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JARID1C
| Symbol: | JARID1C | | Name(s): | jumonji, AT rich interactive domain 1C | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DXS1272E, KDM5C, MRXJ, MRXSJ, SMCX, XE169 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18078810 |
Thus, SMCX is a novel Smad3 corepressor that may antagonize the tumor suppressing activity of the TGF-beta/Smad3 signaling pathway and thereby contribute to tumorigenesis. |
| 17468742 |
has H3K4 tri-demethylase activity; functions as transcriptional repressor; loss of JARID1C/SMCX activity impairs REST-mediated neuronal gene regulation, thereby contributing to SMCX-associated X-linked mental retardation |
| 16538222 |
JARID1C may have a role in X-Linked Mental Retardation |
| 16541399 |
JARID1C appears to be one of the more frequently mutated genes in X-linked mental retardation. |
| 17320160 |
We show that the X-linked mental retardation gene SMCX, which encodes a JmjC-domain protein, reversed histone H3 lysine 4 to di- and mono- but not unmethylated products. |
Recent Publications on JARID1C: |  |
To be or NOT to be demethylated.
Xist non-coding RNA (ncRNA) is essential for X chromosome inactivation... | 21st October, 2009
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| Cell Cycle. 2009 Jul 15;8(14):2135-7. Epub 2009 Jul 20.
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Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation.
Mental retardation (MR) is characterized by cognitive impairment with an... | 15th October, 2009
| [1] Department of Pathology, Faculty of Medicine, Prince of Songkla
| Eur J Hum Genet. 2009 Oct 14.
DOI Direct Link |
Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein.
We have assigned 1H, 13C and 15N resonances of the Bright/ARID DNA-binding... | 27th August, 2009
| Leibniz-Institut fur Molekulare Pharmakologie (FMP), Robert-Rossle-Str.
| Biomol NMR Assign. 2008 Jun;2(1):9-11. Epub 2007 Dec 8.
DOI Direct Link |
Identification of the chromatin regions coated by non-coding Xist RNA.
Xist non-coding RNA (ncRNA) is essential for X chromosome inactivation... | 31st July, 2009
| Department of Biomedical Science, Regenerative Medicine and Biofunction,
| Cytogenet Genome Res. 2009;125(1):19-25. Epub 2009 Jul 14.
DOI Direct Link |
Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression.
The identification of histone methyltransferases and demethylases has... | 28th April, 2009
| Department of Biochemistry, Purdue University, West Lafayette, Indiana
| Genes Dev. 2009 Apr 15;23(8):951-62. Epub 2009 Apr 3.
DOI Direct Link |
→View more research publications. |
JARID1C results (if any) from reagent suppliers | 
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KDM5C / Jarid1C / SMCX antibody (ab34718) | Abcam
Rabbit polyclonal to KDM5C / Jarid1C / SMCX. KDM5C / JARID1C / SMCX is expressed in a variety of tissues and it's highest levels are found in skeletal and ...
http://www.abcam.com/KDM5C-Jarid1C-SMCX-antibody-ab34718.htm...
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JARID1B Antibody #3273
JARID1C has been found in a complex with HDAC1, HDAC2, G9a and REST, ... JARID1C mutations are associated with X-linked mental retardation and epilepsy (15 ...
http://www.cellsignal.com/products/3273.html...
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KDM5C / Jarid1C / SMCX antibodies: Chromatin and Nuclear Signaling ...
KDM5C / Jarid1C / SMCX antibodies. ... KDM5C / Jarid1C / SMCX antibody. IP, WB. Images. Rabbit polyclonal. Reacts with: Hu. Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=152678&pt=1&c=3423&ei=&mu=...
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JARID1B Antibody
and RBBP2), JARID1B (also PLU-1), JARID1C (also SMCX) and JARID1D (also SMCY) (4 ). ... JARID1C mutations are associated with X-linked ...
http://www.cellsignal.com/pdf/3273.pdf...
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JMJD2A Antibody Bethyl Laboratories
Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. ...
http://www.bethyl.com/go/?product/A300-861A/TreeKey=f6f398b3...
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JARID1A (D28B10) XP™ Rabbit mAb
(also RBP2 and RBBP2), JARID1B (also PLU-1), JARID1C ... JARID1C mutations are associated with. X-linked mental retardation and epilepsy (15,16). JARID1D ...
http://www.cellsignal.com/pdf/3876.pdf...
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Histone demethylation | Abcam
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 128, 1077-1088. Klose, R. J., Kallin, E. M., ...
http://www.abcam.com/index.html?pageconfig=resource&rid=1118...
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