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CASP1

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Symbol:	CASP1
Name(s):	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	ICE, IL1BC, P45
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18304957	Observational study of gene-disease association. (HuGE Navigator)
18329368	Study shows that secretion of the leaderless proteins proIL-1alpha, caspase-1, and fibroblast growth factor (FGF)-2 depends on caspase-1 activity.
18209072	Triggering of cytosolic RNA recognition pathway with poly(I:C) transfection or influenza A virus infection resulted in caspase-1- and -3-mediated proteolytic processing of pro-IL-18 and secretion of biologically active IL-18.
16778130	Observational study of gene-disease association. (HuGE Navigator)
17477815	Observational study of gene-disease association. (HuGE Navigator)
17959595	characterization of caspase-1 substrates identifies the glycolysis pathway as a caspase-1 target and provides new insights into its function during pyroptosis and septic shock.
17597823	the activity of caspase-1 is increased in psoriatic skin and IL-18 secretion is regulated by a p38 MAPK/caspase-1-dependent mechanism
17623017	identification of a novel function of HIPPI; it binds to specific upstream sequences of the caspase-1, caspase-8 and caspase-10 genes and alters the expression of the genes
16817903	Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis
12692130	Caspases responsible for parkin cleavage were identified by several experimental paradigms exploring the anti-Fas induced pathway and tnf-alpha pathway.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	androgen receptor isoform 1	caspase 1 isoform alpha precursor	Androgen Receptor interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 1 from an unspecified species.	-	Pubmed
HPRD	Caspase 1	epidermal growth factor receptor oncogene homolog, avian)	-	-	Pubmed
HPRD	Caspase 1	nucleotide-binding oligomerization domain containing 1	-	-	Pubmed
HPRD	Caspase 1	caspase 14 precursor	-	-	Pubmed
BIND	-	caspase recruitment domain family, member 8	CARD-8 interacts with Casp-1	-	Pubmed
HPRD	Caspase 1	caspase recruitment domain protein 12	-	-	Pubmed
BIND	-	caspase recruitment domain protein 12	CARD12 (CLAN) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD12 and CASP1 from an unspecified species.	-	Pubmed
BIND	-	nucleotide-binding oligomerization domain containing 2	CARD15 (Nod2) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human CARD15 and CASP1 from an unspecified species.	-	Pubmed
BIND	-	NLR family, pyrin domain containing 1 isoform 1	NALP1 (NAC) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human NALP1 and CASP1 from an unspecified species.	-	Pubmed
HPRD	caspase 1 isoform alpha precursor	Caspase 14	-	-	Pubmed

Recent Publications on CASP1:
An analysis of growth, differentiation and apoptosis genes with risk of renal cancer. We conducted a case-control study of renal cancer (987 cases and 1298...	23rd October, 2009	Division of Cancer Epidemiology and Genetics, National Cancer Institute,	PLoS One. 2009 Mar 24;4(3):e4895. DOI Direct Link
Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Curcumin, a natural product isolated from the plant Curcuma longa, has a...	24th September, 2009	Laboratoire de Biologie Moleculaire et Cellulaire du Cancer, Hopital	Ann N Y Acad Sci. 2009 Aug;1171:436-47. DOI Direct Link
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. The therapeutic efficacy of anticancer chemotherapies may depend on...	22nd September, 2009	Institut National de la Sante et de la Recherche Medicale, U805,	Nat Med. 2009 Oct;15(10):1170-8. Epub 2009 Sep 20. DOI Direct Link
Febrile seizures: characterization of double-stranded RNA-induced gene expression. An association has long been suspected between febrile seizures and...	22nd September, 2009	Department of Pediatrics, Faculty of Medicine, Saga University, Saga,	Pediatr Neurol. 2009 Aug;41(2):114-8. DOI Direct Link
Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies. Caspases play a critical role in regulation of apoptosis, cell...	28th July, 2009	Division of Cancer Epidemiology and Genetics, National Cancer Institute,	Blood. 2009 Jul 9;114(2):264-7. Epub 2009 May 4. DOI Direct Link
→View more research publications.

BioNews Results for CASP1 :
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1EUR'dependent adaptive immunity against t	Nature: Oct 9 2009 3:46PM Matching: casp1

Patents:
US Patent No.	Title
7612181	Dual variable domain immunoglobulin and uses thereof
7208313	Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7067712	Caspase 1 gene transfer animal
7052834	Tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein
7026121	Methods and compositions for diagnosing and monitoring transplant rejection
→View more patents.

CASP1 results (if any) from reagent suppliers

Caspase-1 Antibody (CT) a caspase in the inflammatory subfamily Casp-1 antibody can be used for the detection of Caspase-1 by Western blot at 0.5 ug/ml or Immunohistochemistry. Depending on cell lines or tissues used, ... http://www.prosci-inc.com/shop/catalog1/Caspase-1-Antibody-p...
C4851 Anti-Caspase 1 (ICE) antibody produced in rabbit IgG ... Gene Information, human ... CASP1(834). rat ... Casp1(25166). mouse ... Casp1( 12362). shipped in, dry ice. storage temp. −20°C ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
Abgent Antibodies and Peptides AP6708b, Myoglobin Antibody (C-term), WB, E, H, M, 2009-10-13. AP6703c, CASP1 Antibody (Center), WB, E, H, 2009-10-13. AP6706c, SERPIND1 Antibody (Center) ... http://www.abgent.com/products/new_release...
IMG-804 (Caspase 1) 0204.qxp IMG-804-4 anti-Casp-1 monoclonal antibody* (0.5 mg/ml). ... A schematic map of GeneSuppressor Caspase-1 (Casp-1) plasmid DNA. ... http://www.imgenex.com/get_details.php?catalog_no=IMG-804...
Abgent - Apoptosis Antibodies AP6703cNEW, CASP1 Antibody (Center), WB, E, H. AT1400a, CASP1 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Re, H. AP1326bNEW, CASP10 Antibody (C- term) ... http://www.abgent.com/products/category/apoptosis...
Caspase-4 Antibody CASP1 CASP4CASP5. 200. 140. 100. 80. 60. 50. 40. 30. 20. 10. Western blot analysis of extracts from KARPAS-299, THP-1 and ... http://www.cellsignal.com/pdf/4450.pdf...
caspase-1 p10 (M-20) Antibody sc-514 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Casp1, 12362, 9 A1, P29452 ... http://www.scbt.com/datasheet-514-caspase-1-p10-m-20-antibod...

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CASP1

Gene Information from Publications

Interacting gene products

Recent Publications on CASP1:

BioNews Results for CASP1

Patents:

CASP1 results (if any) from reagent suppliers