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CASP3


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Symbol:CASP3
Name(s):caspase 3, apoptosis-related cysteine peptidase
Type:protein-coding
Organism:Homo sapiens
Synonyms:CPP32, CPP32B, SCA-1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17989718 constitutively and overexpressed AML1-ETO protein was cleaved to four fragments of 70, 49, 40 and 25 kDa by activated caspase-3 during apoptosis induction by extrinsic mitochondrial and death receptor signaling pathways.
18211414 The low frequency of apoptotic phenomena (caspase-3 and Bax) in epithelial cells of oral lichen planus may create a favourable substrate for malignant transformation.
18209072 Triggering of cytosolic RNA recognition pathway with poly(I:C) transfection or influenza A virus infection resulted in caspase-1- and -3-mediated proteolytic processing of pro-IL-18 and secretion of biologically active IL-18.
18164959 caspase-3 activation by RSVL is required for PARP degradation and induction of apoptosis
18256758 Sharp inhibition of apoptosis and changes in the levels of cell proliferation in tumor cells were paralleled by decreased expression of peripheral benzodiazepine receptor in patients with squamous cell carcinoma & skin melanoma.
17071630 Observational study of gene-disease association. (HuGE Navigator)
17534194 Observational study of gene-disease association. (HuGE Navigator)
18058802 Observational study of gene-disease association. (HuGE Navigator)
18171980 The basal caspase activity is accompanied by a constant cleavage of the motility-associated gelsolin protein, which may contribute to the caspase-mediated promotion of migration and invasiveness in glioblastoma cells
18155731 The experiments revealed that N induces the intrinsic apoptotic pathway, resulting in processing of N at residues 400 and 403 by caspase-6 and/or caspase-3.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDpoly polymerase family, member 1caspase 3 preproproteinPARP interacts with Caspase-3. This interaction was modeled on a demonstrated interaction between human PARP and caspase-3 from an unspecified source.-Pubmed
HPRDHIAP2caspase 3 preproprotein--Pubmed
HPRDbaculoviral IAP repeat-containing protein 2Caspase 3--Pubmed
HPRDBaculoviral IAP repeat containing protein 3caspase 3 preproprotein--Pubmed
HPRDbaculoviral IAP repeat-containing protein 3Caspase 3--Pubmed
BINDbaculoviral IAP repeat-containing protein 3caspase 3 preproproteincIAP2 exhibits E3 ubiquitin ligase activity towards Casp3.-Pubmed
HPRDApoptosis inhibitor 3caspase 3 preproprotein--Pubmed
HPRDbaculoviral IAP repeat-containing protein 4Caspase 3--Pubmed
BINDbaculoviral IAP repeat-containing protein 4caspase 3 preproproteinCaspase-3 interacts with XIAP.-Pubmed
BINDbaculoviral IAP repeat-containing protein 4caspase 3 preproproteinXIAP interacts with Casp-3.-Pubmed

Recent Publications on CASP3:

Pubmed Logo
Late-gestation ventricular myocardial reduction in fetuses of hyperglycemic CD1 mice is associated with increased apoptosis.
BACKGROUND: Previous work in our laboratory showed reduced myocardium and...
24th October, 2009
Instituto de Farmacologia y Morfofisiologia, Facultad de Ciencias Birth Defects Res B Dev Reprod Toxicol. 2009 Oct;86(5):409-15.
DOI Direct Link
Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3.
Serpins are a superfamily of structurally conserved proteins. Inhibitory...
23rd October, 2009
UNESS, Universidad de Guanajuato, Privada de Arteaga S/N, 38900 FEBS Lett. 2009 Sep 3;583(17):2743-8. Epub 2009 Aug 7.
DOI Direct Link
Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis.
Delayed Fas-mediated apoptosis in T cells is associated with inflammatory...
21st October, 2009
Institute of Basic Medical Sciences, National Cheng Kung University, Mol Immunol. 2009 Oct;46(16):3328-35. Epub 2009 Aug 20.
DOI Direct Link
Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II.
Our previous studies found that insulin-like growth factor-I receptor...
17th October, 2009
Institute of Biochemistry and Biotechnology, Chung Shan Medical Chin J Physiol. 2009 Feb 28;52(1):31-7.
The role of Cdk5 in retinoic acid-induced apoptosis of cervical cancer cell line.
Cdk5 is a small serine/threonine protein kinase which belongs to Cdk...
17th October, 2009
Department of Life Sciences, National Chung Hsing University, Taichung Chin J Physiol. 2009 Feb 28;52(1):23-30.

View more research publications.

BioNews Results for CASP3

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BioPortfolio Logo
Polymorphisms in the CASPASE Genes and Survival in Patients With Early-Stage Non-Small-Cell Lung Cancer [Thora
Journal of Clinical Oncology:  Oct 31 2009 5:48PM Matching: casp3

Clinical Trials:

Clinical Trials Logo
Study of the Use of a Single Dose of Erythropoietin to Treat Acute Myocardial Ischemia

Patents:

Patents logo
US Patent No.Title
7606403 Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6943022 Inhibition of apoptosis by the expression of antisense RNA of caspase-3
6916917 Chimeric pro-caspases and methods of using same

View more patents.

CASP3 results (if any) from reagent suppliers

Google CSE Logo
CASP3 Antibody
Specific antibody for the gene product of CASP3, the protein Caspase-3. Validated for specificity by gene-silencing with siRNA followed by Western blot
...
http://www.piercenet.com/Products/Browse.cfm?fldID=4AD885E7-...

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Caspase-3 (CASP3) Antibody (Center)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CASP3 antibody (Center) (Cat.#AP7563c), which was peroxidase-conjugated to the
...
http://www.abgent.com/products/catalog_no/AP7563c_Caspase_3_...

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CASP3 antibody, CASP3 (caspase 3. apoptosis-related cysteine ...
Buy quality rabbit CASP3 antibody (interacts with human), anti-CASP3, CASP3 ( caspase 3. apoptosis-related cysteine peptidase) antibody, rabbit polyclonal ...
http://www.genwaybio.com/product_info.php?products_id=44327...

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CASP3 Mouse Anti-Human Caspase 3 Apoptosis-Related Cysteine ...
CASP3. Mouse Anti-Human Caspase 3 Apoptosis-Related Cysteine. Peptidase Clone C33 mAb. Gene ID: 836. Description: Mouse Anti-Human Caspase 3 Clone C33 ...
http://www.cellsciences.com/PDF/CMC431.pdf...

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Caspase 3 antibody, Caspase 3 [T46L] Antibody, Mouse Monoclonal ...
Mouse monoclonal [T46L] to Caspase 3; 12367; Casp3; A830040C14Rik; Apopain; CPP32; Caspase-3; Lice; Yama;; 12367; Casp3; A830040C14Rik; Apopain; CPP32; ...
http://www.genwaybio.com/product_info.php?products_id=192361...

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C8487 Anti-Caspase 3, Active antibody produced in rabbit IgG ...
microarray: suitable. Gene Information, human ... CASP3(836). rat ... Casp3( 25402). mouse ... Casp3(12367). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C848...

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Caspase 3 active antibody, Caspase 3 active Antibody, Rabbit ...
Rabbit polyclonal to active Caspase 3; 836; CASP3; 600636; P42574; CPP32; CPP32B ; SCA-1;; Caspase-3, CASP3_HUMAN. [ N/A NP_004337.2 P42574 ].
http://www.genwaybio.com/product_info.php?products_id=197059...

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