated cleavage of filamin A. We have previously shown that Wnt5A and ROR2, an orphan tyrosine kinase...	21st July, 2009	Laboratory of Immunology, National Institute on Aging, National Institutes	J Invest Dermatol. 2009 Jul;129(7):1782-9. Epub 2009 Jan 29. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
7598031	Method for the detection of gene transcripts in blood and uses thereof
6706867	DNA array sequence selection
6753314	Protein-protein complexes and methods of using same
7208313	Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7238479	Single nucleotide polymorphism markers in the bovine CAPN1 gene to identify meat tenderness
→View more patents.

CAPN1 results (if any) from reagent suppliers

Antibodies to Calcium-Associated Proteins CAPN1(823) rat ... Capn1(29153), pig, bovine, human, rat, IF (i), WB, pricing ... rat ... Capn1(29153), bovine, rat, human, pig, IF (i), WB, pricing ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
Calpain 1 (H-65) Antibody sc-13990 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CAPN1, 823, 11q13.1, NM_005186 ... http://www.scbt.com/datasheet-13990-calpain-1-h-65-antibody....
PTPRN antibody, Receptor-type tyrosine-protein phosphatase-like N ... Subunit: Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the ... http://www.genwaybio.com/product_info.php?products_id=237...
Product Data Sheet 22 Nov 2004 ... (CAPN1 for µ-calpain and CAPN2 for m-calpain) and exhibit distinct calcium ion requirements. m-Calpain requires millimolar levels of Ca2+, ... http://www.biomol.com/SiteData/docs/productdata/CG1920.pdf...
157635 7,7,8,8-Tetracyanoquinodimethane TCNQ 98% assay, 98%. mp, 287-289 °C (dec.)(lit.) Gene Information, human ... CAPN1(823). rat ... Capn1(29153), Nos1(24598). Safety ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=1576...
Calpain 1 (15C10) Antibody sc-58323 种属, 基因名称, 基因ID, 染色质位置, 亚型（mRNA）即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, CAPN1, 823, 11q13.1, NM_005186 · P07384 ... http://www.scbt.com/zh/datasheet-58323-calpain-1-15c10-antib...
W218405 Butylated hydroxytoluene BHT, DBPC ≥99%, FCC, Kosher assay, ≥99%. autoignition temp. 878 °F. bp, 265 °C(lit.) mp, 69-73 °C(lit.) Gene Information, human ... CAPN1(823). rat ... Capn1(29153), Nos1(24598) ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en...

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CAPN1

Gene Information from Publications

Interacting gene products

Recent Publications on CAPN1:

Patents:

CAPN1 results (if any) from reagent suppliers