|
| |
CASP2
| Symbol: | CASP2 | | Name(s): | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
|
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18238895 |
p53-mediated apoptosis occurs by a PIDD- and caspase 2-dependent mechanism, and p53's full transcriptional regulatory functions may be required only for events that are downstream of cytochrome c release |
| 18166155 |
control of caspase-2 exon 9 inclusion by topoisomerase inhibitors depends on phosphorylation and/or dephosphorylation events, and on the cell cycle phase |
| 17637755 |
PIDD isoforms are capable of activating nuclear factor-kappaB in response to genotoxic stress, but only isoform 1 interacts with RIP-associated ICH-1/CED-3 homologous protein with a death domain and activates caspase-2. |
| 17945178 |
Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation. |
| 17627033 |
Data suggest that caspase 2-mediated programmed cell death participates in the seizure-induced degenerative process in experimental and human TLE. |
| 15173176 |
caspase-2 has a role in cleavage of Bid |
| 12065594 |
acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis |
| 11823470 |
role in cytochrome C release and apoptosis from the nucleus |
| 16172118 |
proteolytic activation of Bid and the subsequent induction of the mitochondrial apoptotic pathway through Bax/Bak is essential for apoptosis triggered by caspase-2 |
| 15262979 |
caspase-2 and caspase-8 activation have roles in the mitochondrial apoptotic pathway induced by ceramide or etoposide | →View more information from publications. |
Recent Publications on CASP2: |  |
Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).
Tetraiodothyroacetic acid (tetrac) inhibits the cellular actions of... | 20th October, 2009
| Ordway Research Institute, Albany College of Pharmacy, Albany, NY, USA.
| Cell Cycle. 2009 Nov 1;8(21).
|
Analysis of the mouse high-growth region in pigs.
In the mouse, homozygous animals for the high growth mutation show a... | 22nd September, 2009
| Department of Animal Science, Center for Integrated Animal Genomics, Iowa
| J Anim Breed Genet. 2009 Oct;126(5):404-12.
DOI Direct Link |
Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells.
Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr... | 26th August, 2009
| Department of Rheumatology and Clinical Pharmacology, 2nd Internal Clinic,
| Cancer Invest. 2009 Aug;27(7):704-17.
DOI Direct Link |
Intrinsic pathway of apoptosis in peripheral blood eosinophils of Churg-Strauss syndrome.
OBJECTIVES: Churg-Strauss syndrome (CSS) is a rare necrotizing vasculitis... | 1st August, 2009
| Department of Medicine, Jagiellonian University Medical College, ul.
| Rheumatology (Oxford). 2009 Oct;48(10):1202-7. Epub 2009 Jul 29.
DOI Direct Link |
Therapeutic activities of intravenous immunoglobulins in multiple sclerosis involve modulation of chemokine expression.
The objective of this study was to identify genes that are differentially... | 23rd June, 2009
| BMT-Research GmbH, Vienna, Austria.
| J Neuroimmunol. 2009 Apr 30;209(1-2):114-20. Epub 2009 Feb 13.
DOI Direct Link |
→View more research publications. |
CASP2 results (if any) from reagent suppliers | 
|
Caspase-2 Antibody (NT) a caspase induced by ER stress and DNA damage
Murine Casp-2 / ICH-1 / Nedd2 (N-Terminus) Peptide (Cat. No. 3447P) ... Blocking Peptide. Cat. No. 3447P - Casp-2 Peptide ...
http://www.prosci-inc.com/shop/catalog1/Caspase-2-Antibody-p...
|
 |
caspase-2 (H-19) Antibody sc-623
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CASP2, 835, 7q34, NM_032982, ...
http://www.scbt.com/datasheet-623-caspase-2-h-19-antibody.ht...
|
 |
Abgent - Apoptosis Antibodies
AT1403a, CASP14 monoclonal antibody (M01), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H. AP1327cNEW, CASP2 Antibody (Center), WB, E, H ...
http://www.abgent.com/products/category/apoptosis...
|
 |
Apoptosis and Autophagy
Casp-2. Casp-3,-6,-7. Casp-9. NIK. RIP1. RIP1. Traf2. TAK1. ASK1. Bid. NF- B. NF - B. NF- B. I B. I B. IKK. IKK. IKK. FoxO1. FoxO1 p53 p53 p53 p53 c-Jun ...
http://www.cellsignal.com/about/marketing/pdfs/apop_1008.pdf...
|
 |
Caspase detection protocol | Abcam
Initiator caspases (e.g. CASP1, CASP2, CASP8, CASP9, CASP10, CASP12) cleave inactive pro-forms of effector caspases, thereby activating them. ...
http://www.abcam.com/index.html?pageconfig=resource&rid=1137...
|
 |
Primary Antibodies - GenWay Biotech Inc.
Affinity Purified anti-Caspase-2 [Rabbit]; CASP-2; EC 3.4.22.55; ICH-1 protease; Neural precursor cell expressed developmentally down-regulated protein 2; ...
https://www.genwaybio.com/all_primary_antibodies.php?sort=2a...
|
 |
Tumor Necrosis Factor (TNF)
CASP2 · IKBKG · MAPK3 · SUMO1 · CASP3 · LMNA · MAPK7 · TANK · CASP6 · LMNB1 · MAPK8 (JNK1), TNFRSF11A · CASP7 · LMNB2 · MAPK11 · TRADD ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...
|
 |
Search Bioportfolio and other Life Science Sites for CASP2,
or search for CASP2 on BioPortfolio's antibody search engine.
This page has been viewed 586 times
Recent Search Terms used to find this page: casp2 | casp-2 chromosome location | caspase-2 isoform | caspase 2 2009 | caspase-2 nuclear apoptosis | caspase-2 ICH-1 | caspase-2 and disease | caspase 2 isoform 1 preproprotein | caspases 2009 | .
Resources from the NCBI used on this page, NCBI's standard disclaimer applies.
|
