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MAD1L1


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Symbol:MAD1L1
Name(s):MAD1 mitotic arrest deficient-like 1 (yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:HsMAD1, MAD1, PIG9, TP53I9, TXBP181
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17998396 PRP4 is a spindle assembly checkpoint protein required for MAD1 localization to the kinetochores.
17674037 The MAD1 gene could be a candidate tumor suppressor gene, and the down-regulation of MAD1 expression may contribute to tumorigenesis in human stomach.
17577784 Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies.
14978040 NEK2A interacts with MAD1 during spindle checkpoint signaling
12366697 Mad1 gene transfer inhibits the proliferation of human melanoma cells
12876282 a regulatory mechanism for the mitotic checkpoint in which MAD1 is inhibited by p53.
12351790 Hec1 was required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores
15782113 Stable partial downregulation of the spindle checkpoint gene MAD1, which is observed in human cancer, leads to a functional inactivation of the spindle checkpoint resulting in gross aneuploidy
15235594 HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations
15645079 c-myc and mad1 can regulate the hTERT transcript in a different manner in hTERT positive cells, but not in normal cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDMAD2-like 1MAD1-like 1TXBP181 interacts with HsMAD2.-Pubmed
HPRDMAD2-like 1MAD1-like 1--Pubmed
HPRDMAD2-like 1MAD1-like 1--Pubmed
BINDMAD2-like 1MAD1-like 1MAD1L1 (Mad1) interacts with MAD2L1 (Mad2).-Pubmed
HPRDTAX binding protein 181transcriptional co-repressor Sin3A--Pubmed
HPRDMAD1-like 1SIN3A--Pubmed
HPRDMAD1-like 1Long form of Human Sin3B mRNA, complete cds--Pubmed
HPRDMAD1-like 1kinetochore associated 2--Pubmed
HPRDMAD1-like 1kinetochore associated 2--Pubmed

Recent Publications on MAD1L1:

Pubmed Logo
[Expression and mutation of myc antagonist genes Mad1, Mxi1 and Rox in leukemia cells]
OBJECTIVE: To investigate the expression and mutation of Mad1, Mxi1 and...
6th October, 2009
Department of Hematology, the Second Hospital of Hebei Medical University, Zhonghua Xue Ye Xue Za Zhi. 2007 Nov;28(11):745-9.
Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice.
Aneuploidy is defined as numerical abnormalities of chromosomes and is...
16th September, 2009
Department of Medicine, Hematology/Oncology Section, University of Carcinogenesis. 2009 Sep;30(9):1469-74. Epub 2009 Apr 16.
DOI Direct Link
Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5.
The products encoded by ski and its related gene, sno, (Ski and Sno) act...
11th April, 2009
Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Genes Cells. 2009 Jan;14(1):17-28. Epub 2008 Nov 21.
DOI Direct Link
In vivo dynamics of Drosophila nuclear envelope components.
Nuclear pore complexes (NPCs) are multisubunit protein entities embedded...
28th February, 2009
Institut Curie, Centre de Recherche, Paris Cedex 05, France. Mol Biol Cell. 2008 Sep;19(9):3652-66. Epub 2008 Jun 18.
DOI Direct Link
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.
The mitotic arrest-deficient protein Mad1 forms a complex with Mad2, which...
27th February, 2009
Helen Diller Family Comprehensive Cancer Center, University of California Genes Dev. 2008 Nov 1;22(21):2926-31.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7601532 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
7585634 Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof

MAD1L1 results (if any) from reagent suppliers

Google CSE Logo
MAD1 antibody [9B10] (ab5783) | Abcam
Mouse monoclonal [9B10] to MAD1. MAD1 is a non-essential gene that encodes a component of the spindle checkpoint. The spindle checkpoint delays the onset of
...
http://www.abcam.com/MAD1L1-antibody-9B10-ab5783.html...

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Nuclear Pore Complex Antibodies
Primary Description: Mouse Anti- Mad1L1. Alternative Description : hMAD1 ... Alternative Description : MAD1L1 Catalogue No: IQ200 Clone: 9B10 ...
http://www.immuquest.com/AntibodyCategoriesList.asp?CatID=7...

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MAD1 (H-228) Antibody sc-67338
Human, MAD1L1, 8379, 7p22.3, NM_001013836, NM_001013837, NM_003550 · Q9Y6D9 · 602686. Mouse, Mad1l1, 17120, 5 G2, Q9WTX8 ...
http://www.scbt.com/datasheet-67338-mad1-h-228-antibody.html...

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Antibodies to Cell Cycle Regulators
M8069, Monoclonal Anti-Mad1 antibody produced in mouse, 9B10 (monoclonal), purified immunoglobulin, human ... MAD1L1(8379), human, ARR, ICC, IP, pricing
...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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MAD1 (G-12) Antibody sc-166322
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, MAD1L1, 8379, 7p22.3, Q9Y6D9 ...
http://www.scbt.com/datasheet-166322-mad1-g-12-antibody.html...

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Anti-Telomerase catalytic subunit (hTERT) (Rabbit)
200-301-174 · Anti p53 (Mouse), 100ug, $245.00. 600-401-690 · Anti-E2F-1 pS364 ( Rabbit), 100ug, $245.00. 200-301-903 · Anti-Human MAD1L1, 100ug, $245.00 ...
http://www.rockland-inc.com/ccp9634-anti-telomerase-catalyti...

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June 07 NPR_No prices.indd
MAD1L1. Human. Goat IgG. AF4194. 100 µg. Matriptase/ST14. Human. Sheep IgG. AF3946. 100 µg. MBD-3. Human. Goat IgG. AF3839. 100 µg. MBL-1. Mouse. Goat IgG
...
http://www.rndsystems.com/DAM_public/5934.pdf...

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