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BCAR3

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Symbol:	BCAR3
Name(s):	breast cancer anti-estrogen resistance 3
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	KIAA0554, NSP2, SH2D3B
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
17427198	BCAR3 induces anti-estrogen resistance in breast tumor cell lines by altering cell-cell/cell-matrix interactions and cyclin D1 promoter activity.
15671247	AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner
17616674	the spatial and temporal regulation of BCAR3/p130(Cas) interactions within the cell is important for controlling breast cancer cell motility
17270363	BCAR3 and NSP1 are more highly expressed than SH2D3C (SHEP1) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	neural precursor cell expressed, developmentally down-regulated 9 isoform 1	breast cancer antiestrogen resistance 3	-	-	Pubmed

Recent Publications on BCAR3:
AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. NSP protein family members associate with p130Cas, a focal adhesion...	15th August, 2009	Department of Medicine, Section of Hematology and Oncology, Boston Medical	Cell Signal. 2009 Sep;21(9):1423-35. Epub 2009 May 18. DOI Direct Link
Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. PURPOSE: AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3)...	21st July, 2009	Department of Medicine, Boston Medical Center, Boston, MA 2118, USA.	Mol Vis. 2009;15:685-99. Epub 2009 Apr 3.
Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. Choline is an essential nutrient that serves as a donor of metabolic...	2nd May, 2009	Department of Pathology and Laboratory Medicine, Boston University School	FASEB J. 2009 Apr;23(4):1054-63. Epub 2008 Dec 1. DOI Direct Link
Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance. The association between novel Src homology 2-containing protein (NSP) and...	5th March, 2009	INSERM, U554, 34090 Montpellier, France.	J Mol Biol. 2009 Feb 13;386(1):190-203. Epub 2008 Dec 13. DOI Direct Link
Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. Calcium-regulated non-receptor proline-rich tyrosine kinase 2 (Pyk2) is a...	28th February, 2009	Division of Nephrology, Department of Medicine, Kidney Disease Center,	J Cell Physiol. 2009 Apr;219(1):45-56. DOI Direct Link
→View more research publications.

Patents:
US Patent No.	Title
7604939	Methods of identifying active BRM expression-promoting HDAC inhibitors
7598031	Method for the detection of gene transcripts in blood and uses thereof
7547687	Therapeutic treatment methods
7482334	Therapeutic treatment methods
7442390	Method for enhancing engraftment of cells using mesenchymal progenitor cells
→View more patents.

BCAR3 results (if any) from reagent suppliers

BCAR3 antibody (ab21705) \| Abcam Goat polyclonal to BCAR3. BCAR3 is a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer ... http://www.abcam.com/BCAR3-antibody-ab21705.html...
BCAR3 (N-15) Antibody sc-47811 BCAR3 shRNA (h) Lentiviral Particles, sc-60265-V, 200 µl ... BCAR3 (N-15): sc- 47811. Western blot analysis of BCAR3 expression in MCF7 whole cell lysate. ... http://www.scbt.com/datasheet-47811-bcar3-n-15-antibody.html...
The Abcam catalog BCAR3 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab21705 · BCAR3 antibody. Fast Track. Goat polyclonal ... http://www.abcam.com/index.html?t=8795&pt=1&c=612...
BCAR3 (h): 293T Lysate sc-115467 100 µg protein in 200 µl SDS-PAGE buffer; suitable as Western Blotting control for BCAR3 antibodies; human BCAR3 transfected 293T lysate; suitable control ... http://www.scbt.com/ko/datasheet-115467-bcar3-h-293t-lysate....
Abgent - Phosphorylation Antibodies - Phosphorylation AP7263d, BAR2 Antibody (S261), WB, IHC, E, H, M. AT1278a, BCAR3 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AP7090b, BCKDK Antibody (C-term T340) ... http://www.abgent.com/products/category/protein_modification...
BCAR3 siRNA (m) sc-60266 Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: BCAR3 (m)-PR: sc-60266-PR, 20 µl ... http://www.scbt.com/ko/datasheet-60266-bcar3-sirna-m.html...
FAK antibody, FAK (Ab-925) Antibody, Rabbit Polyclonal Antibody Subunit: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with SHB (By similarity). Interacts with TGFB1I1. ... http://www.genwaybio.com/product_info.php?products_id=210161...

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BCAR3

Gene Information from Publications

Interacting gene products

Recent Publications on BCAR3:

Patents:

BCAR3 results (if any) from reagent suppliers