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APH1B
| Symbol: | APH1B | | Name(s): | anterior pharynx defective 1 homolog B (C. elegans) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | APH-1B, DKFZp564D0372, PRO1328, PSFL, TAAV688 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17466415 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 15629423 |
knock down of APH-1a, but not APH-1b, resulted in impaired maturation of nicastrin and reduced expression of presenilin 1, presenilin 2, and PEN-2 proteins |
| 15823552 |
APH-1b variant protein is destabilized, and the fourth transmembrane domain plays an important role in the protein stability and function of APH-1. |
| 16757808 |
These results collectively indicate that the three forms of APH-1 can replace each other in presenilin (PS) complexes and that the transmembrane GxxxG region is essential for the stability of the APH-1 protein as well as the assembly of PS complexes. |
| 12763021 |
Expression of APH-1b increases amyloid beta peptide levels and gamma-secretase activity. |
| 15286082 |
both APH-1a splice forms and APH-1b are expressed in peripheral and neuronal cells. APH-1aS, APH-1aL, and APH-1b form separate, proteolytically active gamma-secretase complexes containing either one of the two presenilins. |
| 15591316 |
dimeric (NCSTN/APH-1) and trimeric (NCSTN/APH-1/PS1) intermediates of gamma-secretase complex assembly are retained within the ER and incorporation of the fourth binding partner (PEN-2) also occurs on immature NCSTN (APH-1) |
APH1B results (if any) from reagent suppliers | 
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Aph 1b antibody (ab24613) | Abcam
This antibody reacts with Aph-1b, and also shows some cross reactivity with ... This antibody recognizes a sequence in the Aph-1b C-Terminal Region. ...
http://www.abcam.com/aph-1b-antibody-ab24613.html...
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Aph-1b siRNA (h) sc-60190
Click here for details. suitable control antibody: Aph-1b (C-13): sc-49358; sqRT -PCR Primer also available: Aph-1b (h)-PR: sc-60190-PR, 20 µl ...
http://www.scbt.com/datasheet-60190-aph-1b-sirna-h.html...
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Aph 1b antibody (ab24614) | Abcam
See below for Aph 1b antibody images, references, products related to ab24614 and other ... Contact Abcam with a Technical Enquiry about Aph 1b antibody ...
http://www.abcam.com/aph-1b-antibody-ab24614.html...
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Anti-Aph-1aL antibody produced in rabbit (A9603) - Datasheet
1aL and is not found in Aph-1aS and Aph-1b. The antibody is affinity-purified using the immunizing ... and Aph-1b (258 amino acids), containing seven ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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Aph Antibody / Aph Antibodies
Aph-1b (C-13) Antibody, sc-49358, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h. Aph-1b (N-12) Antibody, sc-49359, goat IgG, N-terminus (h), WB, IF, ...
http://www.scbt.com/ko/table-aph.html...
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Discounted Parkinson's antibodies | Abcam
... SNAP25 antibody (ab41726) · Aph 1b [c-terminal] antibody (ab24613); Aph 1b [ loop region] antibody (ab24614) · DNM1L antibody (ab54038) ...
http://www.abcam.com/index.html?pageconfig=resource&rid=1162...
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Aph-1b (C-13) Antibody sc-49358
Aph-1b (C-13) Anticorps sc-49358 Aph-1b (C-13) Antibody sc-49358.
http://www.scbt.com/fr/datasheet-49358-aph-1b-c-13-antibody....
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